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IID00130  Retinoblastoma-like protein 1 (Homo sapiens) P28749
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
1068
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 391-599 Hetero dimer : Q5ZJQ3
 Evidence X-RAY 4yos A Reference
       Region 4yos A 391-593 order
       Region 4yos A 594-599 disorder
Seq 391-600,784-887,925-952,961-968 Hetero trimer : Q52LA3
 Evidence X-RAY 4yoo A Reference
       Region 4yoo A 391-593 order
       Region 4yoo A 594-600 disorder
       Region 4yoo A 784-885 order
       Region 4yoo A 886-887 disorder
       Region 4yoo A 925-952 order
       Region 4yoo A 961-968 order
Seq 391-593,777-972 Hetero trimer : P03129
 Evidence X-RAY 4yoz A Reference
       Region 4yoz A 391-593 order
       Region 4yoz A 777-779 disorder
       Region 4yoz A 780-885 order
       Region 4yoz A 886-887 disorder
       Region 4yoz A 888-923 order
       Region 4yoz A 924-925 disorder
       Region 4yoz A 926-949 order
       Region 4yoz A 950-961 disorder
       Region 4yoz A 962-967 order
       Region 4yoz A 968-972 disorder
Seq 653-663 Hetero trimer : IID00032Complex
 Evidence X-RAY 1h28 E Reference
       Region 1h28 E 653-653 disorder
       Region 1h28 E 654-663 order
 Evidence X-RAY 1h28 F Reference
       Region 1h28 F 653-655 disorder
       Region 1h28 F 656-663 order
Seq 994-1031 Hetero trimer : IID00076Complex,Q15329
 Evidence X-RAY 5tuv C Reference
       Region 5tuv C 994-999 disorder
       Region 5tuv C 1000-1028 order
       Region 5tuv C 1029-1031 disorder
 Evidence X-RAY 5tuv F Reference
       Region 5tuv F 994-1000 disorder
       Region 5tuv F 1001-1024 order
       Region 5tuv F 1025-1031 disorder
SeqProS possible 654-663 This region binds to CyclinA in the same surface to which p53, p27, E2F1, and Rb bind. Similar fragments of p53 and p27 are verified ProS. Hetero trimer : IID00032Complex
       Region 1h28 E 654-663 order
       Region 1h28 F 656-663 order
SeqProS predicted 1001-1024 The unbound state of this region is predicted to be disordered by DICHOT and Foldindex. Hetero trimer : IID00076Complex,Q15329
       Region 5tuv C 1000-1028 order
       Region 5tuv F 1001-1024 order
Seqphosphorylation
    332-332 Phosphothreonine; by CDK2
    369-369 Phosphothreonine; by CDK4
    385-385 Phosphothreonine; by CDK2
    640-640 Phosphoserine; by CDK2 and CDK4
    650-650 Phosphoserine
    749-749 Phosphoserine
    762-762 Phosphoserine; by CDK2
    964-964 Phosphoserine; by CDK2 and CDK4
    975-975 Phosphoserine; by CDK2 and CDK4
    988-988 Phosphoserine; by CDK2
    997-997 Phosphothreonine; by CDK2
    1009-1009 Phosphoserine; by CDK2
    1041-1041 Phosphoserine
 
Prediction
DICHOT
Disorder 1-19,337-390,594-781,969-1068
Known Domain 20-336,391-593,782-968
SCOPe RPS-Blast
     4yozA1 391-594 1e-77 a.74.1.0 automated matches
     4yozA2 780-967 2e-51 a.74.1.0 automated matches
SCOP Hmmer
     1aisB2 20-92 4.1e-05 a.74.1.2 Transcription fac...
     1guxA_ 393-580 2.5e-72 a.74.1.3 Retinoblastoma ...
     1guxB_ 787-968 4.5e-50 a.74.1.3 Retinoblastoma ...
Pfam RPS-Blast
     PF11934 80-209 1e-45 Domain of unknown function (...
     PF01858 385-578 5e-65 Retinoblastoma-associated p...
     PF01857 788-942 2e-38 Retinoblastoma-associated p...
     PF08934 949-1051 1e-30 Rb C-terminal domain
Pfam Hmmer
    PF11934 80-212 8.1e-54 Domain of unknown function ...
    PF01858 385-578 4.2e-82 Retinoblastoma-associated ...
    PF01857 787-943 1.8e-57 Retinoblastoma-associated ...
    PF08934 960-1046 3e-10 Rb C-terminal domain