Search Keyword:


Search option:


IID00035  Adenomatous polyposis coli protein (Homo sapiens) P25054
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
2843
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-55 Monomer :
 Evidence X-RAY 1deb A Reference
       Region 1deb A 2-55 order
 Evidence X-RAY 1deb B Reference
       Region 1deb B 2-2 disorder
       Region 1deb B 3-55 order
Seq 126-250 Monomer :
 Evidence X-RAY 1m5i A Reference
       Region 1m5i A 126-129 disorder
       Region 1m5i A 130-173 order
       Region 1m5i A 174-178 disorder
       Region 1m5i A 179-239 order
       Region 1m5i A 240-250 disorder
Seq 303-739 Hetero dimer : IID00606Complex
 Evidence X-RAY 3nmz A Reference
       Region 3nmz A 303-325 disorder
       Region 3nmz A 326-369 order
       Region 3nmz A 370-372 disorder
       Region 3nmz A 373-437 order
       Region 3nmz A 438-439 disorder
       Region 3nmz A 440-736 order
       Region 3nmz A 737-739 disorder
 Evidence X-RAY 3nmz B Reference
       Region 3nmz B 303-325 disorder
       Region 3nmz B 326-365 order
       Region 3nmz B 366-371 disorder
       Region 3nmz B 372-437 order
       Region 3nmz B 438-439 disorder
       Region 3nmz B 440-733 order
       Region 3nmz B 734-739 disorder
Seq 396-732 Hetero dimer : IID00619Complex
 Evidence X-RAY 3qhe A Reference
       Region 3qhe A 396-400 disorder
       Region 3qhe A 401-427 order
       Region 3qhe A 428-435 disorder
       Region 3qhe A 436-731 order
       Region 3qhe A 732-732 disorder
 Evidence X-RAY 3qhe C Reference
       Region 3qhe C 396-401 disorder
       Region 3qhe C 402-429 order
       Region 3qhe C 430-436 disorder
       Region 3qhe C 437-689 order
       Region 3qhe C 690-693 disorder
       Region 3qhe C 694-699 order
       Region 3qhe C 700-700 disorder
       Region 3qhe C 701-731 order
       Region 3qhe C 732-732 disorder
Seq 396-775 Monomer :
 Evidence X-RAY 3au3 A Reference
       Region 3au3 A 396-396 disorder
       Region 3au3 A 397-689 order
       Region 3au3 A 690-699 disorder
       Region 3au3 A 700-707 order
       Region 3au3 A 708-732 disorder
 Evidence X-RAY 5b6g A Reference
       Region 5b6g A 407-427 order
       Region 5b6g A 428-435 disorder
       Region 5b6g A 436-741 order
       Region 5b6g A 742-751 disorder
 Evidence X-RAY 5iz6 A Reference
       Region 5iz6 A 407-427 order
       Region 5iz6 A 428-435 disorder
       Region 5iz6 A 436-741 order
       Region 5iz6 A 742-751 disorder
 Evidence X-RAY 5iz8 A Reference
       Region 5iz8 A 407-743 order
       Region 5iz8 A 744-751 disorder
 Evidence X-RAY 5iz8 B Reference
       Region 5iz8 B 407-701 order
       Region 5iz8 B 702-704 disorder
       Region 5iz8 B 705-724 order
       Region 5iz8 B 725-751 disorder
 Evidence X-RAY 5iz9 A Reference
       Region 5iz9 A 407-430 order
       Region 5iz9 A 431-435 disorder
       Region 5iz9 A 436-738 order
       Region 5iz9 A 739-751 disorder
 Evidence X-RAY 5iza A Reference
       Region 5iza A 407-743 order
       Region 5iza A 744-751 disorder
 Evidence X-RAY 3nmw A Reference
       Region 3nmw A 407-428 order
       Region 3nmw A 429-433 disorder
       Region 3nmw A 434-738 order
       Region 3nmw A 739-751 disorder
 Evidence X-RAY 3nmw B Reference
       Region 3nmw B 407-428 order
       Region 3nmw B 429-433 disorder
       Region 3nmw B 434-738 order
       Region 3nmw B 739-751 disorder
 Evidence X-RAY 3t7u A Reference
       Region 3t7u A 407-424 order
