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IID00114  E3 ubiquitin-protein ligase NEDD4-like (Homo sapiens) Q96PU5
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
975
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-154 Monomer :
 Evidence X-RAY 2nsq A Reference
       Region 2nsq A 1-5 disorder
       Region 2nsq A 6-35 order
       Region 2nsq A 36-39 disorder
       Region 2nsq A 40-120 order
       Region 2nsq A 121-125 disorder
       Region 2nsq A 126-154 order
Seq 385-417 Hetero dimer : IID00135Complex
 Evidence NMR 2lty A Reference
       Region 2lty A 385-417 order
Seq 386-420 Hetero dimer : IID00113Complex
 Evidence NMR 2lb2 A Reference
       Region 2lb2 A 386-420 order
Seq 496-535 Hetero dimer : IID00113Complex
 Evidence NMR 2laj A Reference
       Region 2laj A 496-535 order
Seq 496-539,945-957 Hetero dimer :
 Evidence NMR 2mpt A This complex is hetero dimer in the automatic decision, but is actually homo dimer. Reference
       Region 2mpt A 496-497 disorder
       Region 2mpt A 498-529 order
       Region 2mpt A 530-539 disorder
 Evidence NMR 2mpt B This complex is hetero dimer in the automatic decision, but is actually homo dimer. Reference
       Region 2mpt B 945-957 order
Seq 594-967 Homo dimer :
 Evidence X-RAY 2oni A Reference
       Region 2oni A 594-653 order
       Region 2oni A 654-654 disorder
       Region 2oni A 655-966 order
       Region 2oni A 967-967 disorder
Seq 594-975 Hetero dimer : P62987
 Evidence X-RAY 5hpk A Reference
       Region 5hpk A 594-653 order
       Region 5hpk A 654-658 disorder
       Region 5hpk A 659-969 order
       Region 5hpk A 970-975 disorder
Seq 596-975 Hetero trimer : P0CG48,P62837
 Evidence X-RAY 3jvz C Reference
       Region 3jvz C 596-970 order
       Region 3jvz C 971-975 disorder
 Evidence X-RAY 3jvz D Reference
       Region 3jvz D 596-969 order
       Region 3jvz D 970-975 disorder
 Evidence X-RAY 3jw0 C Reference
       Region 3jw0 C 596-970 order
       Region 3jw0 C 971-975 disorder
 Evidence X-RAY 3jw0 D Reference
       Region 3jw0 D 596-969 order
       Region 3jw0 D 970-975 disorder
Seqphosphorylation
    312-312 Phosphoserine
    318-318 Phosphothreonine
    342-342 Phosphoserine; by WNK1 and WNK4
    367-367 Phosphothreonine; by SGK1
    446-446 Phosphoserine
    448-448 Phosphoserine; by PKA and SGK1
    449-449 Phosphoserine; by WNK1 and WNK4
    464-464 Phosphoserine
    475-475 Phosphoserine
    479-479 Phosphoserine
    483-483 Phosphoserine
    487-487 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
DICHOT
Disorder 1-5,155-197,262-382,469-498,531-553,589-593,967-975
Known Domain 6-154,198-261,383-468,499-530,554-588,594-966
SCOPe RPS-Blast
     3b7yA 3-154 8e-58 b.7.1.0 automated matches
     2itkA1 195-225 3e-12 b.72.1.1 Amyloid beta A4 precursor protein-bin...
     2itkA1 387-416 3e-11 b.72.1.1 Amyloid beta A4 precursor protein-bin...
     1eg3A3 488-526 3e-07 b.72.1.1 Amyloid beta A4 precursor protein-bind...
     4n7fA1 498-530 2e-16 b.72.1.0 automated matches
     4rexA1 546-585 2e-13 b.72.1.1 Amyloid beta A4 precursor protein-bin...
     3h1dA1 596-966 0.0 d.148.1.0 automated matches
SCOP Hmmer
     2cjsA1 21-159 1.3e-33 b.7.1.1 Domain from cytos...
     2e45A1 185-227 8.7e-16 b.72.1.1 Amyloid beta A4...
     1i5hW_ 380-419 2.3e-15 b.72.1.1 Amyloid beta A4...
     1i5hW_ 498-532 7.1e-15 b.72.1.1 Amyloid beta A4...
     1i5hW_ 544-583 1.5e-15 b.72.1.1 Amyloid beta A4...
     1nd7A_ 601-968 1.7e-130 Hect, E3 ligase cataly...
Pfam RPS-Blast
     PF00397 195-224 4e-09 WW domain
     PF00397 387-416 7e-10 WW domain
     PF00397 499-528 7e-10 WW domain
     PF00397 550-579 2e-08 WW domain
     PF00632 670-972 1e-16 HECT-domain (ubiquitin-tran...
Pfam Hmmer
    PF00168 21-119 3.1e-29 C2 domain
    PF00397 195-224 1.1e-15 WW domain
    PF00397 387-416 1.3e-16 WW domain
    PF00397 499-528 1.5e-16 WW domain
    PF00397 550-579 1.3e-14 WW domain
    PF00632 670-972 1.7e-105 HECT-domain (ubiquitin-tr...