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IID00017  Retinoblastoma-associated protein (Homo sapiens) P06400
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
928
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 52-355 Monomer :
 Evidence X-RAY 2qdj A Reference
       Region 2qdj A 52-83 order
       Region 2qdj A 84-93 disorder
       Region 2qdj A 94-206 order
       Region 2qdj A 207-209 disorder
       Region 2qdj A 210-244 order
       Region 2qdj A 245-269 disorder
       Region 2qdj A 270-303 order
       Region 2qdj A 304-310 disorder
       Region 2qdj A 311-355 order
Seq 53-787 Monomer :
 Evidence X-RAY 4elj A Reference
       Region 4elj A 53-88 order
       Region 4elj A 89-93 disorder
       Region 4elj A 94-176 order
       Region 4elj A 177-184 disorder
       Region 4elj A 185-267 order
       Region 4elj A 268-269 disorder
       Region 4elj A 270-345 order
       Region 4elj A 346-370 disorder
       Region 4elj A 371-503 order
       Region 4elj A 504-507 disorder
       Region 4elj A 508-579 order
       Region 4elj A 580-581 disorder
       Region 4elj A 582-640 order
       Region 4elj A 641-642 disorder
       Region 4elj A 643-771 order
       Region 4elj A 772-787 disorder
Seq 372-589,636-787 Hetero trimer :
 Evidence X-RAY 1gux A Reference
       Region 1gux A 372-379 disorder
       Region 1gux A 380-464 order
       Region 1gux A 465-471 disorder
       Region 1gux A 472-499 order
       Region 1gux A 500-513 disorder
       Region 1gux A 514-577 order
       Region 1gux A 578-589 disorder
 Evidence X-RAY 1gux B Reference
       Region 1gux B 636-644 disorder
       Region 1gux B 645-785 order
       Region 1gux B 786-787 disorder
Seq 372-589,636-787 Hetero trimer : IID00064Complex
 Evidence X-RAY 1o9k A Reference
       Region 1o9k A 372-378 disorder
       Region 1o9k A 379-501 order
       Region 1o9k A 502-507 disorder
       Region 1o9k A 508-578 order
       Region 1o9k A 579-589 disorder
 Evidence X-RAY 1o9k C Reference
       Region 1o9k C 372-378 disorder
       Region 1o9k C 379-501 order
       Region 1o9k C 502-507 disorder
       Region 1o9k C 508-578 order
       Region 1o9k C 579-589 disorder
 Evidence X-RAY 1o9k E Reference
       Region 1o9k E 372-378 disorder
       Region 1o9k E 379-501 order
       Region 1o9k E 502-507 disorder
       Region 1o9k E 508-578 order
       Region 1o9k E 579-589 disorder
 Evidence X-RAY 1o9k G Reference
       Region 1o9k G 372-378 disorder
       Region 1o9k G 379-501 order
       Region 1o9k G 502-507 disorder
       Region 1o9k G 508-578 order
       Region 1o9k G 579-589 disorder
 Evidence X-RAY 1o9k B Reference
       Region 1o9k B 636-643 disorder
       Region 1o9k B 644-787 order
 Evidence X-RAY 1o9k D Reference
       Region 1o9k D 636-643 disorder
       Region 1o9k D 644-787 order
 Evidence X-RAY 1o9k F Reference
       Region 1o9k F 636-643 disorder
       Region 1o9k F 644-787 order
 Evidence X-RAY 1o9k H Reference
       Region 1o9k H 636-643 disorder
       Region 1o9k H 644-787 order
Seq 378-562 Monomer :
 Evidence X-RAY 1ad6 A Reference
       Region 1ad6 A 378-562 order
Seq 379-577,645-772 Hetero trimer : IID90002Complex
 Evidence X-RAY 1gh6 B Reference
       Region 1gh6 B 379-502 order
       Region 1gh6 B 503-509 disorder
       Region 1gh6 B 510-577 order
       Region 1gh6 B 645-772 order
Seq 380-577,643-783 Hetero dimer :
 Evidence X-RAY 3pom B Reference
       Region 3pom B 380-381 disorder
       Region 3pom B 382-501 order
       Region 3pom B 502-509 disorder
       Region 3pom B 510-577 order
       Region 3pom B 643-643 disorder
       Region 3pom B 644-783 order
Seq 380-577,643-783 Hetero dimer :
 Evidence X-RAY 3pom A Reference
       Region 3pom A 380-382 disorder
       Region 3pom A 383-577 order
       Region 3pom A 643-783 order
Seq 380-785 Hetero dimer : IID00171Complex
 Evidence X-RAY 1n4m A Reference
       Region 1n4m A 380-785 order
Seq 380-785 Hetero trimer : IID00171Complex
 Evidence X-RAY 1n4m B Reference
       Region 1n4m B 380-502 order
       Region 1n4m B 503-509 disorder
       Region 1n4m B 510-785 order
Seq 380-787 Monomer :
 Evidence X-RAY 4ell A Reference
       Region 4ell A 380-382 disorder
       Region 4ell A 383-437 order
       Region 4ell A 438-439 disorder
       Region 4ell A 440-499 order
       Region 4ell A 500-511 disorder
       Region 4ell A 512-576 order
       Region 4ell A 577-599 disorder