       Region 3t7u A 425-437 disorder
       Region 3t7u A 438-487 order
       Region 3t7u A 488-491 disorder
       Region 3t7u A 492-624 order
       Region 3t7u A 625-628 disorder
       Region 3t7u A 629-734 order
       Region 3t7u A 735-775 disorder
 Evidence X-RAY 3t7u B Reference
       Region 3t7u B 407-424 order
       Region 3t7u B 425-437 disorder
       Region 3t7u B 438-488 order
       Region 3t7u B 489-490 disorder
       Region 3t7u B 491-624 order
       Region 3t7u B 625-628 disorder
       Region 3t7u B 629-734 order
       Region 3t7u B 735-775 disorder
Seq 407-751 Hetero dimer : Q5JTC6
 Evidence X-RAY 4yk6 A Reference
       Region 4yk6 A 407-741 order
       Region 4yk6 A 742-751 disorder
Seq 407-751 Hetero dimer : Q5JTC6
 Evidence X-RAY 4yje A Reference
       Region 4yje A 407-738 order
       Region 4yje A 739-751 disorder
Seq 407-751 Hetero dimer : Q5JTC6
 Evidence X-RAY 4yjl A Reference
       Region 4yjl A 407-736 order
       Region 4yjl A 737-751 disorder
 Evidence X-RAY 4yjl B Reference
       Region 4yjl B 407-737 order
       Region 4yjl B 738-751 disorder
 Evidence X-RAY 4yjl C Reference
       Region 4yjl C 407-737 order
       Region 4yjl C 738-751 disorder
 Evidence X-RAY 4yjl D Reference
       Region 4yjl D 407-738 order
       Region 4yjl D 739-751 disorder
 Evidence X-RAY 4yjl E Reference
       Region 4yjl E 407-738 order
       Region 4yjl E 739-751 disorder
 Evidence X-RAY 4yjl F Reference
       Region 4yjl F 407-738 order
       Region 4yjl F 739-751 disorder
Seq 407-751 Hetero dimer : IID00606Complex
 Evidence X-RAY 3nmx A Reference
       Region 3nmx A 407-427 order
       Region 3nmx A 428-435 disorder
       Region 3nmx A 436-736 order
       Region 3nmx A 737-751 disorder
 Evidence X-RAY 3nmx B Reference
       Region 3nmx B 407-426 order
       Region 3nmx B 427-436 disorder
       Region 3nmx B 437-737 order
       Region 3nmx B 738-751 disorder
 Evidence X-RAY 3nmx C Reference
       Region 3nmx C 407-427 order
       Region 3nmx C 428-439 disorder
       Region 3nmx C 440-737 order
       Region 3nmx C 738-751 disorder
Seqdisorder 1021-1035
 Evidence CD Reference
       Region 1021-1035 disorder
Seq 1021-1035 Hetero dimer : IID50011Complex
 Evidence X-RAY 1jpp C Reference
       Region 1jpp C 1021-1031 order
       Region 1jpp C 1032-1035 disorder
 Evidence X-RAY 1jpp D Reference
       Region 1jpp D 1021-1034 order
       Region 1jpp D 1035-1035 disorder
Seq 1362-1540 Hetero dimer : IID00039Complex
 Evidence X-RAY 1th1 C Reference
       Region 1th1 C 1362-1467 disorder
       Region 1th1 C 1468-1496 order
       Region 1th1 C 1497-1502 disorder
       Region 1th1 C 1503-1529 order
       Region 1th1 C 1530-1540 disorder
 Evidence X-RAY 1th1 D Reference
       Region 1th1 D 1362-1468 disorder
       Region 1th1 D 1469-1496 order
       Region 1th1 D 1497-1503 disorder
       Region 1th1 D 1504-1529 order
       Region 1th1 D 1530-1540 disorder
Seqdisorder 1362-1745
 Evidence CD¸ NMR Reference
       Region 1362-1745 disorder
Seq 1482-1528 Hetero dimer : IID50011Complex
 Evidence X-RAY 1v18 B Reference
       Region 1v18 B 1482-1484 disorder
       Region 1v18 B 1485-1499 order
       Region 1v18 B 1500-1503 disorder
       Region 1v18 B 1504-1528 order
Seq 1484-1528 Hetero trimer : IID00039Complex
 Evidence X-RAY 1t08 C Reference
       Region 1t08 C 1484-1498 order
       Region 1t08 C 1499-1528 disorder
Seq 1578-1596 Hetero dimer : IID00333Complex
