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IID00042  Breast cancer type 1 susceptibility protein (Homo sapiens) P38398
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
1863
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-110 Hetero dimer : Q99728
 Evidence NMR 1jm7 A Reference
       Region 1jm7 A 1-103 order
       Region 1jm7 A 103-103 high_rmsd
       Region 1jm7 A 104-110 disorder
Seqdisorder 100-1649
 Evidence NMR¸CD Reference
       Region 100-219 disorder
       Region 170-360 disorder
       Region 219-408 disorder
       Region 219-758 disorder
       Region 219-498 disorder
       Region 360-498 disorder
       Region 360-758 disorder
       Region 408-540 disorder
       Region 444-1057 disorder
       Region 498-663 disorder
       Region 540-758 disorder
       Region 663-894 disorder
       Region 758-936 disorder
       Region 758-1057 disorder
       Region 894-1057 disorder
       Region 936-1113 disorder
       Region 1057-1234 disorder
       Region 1113-1316 disorder
       Region 1234-1443 disorder
       Region 1316-1538 disorder
       Region 1443-1649 disorder
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 1t2v E Reference
       Region 1t2v E 1646-1648 disorder
       Region 1t2v E 1649-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 1t2v C Reference
       Region 1t2v C 1646-1648 disorder
       Region 1t2v C 1649-1799 order
       Region 1t2v C 1800-1804 disorder
       Region 1t2v C 1805-1816 order
       Region 1t2v C 1817-1820 disorder
       Region 1t2v C 1821-1859 order
Seq 1646-1859 Hetero dimer : IID00611Complex
 Evidence X-RAY 4ifi A Reference
       Region 4ifi A 1646-1648 disorder
       Region 4ifi A 1649-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 3pxe A Reference
       Region 3pxe A 1646-1646 disorder
       Region 3pxe A 1647-1801 order
       Region 3pxe A 1802-1803 disorder
       Region 3pxe A 1804-1859 order
Seq 1646-1859 Hetero dimer : IID00181Complex
 Evidence X-RAY 1t15 A Reference
       Region 1t15 A 1646-1648 disorder
       Region 1t15 A 1649-1859 order
 Evidence X-RAY 1t29 A Reference
       Region 1t29 A 1646-1648 disorder
       Region 1t29 A 1649-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 1t2v A Reference
       Region 1t2v A 1646-1648 disorder
       Region 1t2v A 1649-1799 order
       Region 1t2v A 1800-1802 disorder
       Region 1t2v A 1803-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 1t2v B Reference
       Region 1t2v B 1646-1816 order
       Region 1t2v B 1817-1820 disorder
       Region 1t2v B 1821-1859 order
Seq 1646-1859 Hetero dimer : Q8WXE1
 Evidence X-RAY 4igk A Reference
       Region 4igk A 1646-1815 order
       Region 4igk A 1816-1818 disorder
       Region 4igk A 1819-1859 order
 Evidence X-RAY 4igk B Reference
       Region 4igk B 1646-1815 order
       Region 4igk B 1816-1818 disorder
       Region 4igk B 1819-1859 order
Seq 1646-1859 Hetero dimer : IID00610Complex
 Evidence X-RAY 3coj X Reference
       Region 3coj X 1646-1647 disorder
       Region 3coj X 1648-1693 order
       Region 3coj X 1694-1694 disorder
       Region 3coj X 1695-1816 order
       Region 3coj X 1817-1819 disorder
       Region 3coj X 1820-1859 order
 Evidence X-RAY 3coj A Reference
       Region 3coj A 1646-1647 disorder
       Region 3coj A 1648-1693 order
       Region 3coj A 1694-1694 disorder
       Region 3coj A 1695-1816 order
       Region 3coj A 1817-1819 disorder
       Region 3coj A 1820-1859 order
 Evidence X-RAY 3coj B Reference
       Region 3coj B 1646-1647 disorder
       Region 3coj B 1648-1693 order
       Region 3coj B 1694-1694 disorder
       Region 3coj B 1695-1816 order
       Region 3coj B 1817-1819 disorder
       Region 3coj B 1820-1859 order
 Evidence X-RAY 3coj C Reference
       Region 3coj C 1646-1647 disorder
       Region 3coj C 1648-1693 order
       Region 3coj C 1694-1694 disorder
       Region 3coj C 1695-1816 order
       Region 3coj C 1817-1819 disorder
       Region 3coj C 1820-1859 order
 Evidence X-RAY 3coj D Reference
       Region 3coj D 1646-1648 disorder
       Region 3coj D 1649-1693 order
       Region 3coj D 1694-1694 disorder
