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IID00070  Histone acetyltransferase p300 (Homo sapiens) Q09472
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
2414
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 323-423 Hetero dimer : IID00085Complex
 Evidence NMR 1l3e B Reference
       Region 1l3e B 323-423 order
       Region 1l3e B 323-327 high_rmsd
       Region 1l3e B 420-423 high_rmsd
Seq 323-423 Hetero dimer : IID00179Complex
 Evidence NMR 1p4q B Reference
       Region 1p4q B 323-423 order
       Region 1p4q B 323-328 high_rmsd
       Region 1p4q B 421-423 high_rmsd
Seqdisorder 401-566
 Evidence NMR Reference
       Region 401-566 disorder
Seq 1040-1161 Monomer :
 Evidence X-RAY 5bt3 A Reference
       Region 5bt3 A 1048-1161 order
 Evidence X-RAY 3i3j A Reference
       Region 3i3j A 1040-1046 disorder
       Region 3i3j A 1047-1160 order
       Region 3i3j A 1161-1161 disorder
 Evidence X-RAY 3i3j J Reference
       Region 3i3j J 1040-1047 disorder
       Region 3i3j J 1048-1160 order
       Region 3i3j J 1161-1161 disorder
 Evidence X-RAY 3i3j K Reference
       Region 3i3j K 1040-1046 disorder
       Region 3i3j K 1047-1160 order
       Region 3i3j K 1161-1161 disorder
 Evidence X-RAY 3i3j L Reference
       Region 3i3j L 1040-1047 disorder
       Region 3i3j L 1048-1160 order
       Region 3i3j L 1161-1161 disorder
 Evidence X-RAY 3i3j B Reference
       Region 3i3j B 1040-1047 disorder
       Region 3i3j B 1048-1161 order
 Evidence X-RAY 3i3j C Reference
       Region 3i3j C 1040-1046 disorder
       Region 3i3j C 1047-1160 order
       Region 3i3j C 1161-1161 disorder
 Evidence X-RAY 3i3j D Reference
       Region 3i3j D 1040-1047 disorder
       Region 3i3j D 1048-1160 order
       Region 3i3j D 1161-1161 disorder
 Evidence X-RAY 3i3j E Reference
       Region 3i3j E 1040-1046 disorder
       Region 3i3j E 1047-1161 order
 Evidence X-RAY 3i3j F Reference
       Region 3i3j F 1040-1048 disorder
       Region 3i3j F 1049-1159 order
       Region 3i3j F 1160-1161 disorder
 Evidence X-RAY 3i3j G Reference
       Region 3i3j G 1040-1047 disorder
       Region 3i3j G 1048-1160 order
       Region 3i3j G 1161-1161 disorder
 Evidence X-RAY 3i3j H Reference
       Region 3i3j H 1040-1047 disorder
       Region 3i3j H 1048-1160 order
       Region 3i3j H 1161-1161 disorder
 Evidence X-RAY 3i3j I Reference
       Region 3i3j I 1040-1046 disorder
       Region 3i3j I 1047-1161 order
 Evidence X-RAY 5lpk A Reference
       Region 5lpk A 1040-1045 disorder
       Region 5lpk A 1046-1161 order
 Evidence X-RAY 5lpk B Reference
       Region 5lpk B 1040-1048 disorder
       Region 5lpk B 1049-1160 order
       Region 5lpk B 1161-1161 disorder
 Evidence X-RAY 5lpk C Reference
       Region 5lpk C 1040-1047 disorder
       Region 5lpk C 1048-1161 order
 Evidence X-RAY 5lpk D Reference
       Region 5lpk D 1040-1046 disorder
       Region 5lpk D 1047-1161 order
 Evidence X-RAY 5lpk E Reference
       Region 5lpk E 1040-1046 disorder
       Region 5lpk E 1047-1159 order
       Region 5lpk E 1160-1161 disorder
 Evidence X-RAY 5lpk F Reference
       Region 5lpk F 1040-1046 disorder
       Region 5lpk F 1047-1161 order
 Evidence X-RAY 5lpk G Reference
       Region 5lpk G 1040-1046 disorder
       Region 5lpk G 1047-1160 order
       Region 5lpk G 1161-1161 disorder
 Evidence X-RAY 5lpm A Reference
