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IID00092  CREB-binding protein (Homo sapiens) Q92793
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
2442
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 58-80 Hetero tetramer : IID00041Complex
 Evidence X-RAY 1rdt E Reference
       Region 1rdt E 58-67 disorder
       Region 1rdt E 68-74 order
       Region 1rdt E 75-80 disorder
Seq 376-402 Monomer :
 Evidence NMR 1liq A Reference
       Region 1liq A 376-402 order
 Evidence NMR 1wo6 A Reference
       Region 1wo6 A 376-400 order
 Evidence NMR 1wo7 A Reference
       Region 1wo7 A 376-400 order
Seq 387-398 Monomer :
 Evidence NMR 1wo3 A Reference
       Region 1wo3 A 387-398 order
 Evidence NMR 1wo4 A Reference
       Region 1wo4 A 387-398 order
 Evidence NMR 1wo5 A Reference
       Region 1wo5 A 387-398 order
Seq 587-673 Hetero dimer : IID00622Complex
 Evidence NMR 2kwf A Reference
       Region 2kwf A 587-673 order
       Region 2kwf A 587-588 high_rmsd
Seq 587-673 Hetero trimer : IID00379Complex,IID00442Complex
 Evidence NMR 2lxt A Reference
       Region 2lxt A 587-673 order
       Region 2lxt A 587-591 high_rmsd
       Region 2lxt A 673-673 high_rmsd
Seq 587-673 Hetero dimer : IID00379Complex
 Evidence NMR 2lxs A Reference
       Region 2lxs A 587-673 order
       Region 2lxs A 587-590 high_rmsd
       Region 2lxs A 673-673 high_rmsd
Seq 1080-1316 Hetero dimer : IID00058Complex
 Evidence X-RAY 4n3w A Reference
       Region 4n3w A 1080-1081 disorder
       Region 4n3w A 1082-1212 order
       Region 4n3w A 1213-1252 disorder
       Region 4n3w A 1253-1261 order
       Region 4n3w A 1262-1268 disorder
       Region 4n3w A 1269-1312 order
       Region 4n3w A 1313-1316 disorder
Seq 1080-1316 Hetero dimer : IID00058Complex
 Evidence X-RAY 4n4f A Reference
       Region 4n4f A 1080-1080 disorder
       Region 4n4f A 1081-1213 order
       Region 4n4f A 1214-1247 disorder
       Region 4n4f A 1248-1261 order
       Region 4n4f A 1262-1268 disorder
       Region 4n4f A 1269-1312 order
       Region 4n4f A 1313-1316 disorder
Seq 1081-1196 Hetero dimer : IID00062Complex
 Evidence X-RAY 5gh9 A Reference
       Region 5gh9 A 1081-1083 disorder
       Region 5gh9 A 1084-1196 order
Seq 1081-1197 Monomer :
 Evidence X-RAY 4a9k A Reference
       Region 4a9k A 1081-1082 disorder
       Region 4a9k A 1083-1197 order
 Evidence X-RAY 4a9k B Reference
       Region 4a9k B 1081-1084 disorder
       Region 4a9k B 1085-1196 order
       Region 4a9k B 1197-1197 disorder
 Evidence X-RAY 6axq A Reference
       Region 6axq A 1085-1196 order
 Evidence X-RAY 6axq B Reference
       Region 6axq B 1085-1196 order
 Evidence X-RAY 6axq C Reference
       Region 6axq C 1085-1196 order
 Evidence X-RAY 6axq D Reference
       Region 6axq D 1085-1196 order
 Evidence X-RAY 6ay3 A Reference
       Region 6ay3 A 1083-1197 order
 Evidence X-RAY 6ay3 B Reference
       Region 6ay3 B 1083-1197 order
 Evidence X-RAY 6ay5 A Reference
       Region 6ay5 A 1083-1197 order
 Evidence X-RAY 5cgp A Reference
       Region 5cgp A 1081-1082 disorder
       Region 5cgp A 1083-1197 order
 Evidence X-RAY 5dbm A Reference
       Region 5dbm A 1082-1082 disorder
       Region 5dbm A 1083-1196 order
       Region 5dbm A 1197-1197 disorder
 Evidence X-RAY 5dbm B Reference
       Region 5dbm B 1082-1083 disorder
