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IID00199  Neurogenic locus notch homolog protein 1 (Homo sapiens) P46531
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
2555
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 140-294 Homo dimer :
 Evidence X-RAY 5fm9 A Reference
       Region 5fm9 A 140-140 disorder
       Region 5fm9 A 141-294 order
Seq 142-294 Monomer :
 Evidence X-RAY 5fma A Reference
       Region 5fma A 142-159 order
       Region 5fma A 160-160 disorder
       Region 5fma A 161-294 order
 Evidence X-RAY 5fma B Reference
       Region 5fma B 142-157 order
       Region 5fma B 158-160 disorder
       Region 5fma B 161-294 order
Seq 411-526 Homo dimer :
 Evidence X-RAY 4cud A Reference
       Region 4cud A 411-411 disorder
       Region 4cud A 412-526 order
 Evidence X-RAY 4cue A Reference
       Region 4cue A 411-411 disorder
       Region 4cue A 412-526 order
 Evidence X-RAY 4d0f A Reference
       Region 4d0f A 411-526 order
Seq 411-526 Monomer :
 Evidence X-RAY 4cuf A Reference
       Region 4cuf A 411-411 disorder
       Region 4cuf A 412-526 order
 Evidence X-RAY 4d0e A Reference
       Region 4d0e A 411-411 disorder
       Region 4d0e A 412-526 order
 Evidence X-RAY 2vj3 A Reference
       Region 2vj3 A 411-526 order
 Evidence NMR 1toz A Reference
       Region 1toz A 411-526 order
Seq 452-491 Hetero dimer : Q8NBL1
 Evidence X-RAY 5l0r B Reference
       Region 5l0r B 452-452 disorder
       Region 5l0r B 453-491 order
 Evidence X-RAY 5ub5 B Reference
       Region 5ub5 B 452-491 order
Seq 1446-1480 Monomer :
 Evidence NMR 1pb5 A Reference
       Region 1pb5 A 1446-1480 order
Seq 1446-1733 Hetero dimer :
 Evidence X-RAY 3i08 A Reference
       Region 3i08 A 1446-1447 disorder
       Region 3i08 A 1448-1621 order
       Region 3i08 A 1622-1664 disorder
 Evidence X-RAY 3i08 C Reference
       Region 3i08 C 1446-1447 disorder
       Region 3i08 C 1448-1621 order
       Region 3i08 C 1622-1664 disorder
 Evidence X-RAY 3i08 B Reference
       Region 3i08 B 1665-1668 disorder
       Region 3i08 B 1669-1728 order
       Region 3i08 B 1729-1733 disorder
 Evidence X-RAY 3i08 D Reference
       Region 3i08 D 1665-1670 disorder
       Region 3i08 D 1671-1728 order
       Region 3i08 D 1729-1733 disorder
Seq 1446-1733 Monomer :
 Evidence X-RAY 3eto A Reference
       Region 3eto A 1446-1447 disorder
       Region 3eto A 1448-1726 order
       Region 3eto A 1727-1733 disorder
 Evidence X-RAY 3eto B Reference
       Region 3eto B 1446-1447 disorder
       Region 3eto B 1448-1726 order
       Region 3eto B 1727-1733 disorder
Seq 1448-1728 Hetero pentamer :
 Evidence X-RAY 3l95 X Reference
       Region 3l95 X 1448-1686 order
       Region 3l95 X 1687-1689 disorder
       Region 3l95 X 1690-1726 order
       Region 3l95 X 1727-1728 disorder
 Evidence X-RAY 3l95 Y Reference
       Region 3l95 Y 1448-1459 disorder
       Region 3l95 Y 1460-1522 order
       Region 3l95 Y 1523-1525 disorder
       Region 3l95 Y 1526-1725 order
       Region 3l95 Y 1726-1728 disorder
Seq 1448-1728 Hetero tetramer :
 Evidence X-RAY 3l95 X Reference
       Region 3l95 X 1448-1686 order
       Region 3l95 X 1687-1689 disorder
       Region 3l95 X 1690-1726 order
       Region 3l95 X 1727-1728 disorder
 Evidence X-RAY 3l95 Y Reference
       Region 3l95 Y 1448-1459 disorder
       Region 3l95 Y 1460-1522 order
       Region 3l95 Y 1523-1525 disorder
