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IID00109  Nuclear receptor corepressor 2 (Homo sapiens) Q9Y618
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
2525
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 167-207 Hetero dimer : IID00320Complex
 Evidence NMR 2l5g B Reference
       Region 2l5g B 167-207 order
       Region 2l5g B 207-207 high_rmsd
Seq 389-480 Hetero dimer : IID00428Complex
 Evidence X-RAY 4a69 C Reference
       Region 4a69 C 389-407 disorder
       Region 4a69 C 408-476 order
       Region 4a69 C 477-480 disorder
 Evidence X-RAY 4a69 D Reference
       Region 4a69 D 389-407 disorder
       Region 4a69 D 408-475 order
       Region 4a69 D 476-480 disorder
Seq 412-480 Monomer :
 Evidence NMR 1xc5 A Reference
       Region 1xc5 A 412-412 disorder
       Region 1xc5 A 413-480 order
       Region 1xc5 A 413-417 high_rmsd
       Region 1xc5 A 480-480 high_rmsd
Seq 615-685 Monomer :
 Evidence NMR 2ltp A Reference
       Region 2ltp A 615-685 order
       Region 2ltp A 659-660 high_rmsd
       Region 2ltp A 683-685 high_rmsd
Seq 1109-1121 Hetero dimer : IID00381Complex
 Evidence NMR 2odd B Reference
       Region 2odd B 1109-1121 order
Seq 1422-1438 Hetero tetramer : IID00372Complex
 Evidence X-RAY 1r2b C Reference
       Region 1r2b C 1422-1438 order
 Evidence X-RAY 1r2b D Reference
       Region 1r2b D 1422-1438 order
Seq 2346-2361 Hetero hexamer : IID00031Complex
 Evidence X-RAY 3r2a E Reference
       Region 3r2a E 2346-2346 disorder
       Region 3r2a E 2347-2353 order
       Region 3r2a E 2354-2361 disorder
 Evidence X-RAY 3r2a F Reference
       Region 3r2a F 2346-2354 order
       Region 3r2a F 2355-2361 disorder
Seq 2346-2361 Hetero octamer : IID00031Complex
 Evidence X-RAY 3r29 C Reference
       Region 3r29 C 2346-2361 order
 Evidence X-RAY 3r29 D Reference
       Region 3r29 D 2346-2348 disorder
       Region 3r29 D 2349-2359 order
       Region 3r29 D 2360-2361 disorder
Seq 2346-2362 Hetero dimer : P06401
 Evidence X-RAY 4oar B Reference
       Region 4oar B 2346-2348 disorder
       Region 4oar B 2349-2359 order
       Region 4oar B 2360-2362 disorder
Seq 2346-2367 Hetero dimer : G1RH57
 Evidence X-RAY 5x8x B Reference
       Region 5x8x B 2346-2346 disorder
       Region 5x8x B 2347-2359 order
       Region 5x8x B 2360-2367 disorder
 Evidence X-RAY 5x8x D Reference
       Region 5x8x D 2346-2360 order
       Region 5x8x D 2361-2367 disorder
 Evidence X-RAY 5x8x F Reference
       Region 5x8x F 2346-2359 order
       Region 5x8x F 2360-2367 disorder
 Evidence X-RAY 5x8x H Reference
       Region 5x8x H 2346-2360 order
       Region 5x8x H 2361-2367 disorder
Seq 2346-2367 Hetero nonamer : IID00057Complex
 Evidence X-RAY 2gpv G Reference
       Region 2gpv G 2346-2348 disorder
       Region 2gpv G 2349-2360 order
       Region 2gpv G 2361-2367 disorder
 Evidence X-RAY 2gpv H Reference
       Region 2gpv H 2346-2348 disorder
       Region 2gpv H 2349-2360 order
       Region 2gpv H 2361-2367 disorder
 Evidence X-RAY 2gpv I Reference
       Region 2gpv I 2346-2348 disorder
       Region 2gpv I 2349-2360 order
       Region 2gpv I 2361-2367 disorder
Seq 2346-2367 Hetero dimer : IID00305Complex
 Evidence X-RAY 5x8q B Reference
       Region 5x8q B 2346-2360 order
       Region 5x8q B 2361-2367 disorder
 Evidence X-RAY 5x8q D Reference
       Region 5x8q D 2346-2346 disorder
       Region 5x8q D 2347-2360 order
       Region 5x8q D 2361-2367 disorder
 Evidence X-RAY 5x8q F Reference
       Region 5x8q F 2346-2346 disorder
       Region 5x8q F 2347-2360 order
       Region 5x8q F 2361-2367 disorder
 Evidence X-RAY 5x8q H Reference
       Region 5x8q H 2346-2360 order
       Region 5x8q H 2361-2367 disorder
Seq 2347-2365 Hetero dimer : IID00382Complex
 Evidence X-RAY 1kkq E Reference
       Region 1kkq E 2347-2365 order
 Evidence X-RAY 1kkq F Reference
       Region 1kkq F 2347-2365 order
 Evidence X-RAY 1kkq G Reference
       Region 1kkq G 2347-2365 order
 Evidence X-RAY 1kkq H Reference