       Region 5dbm B 1084-1196 order
       Region 5dbm B 1197-1197 disorder
 Evidence X-RAY 5dbm C Reference
       Region 5dbm C 1082-1197 order
 Evidence X-RAY 3dwy A Reference
       Region 3dwy A 1081-1083 disorder
       Region 3dwy A 1084-1197 order
 Evidence X-RAY 3dwy B Reference
       Region 3dwy B 1081-1084 disorder
       Region 3dwy B 1085-1196 order
       Region 3dwy B 1197-1197 disorder
 Evidence X-RAY 5eic A Reference
       Region 5eic A 1081-1083 disorder
       Region 5eic A 1084-1196 order
       Region 5eic A 1197-1197 disorder
 Evidence X-RAY 5eic B Reference
       Region 5eic B 1081-1196 order
       Region 5eic B 1197-1197 disorder
 Evidence X-RAY 5ep7 A Reference
       Region 5ep7 A 1081-1197 order
 Evidence X-RAY 5h85 A Reference
       Region 5h85 A 1081-1197 order
 Evidence X-RAY 5i83 A Reference
       Region 5i83 A 1082-1082 disorder
       Region 5i83 A 1083-1196 order
       Region 5i83 A 1197-1197 disorder
 Evidence X-RAY 5i86 A Reference
       Region 5i86 A 1082-1196 order
       Region 5i86 A 1197-1197 disorder
 Evidence X-RAY 5i86 B Reference
       Region 5i86 B 1082-1082 disorder
       Region 5i86 B 1083-1196 order
       Region 5i86 B 1197-1197 disorder
 Evidence X-RAY 5i89 A Reference
       Region 5i89 A 1082-1082 disorder
       Region 5i89 A 1083-1197 order
 Evidence X-RAY 5j0d A Reference
       Region 5j0d A 1081-1197 order
 Evidence X-RAY 5ktu A Reference
       Region 5ktu A 1082-1088 disorder
       Region 5ktu A 1089-1195 order
       Region 5ktu A 1196-1197 disorder
 Evidence X-RAY 5ktu B Reference
       Region 5ktu B 1082-1083 disorder
       Region 5ktu B 1084-1196 order
       Region 5ktu B 1197-1197 disorder
 Evidence X-RAY 5ktw A Reference
       Region 5ktw A 1085-1194 order
 Evidence X-RAY 5ktw B Reference
       Region 5ktw B 1085-1194 order
 Evidence X-RAY 5ktw C Reference
       Region 5ktw C 1085-1194 order
 Evidence X-RAY 5ktx A Reference
       Region 5ktx A 1085-1194 order
 Evidence NMR 2l84 A Reference
       Region 2l84 A 1081-1197 order
 Evidence NMR 2l85 A Reference
       Region 2l85 A 1081-1197 order
 Evidence X-RAY 5lpj A Reference
       Region 5lpj A 1081-1081 disorder
       Region 5lpj A 1082-1197 order
 Evidence X-RAY 5lpl A Reference
       Region 5lpl A 1081-1197 order
 Evidence X-RAY 5mme A Reference
       Region 5mme A 1081-1197 order
 Evidence X-RAY 5mme B Reference
       Region 5mme B 1081-1197 order
 Evidence X-RAY 5mmg A Reference
       Region 5mmg A 1081-1082 disorder
       Region 5mmg A 1083-1197 order
 Evidence X-RAY 5mpk A Reference
       Region 5mpk A 1081-1083 disorder
       Region 5mpk A 1084-1195 order
       Region 5mpk A 1196-1197 disorder
 Evidence X-RAY 5mpk B Reference
       Region 5mpk B 1081-1083 disorder
       Region 5mpk B 1084-1195 order
       Region 5mpk B 1196-1197 disorder
 Evidence X-RAY 5mpn A Reference
       Region 5mpn A 1081-1196 order
       Region 5mpn A 1197-1197 disorder
 Evidence X-RAY 5mpz A Reference
       Region 5mpz A 1081-1083 disorder
       Region 5mpz A 1084-1193 order
       Region 5mpz A 1194-1197 disorder
 Evidence X-RAY 5mqe A Reference
       Region 5mqe A 1081-1082 disorder
       Region 5mqe A 1083-1196 order
       Region 5mqe A 1197-1197 disorder
 Evidence X-RAY 5mqe B Reference
       Region 5mqe B 1081-1083 disorder