       Region 4ell A 600-610 order
       Region 4ell A 611-643 disorder
       Region 4ell A 644-783 order
       Region 4ell A 784-787 disorder
 Evidence X-RAY 4ell B Reference
       Region 4ell B 380-383 disorder
       Region 4ell B 384-499 order
       Region 4ell B 500-510 disorder
       Region 4ell B 511-589 order
       Region 4ell B 590-599 disorder
       Region 4ell B 600-609 order
       Region 4ell B 610-642 disorder
       Region 4ell B 643-786 order
       Region 4ell B 787-787 disorder
Seq 380-581,643-787 Hetero pentamer : IID90003Complex
 Evidence X-RAY 2r7g A Reference
       Region 2r7g A 380-502 order
       Region 2r7g A 503-508 disorder
       Region 2r7g A 509-578 order
       Region 2r7g A 579-581 disorder
       Region 2r7g A 643-785 order
       Region 2r7g A 786-787 disorder
 Evidence X-RAY 2r7g C Reference
       Region 2r7g C 380-502 order
       Region 2r7g C 503-508 disorder
       Region 2r7g C 509-579 order
       Region 2r7g C 580-581 disorder
       Region 2r7g C 643-785 order
       Region 2r7g C 786-787 disorder
Seqdisorder 786-874
 Evidence NMR The disorder data is in the supplement of the reference. Reference
       Region 786-874 disorder
Seq 802-817 Hetero tetramer : IID00123Complex
 Evidence X-RAY 4cri C Reference
       Region 4cri C 802-803 disorder
       Region 4cri C 804-810 order
       Region 4cri C 811-817 disorder
 Evidence X-RAY 4cri D Reference
       Region 4cri D 802-804 disorder
       Region 4cri D 805-810 order
       Region 4cri D 811-817 disorder
Seq 829-874 Hetero trimer : IID00064Complex,IID00076Complex
 Evidence X-RAY 2aze C Reference
       Region 2aze C 829-872 order
       Region 2aze C 873-874 disorder
Seq 858-881 Hetero dimer : IID50009Complex
 Evidence X-RAY 1pjm A Reference
       Region 1pjm A 858-881 order
Seq 868-878 Hetero trimer : IID00032Complex
 Evidence X-RAY 1h25 E Reference
       Region 1h25 E 868-868 disorder
       Region 1h25 E 869-878 order
Seq 870-882 Hetero trimer : IID00311Complex
 Evidence X-RAY 3n5u C Reference
       Region 3n5u C 870-872 disorder
       Region 3n5u C 873-879 order
       Region 3n5u C 880-882 disorder
SeqProS verified 804-810 Hetero tetramer : IID00123Complex
       Region 4cri C 804-810 order
       Region 4cri D 805-810 order
       Region 786-874 disorder
SeqProS verified 829-872 Hetero trimer : IID00064Complex,IID00076Complex
       Region 2aze C 829-872 order
       Region 786-874 disorder
SeqProS possible 858-881 NLS Hetero dimer : IID50009Complex
       Region 1pjm A 858-881 order
       Region 786-874 disorder
SeqProS verified 869-878 Hetero trimer : IID00032Complex
       Region 1h25 E 869-878 order
       Region 786-874 disorder
SeqProS verified 873-879 Hetero trimer : IID00311Complex
       Region 3n5u C 873-879 order
       Region 786-874 disorder
Seqphosphorylation
    37-37 Phosphoserine
    249-249 Phosphoserine; by CDK1
    252-252 Phosphothreonine; by CDK1
    356-356 Phosphothreonine
    373-373 Phosphothreonine; by CDK1
    567-567 Phosphoserine; by CDK2
    608-608 Phosphoserine
    612-612 Phosphoserine; by CHEK2 and CHEK1
    624-624 Phosphoserine
    780-780 Phosphoserine
    788-788 Phosphoserine
    795-795 Phosphoserine
    807-807 Phosphoserine; by CDK1 and CDK3
    811-811 Phosphoserine; by CDK1 and CDK3
    821-821 Phosphothreonine; by CDK6
    823-823 Phosphothreonine
    826-826 Phosphothreonine; by CDK4
    841-841 Phosphothreonine
    855-855 Phosphoserine
Seqacetylation
    873-873 N6-acetyllysine; by PCAF
    874-874 N6-acetyllysine; by PCAF
 
Prediction
DICHOT
Disorder 1-52,581-642,786-928
Known Domain 53-580,643-785
SCOPe RPS-Blast
     1guxA 380-577 4e-61 a.74.1.3 Retinoblastoma tumor suppressor domains
     1guxB 645-785 1e-49 a.74.1.3 Retinoblastoma tumor suppressor domains
SCOP Hmmer
     1aisB1 59-138 6.4e-06 a.74.1.2 Transcription fa...
     1guxA_ 380-576 3.5e-78 a.74.1.3 Retinoblastoma ...
     1guxB_ 645-784 2.8e-61 a.74.1.3 Retinoblastoma ...
Pfam RPS-Blast
     PF11934 111-228 5e-22 Domain of unknown function ...
     PF01858 373-573 2e-57 Retinoblastoma-associated p...
     PF01857 647-764 5e-35 Retinoblastoma-associated p...
     PF08934 776-880 8e-17 Rb C-terminal domain
Pfam Hmmer
    PF11934 114-226 4e-15 Domain of unknown function (...
    PF01858 373-573 2.8e-79 Retinoblastoma-associated ...
    PF01857 646-765 1.1e-37 Retinoblastoma-associated ...
    PF08934 768-925 1.4e-86 Rb C-terminal domain