       Region 3l95 Y 1526-1725 order
       Region 3l95 Y 1726-1728 disorder
Seq 1721-1771 Monomer :
 Evidence NMR 5kzo A Reference
       Region 5kzo A 1721-1771 order
       Region 5kzo A 1721-1727 high_rmsd
       Region 5kzo A 1761-1771 high_rmsd
Seq 1759-1777,1872-2126 Hetero tetramer : IID00220Complex,IID00380Complex
 Evidence X-RAY 3v79 K Reference
       Region 3v79 K 1872-1882 disorder
       Region 3v79 K 1883-1891 order
       Region 3v79 K 1892-1907 disorder
       Region 3v79 K 1908-1915 order
       Region 3v79 K 1916-1918 disorder
       Region 3v79 K 1919-2119 order
       Region 3v79 K 2120-2126 disorder
 Evidence X-RAY 3v79 R Reference
       Region 3v79 R 1759-1777 order
Seqdisorder 1761-1890
 Evidence CD Reference
       Region 1761-1890 disorder
Seq 1872-2114 Homo dimer :
 Evidence X-RAY 2he0 A Reference
       Region 2he0 A 1872-1920 disorder
       Region 2he0 A 1921-2114 order
 Evidence X-RAY 2he0 B Reference
       Region 2he0 B 1872-1922 disorder
       Region 2he0 B 1923-2114 order
Seq 1872-2126 Hetero hexamer : IID00220Complex,IID00380Complex
 Evidence X-RAY 3nbn B Reference
       Region 3nbn B 1872-1922 disorder
       Region 3nbn B 1923-2118 order
       Region 3nbn B 2119-2126 disorder
 Evidence X-RAY 3nbn E Reference
       Region 3nbn E 1872-1922 disorder
       Region 3nbn E 1923-2118 order
       Region 3nbn E 2119-2126 disorder
Seq 1872-2126 Hetero trimer : IID00220Complex,IID00380Complex
 Evidence X-RAY 2f8x K Reference
       Region 2f8x K 1872-1882 disorder
       Region 2f8x K 1883-1891 order
       Region 2f8x K 1892-1907 disorder
       Region 2f8x K 1908-1915 order
       Region 2f8x K 1916-1918 disorder
       Region 2f8x K 1919-2119 order
       Region 2f8x K 2120-2126 disorder
Seq 1872-2126 Monomer :
 Evidence X-RAY 2f8y A Reference
       Region 2f8y A 1905-1907 disorder
       Region 2f8y A 1908-2122 order
       Region 2f8y A 2123-2126 disorder
 Evidence X-RAY 2f8y B Reference
       Region 2f8y B 1905-1907 disorder
       Region 2f8y B 1908-2116 order
       Region 2f8y B 2117-2126 disorder
 Evidence X-RAY 1yyh A Reference
       Region 1yyh A 1872-1922 disorder
       Region 1yyh A 1923-2114 order
 Evidence X-RAY 1yyh B Reference
       Region 1yyh B 1872-1925 disorder
       Region 1yyh B 1926-2114 order
SeqProS verified 1759-1777 Hetero tetramer : IID00220Complex,IID00380Complex
       Region 3v79 R 1759-1777 order
       Region 1761-1890 disorder
Seqphosphorylation
    1861-1861 Phosphothreonine
 
Prediction
DICHOT
Disorder 1-23,530-552,839-843,1727-1734,1769-1872,2115-2555
Known Domain 24-529,553-838,844-1726,1873-2114
Cryptic Domain 1735-1768
SCOPe RPS-Blast
     1g1tA2 104-141 2e-04 g.3.11.1 Activated protein c (autoprothrombin I...
     1g1tA2 142-179 2e-05 g.3.11.1 Activated protein c (autoprothrombin I...
     5mwbA1 178-216 4e-06 g.3.11.0 automated matches
     1g1tA2 222-258 4e-05 g.3.11.1 Activated protein c (autoprothrombin I...
     1edmB 257-292 4e-07 g.3.11.1 Activated protein c (autoprothrombin II...
     5mwbA1 295-335 4e-08 g.3.11.0 automated matches
     1edmB 335-370 1e-05 g.3.11.1 Activated protein c (autoprothrombin II...
     5mwbA1 412-452 1e-10 g.3.11.0 automated matches
     1edmB 451-489 7e-11 g.3.11.1 Activated protein c (autoprothrombin II...
     1g1tA2 491-529 6e-09 g.3.11.1 Activated protein c (autoprothrombin I...
     1autL1 524-568 2e-09 g.3.11.1 Activated protein c (autoprothrombin I...