 Evidence NMR 2rqu B Reference
       Region 2rqu B 1578-1596 order
       Region 2rqu B 1594-1596 high_rmsd
Seq 2034-2059 Hetero dimer : IID00007Complex
 Evidence X-RAY 1emu B Reference
       Region 1emu B 2034-2049 order
       Region 1emu B 2050-2059 disorder
Seq 2833-2843 Hetero hexamer : IID00513Complex
 Evidence X-RAY 3rl8 F Reference
       Region 3rl8 F 2833-2837 disorder
       Region 3rl8 F 2838-2843 order
Seq 2833-2843 Hetero dimer : IID00513Complex
 Evidence X-RAY 4g69 B Reference
       Region 4g69 B 2833-2837 disorder
       Region 4g69 B 2838-2843 order
Seq 2833-2843 Hetero dimer : IID00513Complex
 Evidence X-RAY 3rl7 G Reference
       Region 3rl7 G 2833-2836 disorder
       Region 3rl7 G 2837-2843 order
 Evidence X-RAY 3rl7 H Reference
       Region 3rl7 H 2833-2837 disorder
       Region 3rl7 H 2838-2842 order
       Region 3rl7 H 2843-2843 disorder
 Evidence X-RAY 3rl7 J Reference
       Region 3rl7 J 2833-2837 disorder
       Region 3rl7 J 2838-2843 order
 Evidence X-RAY 3rl7 I Reference
       Region 3rl7 I 2833-2837 disorder
       Region 3rl7 I 2838-2842 order
       Region 3rl7 I 2843-2843 disorder
 Evidence X-RAY 3rl7 K Reference
       Region 3rl7 K 2833-2838 disorder
       Region 3rl7 K 2839-2843 order
 Evidence X-RAY 3rl7 L Reference
       Region 3rl7 L 2833-2838 disorder
       Region 3rl7 L 2839-2842 order
       Region 3rl7 L 2843-2843 disorder
SeqProS verified 1021-1034 Hetero dimer : IID50011Complex
       Region 1jpp D 1021-1034 order
       Region 1jpp C 1021-1031 order
       Region 1021-1035 disorder
SeqProS verified 1468-1496,1503-1529 This region is ordered in the phosphorylated form, but disordered in the unphosphorylated form. Hetero dimer : IID00039Complex
       Region 1th1 C 1468-1496 order
       Region 1th1 D 1469-1496 order
       Region 1th1 C 1503-1529 order
       Region 1th1 D 1504-1529 order
       Region 1362-1745 disorder
SeqProS verified 1484-1498 Hetero trimer : IID00039Complex
       Region 1t08 C 1484-1498 order
       Region 1362-1745 disorder
SeqProS verified 1485-1499,1504-1528 This region is ordered in the phosphorylated form, but disordered in the unphosphorylated form. Hetero dimer : IID50011Complex
       Region 1v18 B 1485-1499 order
       Region 1v18 B 1504-1528 order
       Region 1362-1745 disorder
SeqProS verified 1578-1596 Hetero dimer : IID00333Complex
       Region 2rqu B 1578-1596 order
       Region 1362-1745 disorder
SeqProS possible 2034-2049 APC has three Axin binding repeats, SAMP1, SAMP2, and SAMP3. Because SAMP1 (1578-1596) is shown to be a verified ProS, this region, SAMP3, is possibly also ProS. Hetero dimer : IID00007Complex
       Region 1emu B 2034-2049 order
SeqProS possible 2837-2843 This region is described to be disordered in free state (PubMed=15958564, 21859464). Hetero dimer : IID00513Complex
       Region 3rl7 G 2837-2843 order
       Region 3rl7 H 2838-2842 order
       Region 3rl7 I 2838-2842 order
       Region 3rl7 J 2838-2843 order
       Region 3rl7 K 2839-2843 order
       Region 3rl7 L 2839-2842 order
SeqProS possible 2838-2843 This region is described to be disordered in free state (PubMed=15958564, 21859464). Hetero hexamer : IID00513Complex
       Region 3rl8 F 2838-2843 order
SeqProS possible 2838-2843 This region is described to be disordered in free state (PubMed=15958564, 21859464). Hetero dimer : IID00513Complex
       Region 4g69 B 2838-2843 order
Seqphosphorylation
    107-107 Phosphoserine