       Region 3coj D 1695-1816 order
       Region 3coj D 1817-1819 disorder
       Region 3coj D 1820-1859 order
 Evidence X-RAY 3coj E Reference
       Region 3coj E 1646-1648 disorder
       Region 3coj E 1649-1693 order
       Region 3coj E 1694-1694 disorder
       Region 3coj E 1695-1816 order
       Region 3coj E 1817-1819 disorder
       Region 3coj E 1820-1859 order
 Evidence X-RAY 3coj F Reference
       Region 3coj F 1646-1648 disorder
       Region 3coj F 1649-1693 order
       Region 3coj F 1694-1694 disorder
       Region 3coj F 1695-1816 order
       Region 3coj F 1817-1819 disorder
       Region 3coj F 1820-1859 order
 Evidence X-RAY 3coj G Reference
       Region 3coj G 1646-1647 disorder
       Region 3coj G 1648-1693 order
       Region 3coj G 1694-1694 disorder
       Region 3coj G 1695-1814 order
       Region 3coj G 1815-1819 disorder
       Region 3coj G 1820-1859 order
Seq 1646-1859 Monomer :
 Evidence X-RAY 2ing X Reference
       Region 2ing X 1649-1693 order
       Region 2ing X 1694-1694 disorder
       Region 2ing X 1695-1816 order
       Region 2ing X 1817-1818 disorder
       Region 2ing X 1819-1859 order
 Evidence X-RAY 1jnx X Reference
       Region 1jnx X 1646-1648 disorder
       Region 1jnx X 1649-1693 order
       Region 1jnx X 1694-1694 disorder
       Region 1jnx X 1695-1816 order
       Region 1jnx X 1817-1819 disorder
       Region 1jnx X 1820-1859 order
 Evidence X-RAY 3k0h A Reference
       Region 3k0h A 1646-1648 disorder
       Region 3k0h A 1649-1859 order
 Evidence X-RAY 3k0k A Reference
       Region 3k0k A 1646-1648 disorder
       Region 3k0k A 1649-1859 order
 Evidence X-RAY 3k15 A Reference
       Region 3k15 A 1646-1648 disorder
       Region 3k15 A 1649-1859 order
 Evidence X-RAY 3k16 A Reference
       Region 3k16 A 1646-1648 disorder
       Region 3k16 A 1649-1859 order
 Evidence X-RAY 1n5o X Reference
       Region 1n5o X 1646-1648 disorder
       Region 1n5o X 1649-1693 order
       Region 1n5o X 1694-1694 disorder
       Region 1n5o X 1695-1816 order
       Region 1n5o X 1817-1819 disorder
       Region 1n5o X 1820-1859 order
 Evidence X-RAY 4ofb A Reference
       Region 4ofb A 1646-1648 disorder
       Region 4ofb A 1649-1816 order
       Region 4ofb A 1817-1818 disorder
       Region 4ofb A 1819-1859 order
 Evidence X-RAY 3pxa A Reference
       Region 3pxa A 1646-1648 disorder
       Region 3pxa A 1649-1816 order
       Region 3pxa A 1817-1820 disorder
       Region 3pxa A 1821-1859 order
 Evidence X-RAY 3pxb A Reference
       Region 3pxb A 1646-1648 disorder
       Region 3pxb A 1649-1816 order
       Region 3pxb A 1817-1819 disorder
       Region 3pxb A 1820-1859 order
 Evidence X-RAY 3pxc X Reference
       Region 3pxc X 1646-1648 disorder
       Region 3pxc X 1649-1693 order
       Region 3pxc X 1694-1694 disorder
       Region 3pxc X 1695-1816 order
       Region 3pxc X 1817-1820 disorder
       Region 3pxc X 1821-1859 order
 Evidence X-RAY 3pxd A Reference
       Region 3pxd A 1646-1648 disorder
       Region 3pxd A 1649-1816 order
       Region 3pxd A 1817-1818 disorder
       Region 3pxd A 1819-1859 order
 Evidence X-RAY 1t2u A Reference
       Region 1t2u A 1646-1648 disorder
       Region 1t2u A 1649-1816 order
       Region 1t2u A 1817-1820 disorder
       Region 1t2u A 1821-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 1y98 A Reference
       Region 1y98 A 1646-1648 disorder
       Region 1y98 A 1649-1859 order
Seq 1646-1859 Hetero dimer : Q6UWZ7
 Evidence X-RAY 4jlu A Reference
       Region 4jlu A 1649-1859 order
 Evidence X-RAY 4u4a A Reference
       Region 4u4a A 1646-1859 order
 Evidence X-RAY 4u4a B Reference
       Region 4u4a B 1646-1859 order
 Evidence X-RAY 4u4a C Reference
       Region 4u4a C 1646-1647 disorder
       Region 4u4a C 1648-1859 order
 Evidence X-RAY 4y18 A Reference
       Region 4y18 A 1646-1859 order
 Evidence X-RAY 4y18 G Reference
       Region 4y18 G 1646-1648 disorder
       Region 4y18 G 1649-1859 order
 Evidence X-RAY 4y18 H Reference
       Region 4y18 H 1646-1648 disorder
       Region 4y18 H 1649-1859 order
 Evidence X-RAY 4y18 B Reference
       Region 4y18 B 1646-1859 order