       Region 5mqe B 1084-1195 order
       Region 5mqe B 1196-1197 disorder
 Evidence X-RAY 5mqg A Reference
       Region 5mqg A 1081-1081 disorder
       Region 5mqg A 1082-1197 order
 Evidence X-RAY 5mqg B Reference
       Region 5mqg B 1081-1083 disorder
       Region 5mqg B 1084-1196 order
       Region 5mqg B 1197-1197 disorder
 Evidence X-RAY 5mqk A Reference
       Region 5mqk A 1081-1197 order
 Evidence X-RAY 5mqk B Reference
       Region 5mqk B 1081-1082 disorder
       Region 5mqk B 1083-1197 order
 Evidence X-RAY 5nlk A Reference
       Region 5nlk A 1081-1082 disorder
       Region 5nlk A 1083-1197 order
 Evidence X-RAY 4nr4 A Reference
       Region 4nr4 A 1081-1084 disorder
       Region 4nr4 A 1085-1197 order
 Evidence X-RAY 4nr4 B Reference
       Region 4nr4 B 1081-1085 disorder
       Region 4nr4 B 1086-1197 order
 Evidence X-RAY 4nr5 A Reference
       Region 4nr5 A 1081-1082 disorder
       Region 4nr5 A 1083-1195 order
       Region 4nr5 A 1196-1197 disorder
 Evidence X-RAY 4nr6 A Reference
       Region 4nr6 A 1081-1081 disorder
       Region 4nr6 A 1082-1197 order
 Evidence X-RAY 4nr7 A Reference
       Region 4nr7 A 1081-1081 disorder
       Region 4nr7 A 1082-1197 order
 Evidence X-RAY 5nrw A Reference
       Region 5nrw A 1081-1082 disorder
       Region 5nrw A 1083-1197 order
 Evidence X-RAY 5nu3 A Reference
       Region 5nu3 A 1081-1197 order
 Evidence X-RAY 4nyv A Reference
       Region 4nyv A 1081-1196 order
       Region 4nyv A 1197-1197 disorder
 Evidence X-RAY 4nyv B Reference
       Region 4nyv B 1081-1081 disorder
       Region 4nyv B 1082-1196 order
       Region 4nyv B 1197-1197 disorder
 Evidence X-RAY 4nyv C Reference
       Region 4nyv C 1081-1082 disorder
       Region 4nyv C 1083-1196 order
       Region 4nyv C 1197-1197 disorder
 Evidence X-RAY 4nyv D Reference
       Region 4nyv D 1081-1082 disorder
       Region 4nyv D 1083-1196 order
       Region 4nyv D 1197-1197 disorder
 Evidence X-RAY 4nyw A Reference
       Region 4nyw A 1081-1081 disorder
       Region 4nyw A 1082-1197 order
 Evidence X-RAY 4nyx A Reference
       Region 4nyx A 1081-1081 disorder
       Region 4nyx A 1082-1197 order
 Evidence X-RAY 4ouf A Reference
       Region 4ouf A 1082-1082 disorder
       Region 4ouf A 1083-1196 order
       Region 4ouf A 1197-1197 disorder
 Evidence X-RAY 4ouf B Reference
       Region 4ouf B 1082-1083 disorder
       Region 4ouf B 1084-1195 order
       Region 4ouf B 1196-1197 disorder
 Evidence X-RAY 3p1c A Reference
       Region 3p1c A 1081-1082 disorder
       Region 3p1c A 1083-1197 order
 Evidence X-RAY 3p1c B Reference
       Region 3p1c B 1081-1084 disorder
       Region 3p1c B 1085-1196 order
       Region 3p1c B 1197-1197 disorder
 Evidence X-RAY 3p1d A Reference
       Region 3p1d A 1081-1082 disorder
       Region 3p1d A 1083-1197 order
 Evidence X-RAY 3p1d B Reference
       Region 3p1d B 1081-1082 disorder
       Region 3p1d B 1083-1196 order
       Region 3p1d B 1197-1197 disorder
 Evidence X-RAY 3p1e A Reference
       Region 3p1e A 1081-1082 disorder
       Region 3p1e A 1083-1196 order
       Region 3p1e A 1197-1197 disorder
 Evidence X-RAY 3p1e B Reference
       Region 3p1e B 1081-1084 disorder
       Region 3p1e B 1085-1196 order
       Region 3p1e B 1197-1197 disorder
 Evidence X-RAY 3p1f A Reference
       Region 3p1f A 1081-1197 order