    111-111 Phosphoserine
    744-744 Phosphoserine
    748-748 Phosphoserine
    780-780 Phosphoserine
    908-908 Phosphoserine
    987-987 Phosphoserine
    1038-1038 Phosphoserine
    1042-1042 Phosphoserine
    1360-1360 Phosphoserine
    1371-1371 Phosphoserine
    1385-1385 Phosphoserine
    1392-1392 Phosphoserine
    1395-1395 Phosphoserine
    1438-1438 Phosphothreonine
    1567-1567 Phosphoserine
    1774-1774 Phosphoserine
    1861-1861 Phosphoserine
    1863-1863 Phosphoserine
    1864-1864 Phosphoserine
    1971-1971 Phosphoserine
    1973-1973 Phosphoserine
    2088-2088 Phosphoserine
    2093-2093 Phosphoserine
    2125-2125 Phosphoserine
    2129-2129 Phosphoserine
    2130-2130 Phosphoserine
    2132-2132 Phosphoserine
    2151-2151 Phosphothreonine
    2260-2260 Phosphoserine
    2270-2270 Phosphoserine
    2283-2283 Phosphoserine
    2473-2473 Phosphoserine
    2535-2535 Phosphoserine
    2569-2569 Phosphoserine
    2671-2671 Phosphoserine
    2674-2674 Phosphoserine
    2679-2679 Phosphothreonine
    2710-2710 Phosphoserine
    2724-2724 Phosphoserine
    2789-2789 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
DICHOT
Disorder 1-2,55-156,240-406,739-2843
Known Domain 3-54,157-239,407-738
SCOPe RPS-Blast
     4r10A 297-732 6e-47 a.118.1.0 automated matches
SCOP Hmmer
     1debA_ 3-54 2.5e-24 h.1.18.1 N-terminal coiled ...
     1m5iA_ 130-239 1.1e-46 h.4.13.1 Tumor suppresso...
     1g3jA_ 350-745 2.1e-44 a.118.1.1 beta-Catenin
Pfam RPS-Blast
     PF16689 4-55 9e-15 Coiled-coil N-terminus of APC,...
     PF11414 136-207 6e-11 Adenomatous polyposis coli ...
     PF18797 393-466 1e-23 Adenomatous polyposis coli ...
     PF05804 442-736 6e-10 Kinesin-associated protein ...
     PF16629 733-1007 4e-75 Armadillo-associated regio...
     PF16630 1036-1135 9e-39 Unstructured region on AP...
     PF16633 1283-1368 7e-28 Unstructured region on AP...
     PF16634 1662-1715 1e-16 Unstructured region on AP...
     PF16635 1746-1839 8e-32 Unstructured region on AP...
     PF16636 1867-1947 8e-21 Unstructured region on AP...
     PF05956 2224-2473 5e-33 APC basic domain
     PF05937 2670-2828 5e-51 EB-1 Binding Domain
Pfam Hmmer
    PF16689 4-55 1.5e-31 Coiled-coil N-terminus of APC...
    PF11414 131-206 1.3e-23 Adenomatous polyposis coli...
    PF18797 393-466 1.7e-40 Adenomatous polyposis coli...
    PF00514 515-552 1e-07 Armadillo/beta-catenin-like ...
    PF00514 649-689 1.1e-10 Armadillo/beta-catenin-lik...
    PF16629 732-1019 2.4e-172 Armadillo-associated reg...
    PF05972 1020-1034 5.7e-08 APC 15 residue motif
    PF16630 1036-1135 2.5e-56 Unstructured region on A...
    PF05972 1155-1169 8.1e-08 APC 15 residue motif
    PF05972 1172-1186 9.4e-09 APC 15 residue motif
    PF05923 1259-1280 1.4e-14 APC repeat
    PF16633 1282-1368 9.9e-39 Unstructured region on A...
    PF05923 1372-1393 8.2e-10 APC repeat
    PF05923 1486-1509 9.1e-09 APC repeat
    PF05924 1567-1588 8.2e-12 SAMP Motif
    PF05923 1637-1660 2.4e-14 APC repeat
    PF16634 1662-1715 7.3e-29 Unstructured region on A...
    PF05924 1718-1737 5.3e-11 SAMP Motif
    PF16635 1746-1839 6.7e-45 Unstructured region on A...
    PF05923 1841-1865 6.9e-14 APC repeat
    PF16636 1867-1947 4.2e-41 Unstructured region on A...
    PF05923 1950-1972 1.9e-12 APC repeat
    PF05923 2008-2030 1.7e-13 APC repeat
    PF05924 2031-2051 3.6e-13 SAMP Motif
    PF05956 2224-2575 3.8e-116 APC basic domain
    PF05937 2670-2843 5.8e-98 EB-1 Binding Domain