       Region 1kkq H 2347-2365 order
Seq 2518-2525 Hetero dimer : IID00578Complex
 Evidence NMR 2rt5 B Reference
       Region 2rt5 B 2518-2525 order
SeqProS possible 167-207 This region is described to be disordered in the free state (PubMed=21240272). Hetero dimer : IID00320Complex
       Region 2l5g B 167-207 order
SeqProS possible 1109-1121 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. Hetero dimer : IID00381Complex
       Region 2odd B 1109-1121 order
SeqProS possible 1422-1438 PubMed=14690607 tells "CD indicates that the unliganded SMRT fragment is unstructures.", but no reference is cited. Hetero tetramer : IID00372Complex
       Region 1r2b C 1422-1438 order
       Region 1r2b D 1422-1438 order
SeqProS possible 2346-2354 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. Hetero hexamer : IID00031Complex
       Region 3r2a E 2347-2353 order
       Region 3r2a F 2346-2354 order
SeqProS possible 2346-2360 Hetero dimer : IID00305Complex
       Region 5x8q B 2346-2360 order
       Region 5x8q D 2347-2360 order
       Region 5x8q F 2347-2360 order
       Region 5x8q H 2346-2360 order
SeqProS possible 2346-2361 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. Hetero octamer : IID00031Complex
       Region 3r29 C 2346-2361 order
       Region 3r29 D 2349-2359 order
SeqProS possible 2347-2365 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. Hetero dimer : IID00382Complex
       Region 1kkq E 2347-2365 order
       Region 1kkq F 2347-2365 order
       Region 1kkq G 2347-2365 order
       Region 1kkq H 2347-2365 order
SeqProS possible 2349-2359 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. Hetero dimer : P06401
       Region 4oar B 2349-2359 order
SeqProS possible 2349-2360 This region may be ProS because of similarity to other nuclear receptor co-repressors/co-acitivators. Hetero nonamer : IID00057Complex
       Region 2gpv G 2349-2360 order
       Region 2gpv H 2349-2360 order
       Region 2gpv I 2349-2360 order
Seqphosphorylation
    54-54 Phosphoserine
    67-67 Phosphoserine
    149-149 Phosphoserine
    152-152 Phosphoserine
    156-156 Phosphothreonine
    215-215 Phosphoserine
    493-493 Phosphoserine
    553-553 Phosphothreonine
    554-554 Phosphoserine
    750-750 Phosphoserine
    753-753 Phosphoserine
    939-939 Phosphoserine
    946-946 Phosphothreonine
    956-956 Phosphoserine
    1181-1181 Phosphoserine
    1259-1259 Phosphoserine
    1331-1331 Phosphoserine
    1391-1391 Phosphothreonine
    1487-1487 Phosphoserine
    1547-1547 Phosphoserine
    1603-1603 Phosphoserine
    1627-1627 Phosphoserine
    1783-1783 Phosphoserine
    1786-1786 Phosphoserine
    1872-1872 Phosphoserine
    2016-2016 Phosphoserine
    2057-2057 Phosphoserine
    2065-2065 Phosphoserine
    2068-2068 Phosphoserine
    2069-2069 Phosphoserine
    2071-2071 Phosphoserine
    2073-2073 Phosphothreonine
    2088-2088 Phosphoserine
    2214-2214 Phosphoserine
    2234-2234 Phosphoserine
    2269-2269 Phosphoserine
    2424-2424 Phosphoserine
Seqacetylation
    878-878 N6-acetyllysine
    959-959 N6-acetyllysine
    1218-1218 N6-acetyllysine
    1248-1248 N6-acetyllysine
    1970-1970 N6-acetyllysine
    2037-2037 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-238,314-407,477-614,672-1421,1616-1629,1704-2525
Known Domain 408-476,615-671,1422-1615
Cryptic Domain 239-313,1630-1703
SCOPe RPS-Blast
     4a69C 408-476 2e-30 a.4.1.3 2610100b20rik gene product
     2ltpA 615-685 4e-27 a.4.1.0 automated matches
SCOP Hmmer
     1xc5A1 415-479 1.7e-18 a.4.1.3 2610100b20rik ge...
     1xc5A1 612-662 8.1e-16 a.4.1.3 2610100b20rik ge...
Pfam RPS-Blast
     PF15784 142-229 3e-21 G-protein pathway suppresso...
     PF05262 474-626 1e-05 Borrelia P83/100 protein
     PF00249 614-656 3e-07 Myb-like DNA-binding domain
     PF05110 667-1142 6e-05 AF-4 proto-oncoprotein
Pfam Hmmer
    PF15784 142-229 2.4e-42 G-protein pathway suppress...
    PF00249 613-657 6.3e-16 Myb-like DNA-binding domai...