       Region 5lpm A 1048-1161 order
 Evidence X-RAY 5lpm B Reference
       Region 5lpm B 1048-1161 order
 Evidence X-RAY 5nu5 A Reference
       Region 5nu5 A 1048-1161 order
 Evidence X-RAY 5nu5 B Reference
       Region 5nu5 B 1048-1161 order
Seq 1043-1519,1581-1666 Hetero dimer :
 Evidence X-RAY 5lkz A Reference
       Region 5lkz A 1043-1045 disorder
       Region 5lkz A 1046-1179 order
       Region 5lkz A 1180-1181 disorder
       Region 5lkz A 1182-1207 order
       Region 5lkz A 1208-1210 disorder
       Region 5lkz A 1211-1216 order
       Region 5lkz A 1217-1222 disorder
       Region 5lkz A 1223-1519 order
       Region 5lkz A 1581-1662 order
       Region 5lkz A 1663-1666 disorder
Seq 1043-1519,1581-1666 Hetero tetramer :
 Evidence X-RAY 4bhw A Reference
       Region 4bhw A 1043-1045 disorder
       Region 4bhw A 1046-1519 order
       Region 4bhw A 1581-1664 order
       Region 4bhw A 1665-1666 disorder
 Evidence X-RAY 4bhw B Reference
       Region 4bhw B 1043-1045 disorder
       Region 4bhw B 1046-1519 order
       Region 4bhw B 1581-1664 order
       Region 4bhw B 1665-1666 disorder
Seq 1043-1519,1581-1666 Hetero dimer :
 Evidence X-RAY 5lkt A Reference
       Region 5lkt A 1043-1045 disorder
       Region 5lkt A 1046-1178 order
       Region 5lkt A 1179-1182 disorder
       Region 5lkt A 1183-1216 order
       Region 5lkt A 1217-1222 disorder
       Region 5lkt A 1223-1519 order
       Region 5lkt A 1581-1662 order
       Region 5lkt A 1663-1666 disorder
Seq 1043-1519,1581-1666 Hetero dimer :
 Evidence X-RAY 5lku A Reference
       Region 5lku A 1043-1047 disorder
       Region 5lku A 1048-1216 order
       Region 5lku A 1217-1222 disorder
       Region 5lku A 1223-1519 order
       Region 5lku A 1581-1661 order
       Region 5lku A 1662-1666 disorder
Seq 1043-1519,1581-1666 Hetero dimer :
 Evidence X-RAY 5lkx A Reference
       Region 5lkx A 1043-1045 disorder
       Region 5lkx A 1046-1216 order
       Region 5lkx A 1217-1222 disorder
       Region 5lkx A 1223-1519 order
       Region 5lkx A 1581-1661 order
       Region 5lkx A 1662-1666 disorder
Seq 1287-1522,1555-1666 Hetero dimer :
 Evidence X-RAY 5kj2 A Reference
       Region 5kj2 A 1287-1522 order
       Region 5kj2 A 1555-1558 order
       Region 5kj2 A 1559-1578 disorder
       Region 5kj2 A 1579-1661 order
       Region 5kj2 A 1662-1666 disorder
Seq 1287-1666 Monomer :
 Evidence X-RAY 3biy A Reference
       Region 3biy A 1287-1519 order
       Region 3biy A 1520-1580 disorder
       Region 3biy A 1581-1664 order
       Region 3biy A 1665-1666 disorder
 Evidence X-RAY 4pzr A Reference
       Region 4pzr A 1287-1532 order
       Region 4pzr A 1533-1578 disorder
       Region 4pzr A 1579-1664 order
 Evidence X-RAY 4pzs A Reference
       Region 4pzs A 1287-1534 order
       Region 4pzs A 1535-1578 disorder
       Region 4pzs A 1579-1664 order
 Evidence X-RAY 4pzt A Reference
       Region 4pzt A 1287-1534 order
       Region 4pzt A 1535-1578 disorder
       Region 4pzt A 1579-1664 order
Seq 1723-1812 Hetero dimer : IID00015Complex
 Evidence NMR 2k8f A Reference
       Region 2k8f A 1723-1812 order
Seq 1723-1812 Hetero dimer : IID00015Complex
 Evidence NMR 2mzd A Reference
       Region 2mzd A 1723-1812 order
       Region 2mzd A 1723-1724 high_rmsd
       Region 2mzd A 1812-1812 high_rmsd
Seq 1723-1812 Hetero dimer : IID00541Complex
