Search Keyword:


Search option:


IID00085  Hypoxia-inducible factor 1-alpha (Homo sapiens) Q16665
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
826
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 238-348 Hetero dimer : P27540
 Evidence X-RAY 4h6j A Reference
       Region 4h6j A 238-343 order
       Region 4h6j A 344-348 disorder
Seq 395-411 Hetero dimer : IID00345Complex
 Evidence X-RAY 5la9 C Reference
       Region 5la9 C 395-411 order
 Evidence X-RAY 5la9 D Reference
       Region 5la9 D 395-411 order
Seq 395-411 Hetero tetramer : IID00345Complex
 Evidence X-RAY 5las C Reference
       Region 5las C 395-411 order
 Evidence X-RAY 5las D Reference
       Region 5las D 395-411 order
 Evidence X-RAY 5l9v C Reference
       Region 5l9v C 395-411 order
 Evidence X-RAY 5l9v D Reference
       Region 5l9v D 395-411 order
Seqdisorder 403-698
 Evidence CD Reference
       Region 403-603 disorder
       Region 530-698 disorder
Seq 549-582 Hetero tetramer : IID00371Complex
 Evidence X-RAY 1lm8 H Reference
       Region 1lm8 H 556-560 disorder
       Region 1lm8 H 561-575 order
 Evidence X-RAY 1lqb D Reference
       Region 1lqb D 549-559 disorder
       Region 1lqb D 560-577 order
       Region 1lqb D 578-582 disorder
 Evidence X-RAY 4ajy H Reference
       Region 4ajy H 559-559 disorder
       Region 4ajy H 560-574 order
       Region 4ajy H 575-577 disorder
Seq 556-574 Hetero dimer : IID00345Complex
 Evidence X-RAY 3hqr S Reference
       Region 3hqr S 558-574 order
 Evidence X-RAY 5l9b C Reference
       Region 5l9b C 556-556 disorder
       Region 5l9b C 557-574 order
 Evidence X-RAY 5l9b D Reference
       Region 5l9b D 556-556 disorder
       Region 5l9b D 557-574 order
Seq 558-574 Hetero dimer : IID00345Complex
 Evidence X-RAY 3hqu S Reference
       Region 3hqu S 558-567 disorder
       Region 3hqu S 568-574 order
Seq 775-826 Hetero tetramer : IID00396Complex
 Evidence X-RAY 1h2k S Reference
       Region 1h2k S 786-794 disorder
       Region 1h2k S 795-806 order
       Region 1h2k S 807-811 disorder
       Region 1h2k S 812-823 order
       Region 1h2k S 824-826 disorder
 Evidence X-RAY 1h2l S Reference
       Region 1h2l S 786-794 disorder
       Region 1h2l S 795-806 order
       Region 1h2l S 807-812 disorder
       Region 1h2l S 813-822 order
       Region 1h2l S 823-826 disorder
 Evidence X-RAY 1h2m S Reference
       Region 1h2m S 775-794 disorder
       Region 1h2m S 795-806 order
       Region 1h2m S 807-812 disorder
       Region 1h2m S 813-822 order
       Region 1h2m S 823-826 disorder
Seqdisorder 776-826
 Evidence NMR Reference
       Region 776-826 disorder
Seq 776-826 Hetero dimer : IID50008Complex
 Evidence NMR 1l8c B Reference
       Region 1l8c B 776-826 order
       Region 1l8c B 776-777 high_rmsd
Seq 786-826 Hetero tetramer : IID00396Complex
 Evidence X-RAY 2ilm S Reference
       Region 2ilm S 786-793 disorder
       Region 2ilm S 794-799 order
       Region 2ilm S 800-826 disorder
Seq 786-826 Hetero dimer : IID00070Complex
 Evidence NMR 1l3e A Reference
       Region 1l3e A 786-826 order
       Region 1l3e A 786-789 high_rmsd
Seq 788-806 Hetero tetramer : IID00396Complex
 Evidence X-RAY 5jwp B Reference
       Region 5jwp B 788-793 disorder
       Region 5jwp B 794-806 order
SeqProS verified 395-411 Hetero tetramer : IID00345Complex
       Region 5l9v C 395-411 order
       Region 5l9v D 395-411 order
       Region 5las C 395-411 order
       Region 5las D 395-411 order
       Region 530-698 disorder
SeqProS verified 395-411 Hetero dimer : IID00345Complex
       Region 5la9 C 395-411 order
       Region 5la9 D 395-411 order
       Region 530-698 disorder
SeqProS verified 557-574 Hetero dimer : IID00345Complex
       Region 3hqr S 558-574 order
       Region 5l9b C 557-574 order
       Region 5l9b D 557-574 order
       Region 530-698 disorder
SeqProS verified 560-577 Hetero tetramer : IID00371Complex
       Region 1lqb D 560-577 order
       Region 4ajy H 560-574 order
       Region 1lm8 H 561-575 order
       Region 530-698 disorder
SeqProS verified 568-574 Hetero dimer : IID00345Complex
       Region 3hqu S 568-574 order
       Region 530-698 disorder
SeqProS verified 776-826 Hetero dimer : IID50008Complex
       Region 1l8c B 776-826 order
       Region 776-826 disorder
SeqProS verified 786-826 Hetero dimer : IID00070Complex
       Region 1l3e A 786-826 order
       Region 776-826 disorder
SeqProS verified 794-799 Hetero tetramer : IID00396Complex
       Region 2ilm S 794-799 order
       Region 776-826 disorder
SeqProS verified 794-806 Hetero tetramer : IID00396Complex
       Region 5jwp B 794-806 order
       Region 776-826 disorder
SeqProS verified 795-806,812-823 Hetero tetramer : IID00396Complex
       Region 1h2k S 795-806 order
       Region 1h2l S 795-806 order
       Region 1h2m S 795-806 order
       Region 1h2k S 812-823 order
       Region 1h2l S 813-822 order
       Region 1h2m S 813-822 order
       Region 776-826 disorder
Seqphosphorylation
    247-247 Phosphoserine; by CK1
    551-551 Phosphoserine; by GSK3-beta
    555-555 Phosphothreonine; by GSK3-beta
    576-576 Phosphoserine; by PLK3
    589-589 Phosphoserine; by GSK3-beta
    657-657 Phosphoserine; by PLK3
Seqacetylation
    532-532 N6-acetyllysine
    709-709 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-14,70-90,228-237,344-826
Known Domain 15-69,91-227,238-343
SCOPe RPS-Blast
     4wn5A1 239-343 4e-52 d.110.3.0 automated matches
SCOP Hmmer
     1am9A_ 15-69 9.1e-10 a.38.1.1 Mad protein
     1oj5A_ 96-207 2.2e-19 d.110.3.8 PAS domain of s...
     1oj5A_ 242-343 4.6e-31 d.110.3.8 PAS domain of ...
Pfam RPS-Blast
     PF14598 99-210 7e-04 PAS domain
     PF14598 241-343 4e-26 PAS domain
     PF11413 556-581 4e-05 Hypoxia-inducible factor-1
     PF08778 790-825 8e-14 HIF-1 alpha C terminal tran...
Pfam Hmmer
    PF00989 94-150 8.4e-09 PAS fold
    PF08447 254-339 4.5e-25 PAS fold
    PF11413 551-580 1.1e-18 Hypoxia-inducible factor-1
    PF08778 790-825 2.4e-25 HIF-1 alpha C terminal tra...