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IID00137  Annexin A1 (Homo sapiens) P04083
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
346
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-12 Hetero dimer : IID50073Complex
 Evidence X-RAY 1qls D Reference
       Region 1qls D 2-12 order
Seq 2-26 Monomer :
 Evidence NMR 5vfw A Reference
       Region 5vfw A 2-26 order
       Region 5vfw A 2-3 high_rmsd
       Region 5vfw A 16-20 high_rmsd
       Region 5vfw A 25-26 high_rmsd
Seq 33-346 Monomer :
 Evidence X-RAY 1ain A Reference
       Region 1ain A 33-346 order
Seq 41-113 Monomer :
 Evidence NMR 1bo9 A Reference
       Region 1bo9 A 41-113 order
SeqProS possible 2-12 The N-terminal alpha helix seems to be necessary for binding to S100C. (PubMed=10673436) Hetero dimer : IID50073Complex
       Region 1qls D 2-12 order
Seqphosphorylation
    5-5 Phosphoserine; by TRPM7
    21-21 Phosphotyrosine; by EGFR
    27-27 Phosphoserine; by PKC
    34-34 Phosphoserine
    37-37 Phosphoserine
    41-41 Phosphothreonine
    136-136 Phosphothreonine
Seqacetylation
    2-2 N-acetylalanine
    58-58 N6-acetyllysine
    239-239 N6-acetyllysine
    312-312 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-1,345-346
Known Domain 2-344
SCOPe RPS-Blast
     1bo9A 42-113 2e-23 a.65.1.1 Annexin GH1
     1bo9A 116-185 3e-23 a.65.1.1 Annexin GH1
     1bo9A 199-269 1e-08 a.65.1.1 Annexin GH1
     1bo9A 279-343 3e-17 a.65.1.1 Annexin GH1
SCOP Hmmer
     1hm6A_ 8-344 4e-127 a.65.1.1 Annexin GH1
Pfam RPS-Blast
     PF00191 47-111 6e-08 Annexin
     PF00191 118-183 1e-15 Annexin
     PF00191 202-267 1e-06 Annexin
     PF00191 277-342 6e-14 Annexin
Pfam Hmmer
    PF00191 47-111 4.4e-24 Annexin
    PF00191 118-183 9.9e-30 Annexin
    PF00191 202-267 2.7e-24 Annexin
    PF00191 277-342 3.4e-28 Annexin