 Evidence NMR 2mh0 B Reference
       Region 2mh0 B 1723-1812 order
       Region 2mh0 B 1723-1723 high_rmsd
Seq 1723-1818 Hetero dimer : IID00618Complex
 Evidence X-RAY 3t92 A Reference
       Region 3t92 A 1723-1728 disorder
       Region 3t92 A 1729-1818 order
Seq 1723-1836 Monomer :
 Evidence X-RAY 3io2 A Reference
       Region 3io2 A 1723-1725 disorder
       Region 3io2 A 1726-1834 order
       Region 3io2 A 1835-1836 disorder
Seq 1726-1835 Hetero heptamer : IID00240Complex
 Evidence X-RAY 3p57 P Reference
       Region 3p57 P 1726-1771 order
       Region 3p57 P 1772-1778 disorder
       Region 3p57 P 1779-1835 order
Seqphosphorylation
    89-89 Phosphoserine; by AMPK
    499-499 Phosphoserine
    1038-1038 Phosphoserine
    1726-1726 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    418-418 N6-acetyllysine
    423-423 N6-acetyllysine
    636-636 N6-acetyllysine
    977-977 N6-acetyllysine
    1020-1020 N6-acetyllysine; alternate
    1024-1024 N6-acetyllysine; alternate
    1180-1180 N6-acetyllysine
    1336-1336 N6-acetyllysine
    1473-1473 N6-acetyllysine
    1499-1499 N6-acetyllysine; by autocatalysis
    1542-1542 N6-acetyllysine
    1546-1546 N6-acetyllysine
    1549-1549 N6-acetyllysine; by autocatalysis
    1554-1554 N6-acetyllysine; by autocatalysis
    1555-1555 N6-acetyllysine
    1558-1558 N6-acetyllysine
    1560-1560 N6-acetyllysine; by autocatalysis
    1583-1583 N6-acetyllysine
    1699-1699 N6-acetyllysine
    1704-1704 N6-acetyllysine
    1707-1707 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-322,424-567,646-1045,1513-1566,1714-1722,1811-2074,2096-2414
Known Domain 323-423,568-645,1046-1512,1567-1713,1723-1810,2075-2095
SCOPe RPS-Blast
     1l8cA 330-424 1e-37 g.53.1.1 CREB-binding transcriptional adaptor pr...
     4i9oA 568-645 3e-34 a.12.1.1 Kix domain of CBP (creb binding protei...
     4nyxA 1046-1161 3e-62 a.29.2.1 CREB-binding protein, CBP
     2n1aB 1663-1714 4e-26 g.44.1.6 CREB-binding protein, CBP
     1f81A 1726-1812 1e-35 g.53.1.1 CREB-binding transcriptional adaptor ...
     1zoqC 2050-2095 1e-09 a.153.1.1 Nuclear receptor coactivator 1, NCO...
SCOP Hmmer
     1l3eB_ 326-421 5.2e-31 g.53.1.1 CREB-binding tr...
     1sb0A_ 567-651 2.2e-38 a.12.1.1 Kix domain of C...
     1eqfA1 1035-1161 1.5e-37 a.29.2.1 CREB-binding ...
     1totA1 1663-1709 2.6e-15 g.44.1.6 CREB-binding ...
     1f81A_ 1727-1812 1.2e-26 g.53.1.1 CREB-binding ...
     1kbhB_ 2043-2098 1.5e-27 a.153.1.1 Nuclear rece...
Pfam RPS-Blast
     PF02135 339-420 2e-17 TAZ zinc finger
     PF02172 569-605 5e-09 KIX domain
     PF03154 657-975 2e-09 Atrophin-1 family
     PF00439 1058-1142 3e-12 Bromodomain
     PF06001 1156-1195 1e-18 Domain of Unknown Functio...
     PF08214 1322-1558 1e-56 Histone acetylation prote...
     PF00569 1668-1705 7e-08 Zinc finger, ZZ type
     PF02135 1736-1815 2e-26 TAZ zinc finger
     PF07174 1844-1929 8e-05 Fibronectin-attachment pr...
     PF12851 1940-2363 1e-06 Oxygenase domain of the 2...
Pfam Hmmer
    PF02135 338-414 1.9e-22 TAZ zinc finger
    PF02172 567-646 1.7e-43 KIX domain
    PF00439 1068-1143 1.4e-19 Bromodomain
    PF06001 1156-1195 1.2e-25 Domain of Unknown Functi...
    PF08214 1306-1609 1.1e-73 Histone acetylation prot...
    PF00569 1665-1705 2.7e-18 Zinc finger, ZZ type
    PF02135 1735-1806 2.6e-15 TAZ zinc finger
    PF09030 1992-2098 7.2e-37 Creb binding