 Evidence X-RAY 3p1f B Reference
       Region 3p1f B 1081-1082 disorder
       Region 3p1f B 1083-1197 order
 Evidence X-RAY 3svh A Reference
       Region 3svh A 1081-1197 order
 Evidence X-RAY 3svh B Reference
       Region 3svh B 1081-1197 order
 Evidence X-RAY 4tqn A Reference
       Region 4tqn A 1081-1083 disorder
       Region 4tqn A 1084-1195 order
       Region 4tqn A 1196-1197 disorder
 Evidence X-RAY 4ts8 A Reference
       Region 4ts8 A 1081-1084 disorder
       Region 4ts8 A 1085-1196 order
       Region 4ts8 A 1197-1197 disorder
 Evidence X-RAY 5w0e A Reference
       Region 5w0e A 1082-1082 disorder
       Region 5w0e A 1083-1196 order
       Region 5w0e A 1197-1197 disorder
 Evidence X-RAY 5w0f A Reference
       Region 5w0f A 1082-1082 disorder
       Region 5w0f A 1083-1196 order
       Region 5w0f A 1197-1197 disorder
 Evidence X-RAY 5w0l A Reference
       Region 5w0l A 1082-1082 disorder
       Region 5w0l A 1083-1196 order
       Region 5w0l A 1197-1197 disorder
 Evidence X-RAY 5w0l B Reference
       Region 5w0l B 1082-1082 disorder
       Region 5w0l B 1083-1196 order
       Region 5w0l B 1197-1197 disorder
 Evidence X-RAY 5w0q A Reference
       Region 5w0q A 1082-1197 order
 Evidence X-RAY 4whu A Reference
       Region 4whu A 1081-1197 order
 Evidence X-RAY 4yk0 A Reference
       Region 4yk0 A 1083-1083 disorder
       Region 4yk0 A 1084-1196 order
 Evidence X-RAY 4yk0 B Reference
       Region 4yk0 B 1083-1083 disorder
       Region 4yk0 B 1084-1196 order
 Evidence X-RAY 4yk0 C Reference
       Region 4yk0 C 1083-1088 disorder
       Region 4yk0 C 1089-1147 order
       Region 4yk0 C 1148-1149 disorder
       Region 4yk0 C 1150-1189 order
       Region 4yk0 C 1190-1196 disorder
 Evidence X-RAY 4yk0 D Reference
       Region 4yk0 D 1083-1094 disorder
       Region 4yk0 D 1095-1147 order
       Region 4yk0 D 1148-1149 disorder
       Region 4yk0 D 1150-1187 order
       Region 4yk0 D 1188-1196 disorder
 Evidence NMR 2d82 A Reference
       Region 2d82 A 1081-1197 order
 Evidence X-RAY 5eng A Reference
       Region 5eng A 1081-1082 disorder
       Region 5eng A 1083-1196 order
       Region 5eng A 1197-1197 disorder
 Evidence X-RAY 5tb6 A Reference
       Region 5tb6 A 1081-1197 order
Seq 1081-1197 Hetero dimer : IID00015Complex
 Evidence NMR 1jsp B Reference
       Region 1jsp B 1081-1197 order
       Region 1jsp B 1120-1120 high_rmsd
Seq 1081-1197 Hetero dimer : IID00058Complex
 Evidence NMR 2rny A Reference
       Region 2rny A 1081-1197 order
Seq 1081-1312 Monomer :
 Evidence X-RAY 5i8b A Reference
       Region 5i8b A 1081-1241 order
       Region 5i8b A 1242-1249 disorder
       Region 5i8b A 1250-1312 order
 Evidence X-RAY 5i8g A Reference
       Region 5i8g A 1081-1241 order
       Region 5i8g A 1242-1249 disorder
       Region 5i8g A 1250-1312 order
Seq 1699-1751 Hetero dimer : IID00378Complex
 Evidence NMR 2n1a B Reference
       Region 2n1a B 1699-1751 order
       Region 2n1a B 1751-1751 high_rmsd
Seq 1763-1854 Hetero dimer : IID90003Complex
 Evidence NMR 2kje A Reference
       Region 2kje A 1763-1854 order
Seq 2065-2111 Hetero dimer : IID00079Complex
 Evidence X-RAY 1zoq C Reference
       Region 1zoq C 2065-2111 order
 Evidence X-RAY 1zoq D Reference
       Region 1zoq D 2065-2111 order
Seq 2065-2111 Hetero tetramer : IID00079Complex