 Evidence X-RAY 4y18 C Reference
       Region 4y18 C 1646-1859 order
 Evidence X-RAY 4y18 D Reference
       Region 4y18 D 1646-1858 order
       Region 4y18 D 1859-1859 disorder
 Evidence X-RAY 4y18 E Reference
       Region 4y18 E 1646-1859 order
 Evidence X-RAY 4y18 F Reference
       Region 4y18 F 1646-1859 order
 Evidence X-RAY 4y2g A Reference
       Region 4y2g A 1646-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 1t2v D Reference
       Region 1t2v D 1646-1646 disorder
       Region 1t2v D 1647-1816 order
       Region 1t2v D 1817-1820 disorder
       Region 1t2v D 1821-1828 order
       Region 1t2v D 1829-1829 disorder
       Region 1t2v D 1830-1856 order
       Region 1t2v D 1857-1859 disorder
Seq 1646-1859 Hetero tetramer : Q6UWZ7
 Evidence X-RAY 4y18 G Reference
       Region 4y18 G 1646-1648 disorder
       Region 4y18 G 1649-1859 order
 Evidence X-RAY 4y18 H Reference
       Region 4y18 H 1646-1648 disorder
       Region 4y18 H 1649-1859 order
 Evidence X-RAY 4y18 A Reference
       Region 4y18 A 1646-1859 order
 Evidence X-RAY 4y18 B Reference
       Region 4y18 B 1646-1859 order
 Evidence X-RAY 4y18 C Reference
       Region 4y18 C 1646-1859 order
 Evidence X-RAY 4y18 E Reference
       Region 4y18 E 1646-1859 order
 Evidence X-RAY 4y18 D Reference
       Region 4y18 D 1646-1858 order
       Region 4y18 D 1859-1859 disorder
 Evidence X-RAY 4y18 F Reference
       Region 4y18 F 1646-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 3pxe D Reference
       Region 3pxe D 1646-1648 disorder
       Region 3pxe D 1649-1797 order
       Region 3pxe D 1798-1802 disorder
       Region 3pxe D 1803-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 3pxe C Reference
       Region 3pxe C 1646-1646 disorder
       Region 3pxe C 1647-1802 order
       Region 3pxe C 1803-1804 disorder
       Region 3pxe C 1805-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 3pxe B Reference
       Region 3pxe B 1646-1646 disorder
       Region 3pxe B 1647-1859 order
Seq 1755-1863 Monomer :
 Evidence NMR 1oqa A Reference
       Region 1oqa A 1755-1863 order
       Region 1oqa A 1755-1756 high_rmsd
       Region 1oqa A 1856-1863 high_rmsd
Seqphosphorylation
    114-114 Phosphoserine
    308-308 Phosphoserine; by AURKA
    395-395 Phosphoserine
    398-398 Phosphoserine
    423-423 Phosphoserine
    434-434 Phosphoserine
    551-551 Phosphoserine
    694-694 Phosphoserine
    708-708 Phosphoserine
    725-725 Phosphoserine
    753-753 Phosphoserine
    840-840 Phosphoserine
    988-988 Phosphoserine; by CHEK2
    1009-1009 Phosphoserine
    1143-1143 Phosphoserine; by ATR; in vitro
    1189-1189 Phosphoserine
    1191-1191 Phosphoserine
    1211-1211 Phosphoserine
    1217-1217 Phosphoserine
    1218-1218 Phosphoserine
    1280-1280 Phosphoserine; by ATR; in vitro
    1328-1328 Phosphoserine
    1336-1336 Phosphoserine
    1342-1342 Phosphoserine
    1387-1387 Phosphoserine; by ATM and ATR
    1394-1394 Phosphothreonine; by ATR; in vitro
    1423-1423 Phosphoserine; by ATM and ATR
    1457-1457 Phosphoserine; by ATR; in vitro
    1524-1524 Phosphoserine; by ATM
    1542-1542 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
DICHOT
Disorder 104-348,476-800,840-920,983-1648,1860-1863
Known Domain 1-103,349-475,1649-1859
Cryptic Domain 801-839,921-982
SCOPe RPS-Blast
     1jm7A 1-103 1e-40 g.44.1.1 Acute promyelocytic leukaemia proto-oncop...
     1t15A1 1649-1757 4e-36 c.15.1.3 Breast cancer associated protein, BR...
     1t15A2 1758-1859 3e-38 c.15.1.3 Breast cancer associated protein, BR...
SCOP Hmmer
     1jm7A_ 1-102 1.3e-40 g.44.1.1 Acute promyelocyt...
     1kzyC1 1608-1753 3.6e-30 c.15.1.4 53BP1
     1jnxX2 1759-1857 2.4e-25 c.15.1.3 Breast cancer...
Pfam RPS-Blast
     PF13923 23-64 7e-12 Zinc finger, C3HC4 type (RING...
     PF12820 345-507 4e-59 Serine-rich domain associat...
     PF16770 1641-1734 4e-08 Regulator of Ty1 transpos...
Pfam Hmmer
    PF00097 24-64 2e-12 Zinc finger, C3HC4 type (RING ...
    PF12820 345-507 3.1e-85 Serine-rich domain associa...
    PF00533 1660-1723 5.2e-10 BRCA1 C Terminus (BRCT) ...
    PF00533 1757-1841 2.1e-12 BRCA1 C Terminus (BRCT) ...