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IID00178  E3 ubiquitin-protein ligase Itchy homolog (Homo sapiens) Q96J02
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
903
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-155 Monomer :
 Evidence X-RAY 2nq3 A Reference
       Region 2nq3 A 1-12 disorder
       Region 2nq3 A 13-33 order
       Region 2nq3 A 34-35 disorder
       Region 2nq3 A 36-145 order
       Region 2nq3 A 146-155 disorder
Seq 246-270 Hetero dimer : O55043
 Evidence X-RAY 2p4r T Reference
       Region 2p4r T 246-249 disorder
       Region 2p4r T 250-265 order
       Region 2p4r T 266-270 disorder
Seq 249-269 Hetero trimer : IID00279Complex
 Evidence X-RAY 5sxp G Reference
       Region 5sxp G 249-268 order
       Region 5sxp G 269-269 disorder
 Evidence X-RAY 5sxp F Reference
       Region 5sxp F 249-250 disorder
       Region 5sxp F 251-269 order
Seq 328-357 Monomer :
 Evidence NMR 2dmv A Reference
       Region 2dmv A 328-357 order
Seq 359-392 Monomer :
 Evidence NMR 2kyk A Reference
       Region 2kyk A 359-392 order
       Region 2kyk A 391-392 high_rmsd
Seq 433-521 Hetero trimer : Q9H3M7
 Evidence X-RAY 5cq2 A Reference
       Region 5cq2 A 433-437 disorder
       Region 5cq2 A 438-472 order
       Region 5cq2 A 473-476 disorder
       Region 5cq2 A 477-517 order
       Region 5cq2 A 518-521 disorder
Seq 436-474 Hetero octamer : Q9H3M7
 Evidence X-RAY 5dws A Reference
       Region 5dws A 436-436 disorder
       Region 5dws A 437-473 order
       Region 5dws A 474-474 disorder
 Evidence X-RAY 5dws C Reference
       Region 5dws C 436-474 order
 Evidence X-RAY 5dws E Reference
       Region 5dws E 436-437 disorder
       Region 5dws E 438-472 order
       Region 5dws E 473-474 disorder
 Evidence X-RAY 5dws G Reference
       Region 5dws G 436-436 disorder
       Region 5dws G 437-473 order
       Region 5dws G 474-474 disorder
Seq 436-474 Hetero tetramer : Q9H3M7
 Evidence X-RAY 4rof A Reference
       Region 4rof A 436-436 disorder
       Region 4rof A 437-472 order
       Region 4rof A 473-474 disorder
 Evidence X-RAY 4rof B Reference
       Region 4rof B 436-436 disorder
       Region 4rof B 437-472 order
       Region 4rof B 473-474 disorder
Seq 475-514 Hetero tetramer : Q9H3M7
 Evidence X-RAY 5dzd A Reference
       Region 5dzd A 475-477 disorder
       Region 5dzd A 478-514 order
 Evidence X-RAY 5dzd B Reference
       Region 5dzd B 475-475 disorder
       Region 5dzd B 476-514 order
Seq 480-512 Monomer :
 Evidence NMR 2ysf A Reference
       Region 2ysf A 480-512 order
Seq 524-899 Hetero trimer : P0CG48
 Evidence X-RAY 5c7m A Reference
       Region 5c7m A 524-525 disorder
       Region 5c7m A 526-617 order
       Region 5c7m A 618-620 disorder
       Region 5c7m A 621-710 order
       Region 5c7m A 711-711 disorder
       Region 5c7m A 712-899 order
Seq 524-903 Monomer :
 Evidence X-RAY 3tug A Reference
       Region 3tug A 524-524 disorder
       Region 3tug A 525-615 order
       Region 3tug A 616-619 disorder
       Region 3tug A 620-695 order
       Region 3tug A 696-703 disorder
       Region 3tug A 704-706 order
       Region 3tug A 707-733 disorder
       Region 3tug A 734-897 order
       Region 3tug A 898-903 disorder
Seqphosphorylation
    240-240 Phosphoserine; by MAPK8
    263-263 Phosphothreonine; by MAPK8
    273-273 Phosphoserine; by MAPK8
    385-385 Phosphothreonine; by SGK3
    420-420 Phosphotyrosine; by FYN
    450-450 Phosphoserine; by SGK3
Seqacetylation
    2-2 N-acetylserine
 
Prediction
DICHOT
Disorder 1-12,146-318,400-437,518-524,898-903
Known Domain 13-145,319-399,438-517,525-897
SCOPe RPS-Blast
     2nq3A1 13-145 2e-40 b.7.1.1 Domain from cytosolic phospholipase A2
     4rexA1 327-357 2e-11 b.72.1.1 Amyloid beta A4 precursor protein-bin...
     4rexA1 354-389 1e-13 b.72.1.1 Amyloid beta A4 precursor protein-bin...
     4n7fA1 440-470 8e-15 b.72.1.0 automated matches
     4rexA1 466-515 1e-15 b.72.1.1 Amyloid beta A4 precursor protein-bin...
     3h1dA1 527-896 0.0 d.148.1.0 automated matches
SCOP Hmmer
     2nq3A1 17-139 2.7e-26 b.7.1.1 Domain from cytos...
     1i5hW_ 325-358 5e-14 b.72.1.1 Amyloid beta A4 p...
     2e45A1 358-392 2.7e-14 b.72.1.1 Amyloid beta A4...
     1i5hW_ 434-472 1.1e-16 b.72.1.1 Amyloid beta A4...
     1tk7A2 475-510 1.5e-13 b.72.1.1 Amyloid beta A4...
     1nd7A_ 530-897 8.3e-139 Hect, E3 ligase cataly...
Pfam RPS-Blast
     PF05297 182-323 1e-04 Herpesvirus latent membrane...
     PF00397 328-357 2e-09 WW domain
     PF00397 360-389 2e-09 WW domain
     PF00397 440-469 1e-11 WW domain
     PF00397 480-509 9e-06 WW domain
     PF00632 599-901 2e-19 HECT-domain (ubiquitin-tran...
Pfam Hmmer
    PF00168 19-109 2.6e-18 C2 domain
    PF00397 328-357 9.5e-15 WW domain
    PF00397 360-389 2.2e-15 WW domain
    PF00397 440-469 2.9e-18 WW domain
    PF00397 480-509 2.9e-10 WW domain
    PF00632 599-901 1e-101 HECT-domain (ubiquitin-tran...