 Evidence X-RAY 5jem F Reference
       Region 5jem F 2065-2106 order
       Region 5jem F 2107-2111 disorder
 Evidence X-RAY 5jem H Reference
       Region 5jem H 2065-2106 order
       Region 5jem H 2107-2111 disorder
Seq 2065-2111 Hetero tetramer : IID00079Complex
 Evidence X-RAY 5jem C Reference
       Region 5jem C 2065-2106 order
       Region 5jem C 2107-2111 disorder
 Evidence X-RAY 5jem D Reference
       Region 5jem D 2065-2106 order
       Region 5jem D 2107-2111 disorder
SeqProS possible 68-74 LXXLL motif Hetero tetramer : IID00041Complex
       Region 1rdt E 68-74 order
SeqProS possible 2065-2111 Same region of mouse homolog (P45481, 100% identity) is disordered in the free state. Hetero dimer : IID00079Complex
       Region 1zoq C 2065-2111 order
       Region 1zoq D 2065-2111 order
Seqphosphorylation
    121-121 Phosphoserine
    1030-1030 Phosphoserine
    1076-1076 Phosphoserine
    1382-1382 Phosphoserine; by IKKA
    1386-1386 Phosphoserine; by IKKA
    1763-1763 Phosphoserine
    2063-2063 Phosphoserine
    2076-2076 Phosphoserine
    2079-2079 Phosphoserine
    2351-2351 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    657-657 N6-acetyllysine
    1014-1014 N6-acetyllysine
    1216-1216 N6-acetyllysine
    1583-1583 N6-acetyllysine
    1591-1591 N6-acetyllysine
    1592-1592 N6-acetyllysine
    1595-1595 N6-acetyllysine
    1597-1597 N6-acetyllysine
    1741-1741 N6-acetyllysine
    1744-1744 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-345,441-588,667-734,869-1081,1550-1603,1751-1760,1846-2064,2112-2442
Known Domain 346-440,589-666,735-868,1082-1549,1604-1750,1761-1845,2065-2111
SCOPe RPS-Blast
     1l8cA 346-440 4e-39 g.53.1.1 CREB-binding transcriptional adaptor pr...
     4i9oA 589-666 9e-35 a.12.1.1 Kix domain of CBP (creb binding protei...
     4nyxA 1082-1197 2e-62 a.29.2.1 CREB-binding protein, CBP
     2n1aB 1699-1751 8e-27 g.44.1.6 CREB-binding protein, CBP
     1f81A 1763-1849 4e-37 g.53.1.1 CREB-binding transcriptional adaptor ...
     1zoqC 2065-2111 1e-12 a.153.1.1 Nuclear receptor coactivator 1, NCO...
SCOP Hmmer
     1l3eB_ 344-438 1.9e-30 g.53.1.1 CREB-binding tr...
     1sb0A_ 589-672 1e-38 a.12.1.1 Kix domain of CBP...
     1eqfA1 1072-1197 7.8e-38 a.29.2.1 CREB-binding ...
     1totA1 1700-1747 3.1e-15 g.44.1.6 CREB-binding ...
     1f81A_ 1764-1848 4.5e-26 g.53.1.1 CREB-binding ...
     1kbhB_ 2059-2115 6.3e-29 a.153.1.1 Nuclear rece...
Pfam RPS-Blast
     PF15967 76-324 7e-06 Nucleoporin FG repeated regi...
     PF02135 355-436 3e-17 TAZ zinc finger
     PF02172 590-626 2e-09 KIX domain
     PF03154 676-1024 2e-09 Atrophin-1 family
     PF00439 1094-1176 3e-12 Bromodomain
     PF06001 1192-1231 5e-19 Domain of Unknown Functio...
     PF08214 1359-1595 3e-57 Histone acetylation prote...
     PF00569 1705-1742 2e-08 Zinc finger, ZZ type
     PF02135 1773-1852 2e-26 TAZ zinc finger
     PF03154 2044-2399 2e-08 Atrophin-1 family
Pfam Hmmer
    PF02135 354-430 3.1e-22 TAZ zinc finger
    PF02172 588-667 3.2e-42 KIX domain
    PF00439 1104-1177 9.4e-20 Bromodomain
    PF06001 1192-1231 1.7e-25 Domain of Unknown Functi...
    PF08214 1342-1640 4.2e-72 Histone acetylation prot...
    PF00569 1702-1742 1.1e-18 Zinc finger, ZZ type
    PF02135 1772-1843 2.2e-15 TAZ zinc finger
    PF09030 2020-2113 3.9e-37 Creb binding