     1autL1 563-605 5e-10 g.3.11.1 Activated protein c (autoprothrombin I...
     1edmB 602-640 8e-10 g.3.11.1 Activated protein c (autoprothrombin II...
     1autL1 638-680 2e-09 g.3.11.1 Activated protein c (autoprothrombin I...
     1edmB 677-713 1e-10 g.3.11.1 Activated protein c (autoprothrombin II...
     1autL1 713-753 4e-10 g.3.11.1 Activated protein c (autoprothrombin I...
     1edmB 752-790 1e-10 g.3.11.1 Activated protein c (autoprothrombin II...
     1edmB 790-828 3e-10 g.3.11.1 Activated protein c (autoprothrombin II...
     1egfA 832-867 4e-04 g.3.11.1 Activated protein c (autoprothrombin II...
     5mwbA1 869-907 3e-09 g.3.11.0 automated matches
     1edmB 906-943 1e-08 g.3.11.1 Activated protein c (autoprothrombin II...
     1edmB 945-981 1e-11 g.3.11.1 Activated protein c (autoprothrombin II...
     1g1tA2 984-1022 2e-11 g.3.11.1 Activated protein c (autoprothrombin ...
     1edmB 1021-1057 4e-11 g.3.11.1 Activated protein c (autoprothrombin ...
     1edmB 1063-1096 2e-04 g.3.11.1 Activated protein c (autoprothrombin ...
     1edmB 1146-1180 2e-09 g.3.11.1 Activated protein c (autoprothrombin ...
     1edmB 1183-1220 2e-10 g.3.11.1 Activated protein c (autoprothrombin ...
     1edmB 1220-1265 3e-07 g.3.11.1 Activated protein c (autoprothrombin ...
     1edmB 1267-1305 4e-05 g.3.11.1 Activated protein c (autoprothrombin ...
     5mwbA1 1315-1348 4e-04 g.3.11.0 automated matches
     1pb5A 1446-1480 6e-07 g.65.1.1 Neurogenic locus notch homolog protei...
     2f8yA 1908-2122 4e-86 d.211.1.1 26S proteasome non-ATPase regulator...
SCOP Hmmer
     1haeA_ 25-58 8.8e-05 g.3.11.1 Activated protein...
     1haeA_ 60-100 1.2e-08 g.3.11.1 Activated protei...
     1haeA_ 104-140 1.6e-09 g.3.11.1 Activated prote...
     1haeA_ 141-185 9.2e-12 g.3.11.1 Activated prote...
     1tozA1 177-216 3.4e-10 g.3.11.1 Activated prote...
     1haeA_ 219-261 4.8e-10 g.3.11.1 Activated prote...
     1haeA_ 257-304 1.1e-11 g.3.11.1 Activated prote...
     2dtgE6 288-456 4.5e-14 g.3.9.1 EGF receptor Cys...
     2dtgE6 439-570 1e-16 g.3.9.1 EGF receptor Cys-r...
     2dtgE6 516-645 9e-14 g.3.9.1 EGF receptor Cys-r...
     2dtgE6 629-757 6.7e-14 g.3.9.1 EGF receptor Cys...
     1ffmA_ 754-796 1.4e-13 g.3.11.1 Activated prote...
     1ffmA_ 791-829 3e-12 g.3.11.1 Activated protein...
     1haeA_ 831-874 2.3e-11 g.3.11.1 Activated prote...
     2dtgE6 856-987 1.2e-13 g.3.9.1 EGF receptor Cys...
     2dtgE6 983-1101 4.2e-12 g.3.9.1 EGF receptor Cy...
     1haeA_ 1114-1146 4.3e-08 g.3.11.1 Activated pro...
     1ffmA_ 1146-1185 1.8e-11 g.3.11.1 Activated pro...
     2dtgE6 1170-1312 3.9e-15 g.3.9.1 EGF receptor C...
     1haeA_ 1308-1352 3.9e-09 g.3.11.1 Activated pro...
     1dvaL1 1345-1385 9.1e-08 g.3.11.1 Activated pro...
     1p9jA_ 1391-1428 3e-08 g.3.11.1 Activated prote...
     1pb5A_ 1448-1480 6.5e-08 g.65.1.1 Neurogenic lo...
     1pb5A_ 1489-1522 3.9e-09 g.65.1.1 Neurogenic lo...
     1pb5A_ 1529-1561 6.4e-09 g.65.1.1 Neurogenic lo...
     1s70B_ 1872-2116 8.4e-55 d.211.1.1 26S proteaso...
Pfam RPS-Blast
     PF00008 144-174 5e-04 EGF-like domain
     PF00008 456-486 2e-04 EGF-like domain
     PF00008 494-522 1e-04 EGF-like domain
     PF00008 532-562 5e-05 EGF-like domain
     PF00008 607-637 2e-04 EGF-like domain
     PF00008 682-712 5e-05 EGF-like domain
     PF00008 757-787 8e-05 EGF-like domain
     PF00008 795-825 4e-04 EGF-like domain
     PF00008 949-979 4e-04 EGF-like domain
     PF00008 987-1017 3e-04 EGF-like domain
     PF00008 1025-1055 3e-06 EGF-like domain
     PF00008 1063-1091 5e-04 EGF-like domain
     PF00008 1149-1179 2e-04 EGF-like domain
     PF00008 1187-1217 3e-05 EGF-like domain
     PF00066 1487-1521 4e-05 LNR domain
     PF00066 1532-1562 7e-04 LNR domain
     PF06816 1566-1621 3e-21 NOTCH protein
     PF07684 1672-1728 1e-15 NOTCH protein
     PF13857 1922-1966 2e-10 Ankyrin repeats (many cop...
     PF13857 1980-2033 2e-05 Ankyrin repeats (many cop...
     PF13857 2018-2068 1e-09 Ankyrin repeats (many cop...
     PF13857 2047-2101 6e-07 Ankyrin repeats (many cop...
     PF12938 2220-2440 2e-05 M domain of GW182
     PF11936 2480-2540 2e-21 Domain of unknown functio...
Pfam Hmmer
    PF00008 63-96 4.4e-08 EGF-like domain
    PF00008 106-136 1.3e-10 EGF-like domain
    PF00008 144-174 1.1e-08 EGF-like domain
    PF07645 178-213 7.3e-11 Calcium-binding EGF domain
    PF00008 222-252 9.9e-10 EGF-like domain
    PF00008 261-290 2.6e-09 EGF-like domain
    PF07645 295-329 1.4e-12 Calcium-binding EGF domain
    PF00008 339-367 6.6e-09 EGF-like domain
    PF07645 412-445 5.8e-14 Calcium-binding EGF domain
    PF00008 456-485 9.6e-10 EGF-like domain
    PF00008 494-522 2e-11 EGF-like domain
    PF00008 532-561 9.6e-12 EGF-like domain
    PF00008 570-598 1.3e-07 EGF-like domain
    PF00008 607-637 3.7e-08 EGF-like domain
    PF00008 645-673 7.5e-08 EGF-like domain
    PF00008 682-711 8.5e-10 EGF-like domain
    PF00008 720-748 4.8e-09 EGF-like domain
    PF00008 757-787 2.5e-08 EGF-like domain
    PF00008 795-824 6.3e-11 EGF-like domain
    PF00008 833-864 5.9e-08 EGF-like domain
    PF07645 869-902 2.2e-10 Calcium-binding EGF domain
    PF00008 911-939 3.8e-08 EGF-like domain
    PF12661 992-1013 8.4e-10 Human growth factor-like ...
    PF00008 1025-1055 2.8e-10 EGF-like domain
    PF00008 1063-1092 1.5e-10 EGF-like domain
    PF00008 1116-1141 5.6e-10 EGF-like domain
    PF00008 1149-1178 1.8e-10 EGF-like domain
    PF00008 1187-1215 1.3e-10 EGF-like domain
    PF00008 1236-1263 1.8e-10 EGF-like domain
    PF00008 1311-1343 4.1e-08 EGF-like domain
    PF12661 1357-1375 6.4e-06 Human growth factor-like...
    PF00066 1447-1480 2e-11 LNR domain
    PF00066 1487-1522 1.4e-15 LNR domain
    PF00066 1526-1561 4.7e-14 LNR domain
    PF06816 1566-1621 2.1e-28 NOTCH protein
    PF07684 1671-1728 4.5e-26 NOTCH protein
    PF00023 1880-1925 1.3e-07 Ankyrin repeat
    PF12796 1916-1989 7.2e-13 Ankyrin repeats (3 copie...
    PF12796 1999-2090 3.1e-14 Ankyrin repeats (3 copie...
    PF11936 2480-2539 9.3e-28 Domain of unknown functi...