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IID00237  Breast cancer type 2 susceptibility protein (Homo sapiens) P51587
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
3418
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 21-39 Hetero dimer : IID00249Complex
 Evidence X-RAY 3eu7 X Reference
       Region 3eu7 X 21-23 disorder
       Region 3eu7 X 24-37 order
       Region 3eu7 X 38-39 disorder
Seq 1517-1551 Hetero tetramer : IID00241Complex
 Evidence X-RAY 1n0w B Reference
       Region 1n0w B 1517-1518 disorder
       Region 1n0w B 1519-1551 order
SeqProS possible 1519-1551 This region is described to be disordered in the free state and be ordered when it binds eith RAD51. (PubMed=22971516) Hetero tetramer : IID00241Complex
       Region 1n0w B 1519-1551 order
Seqphosphorylation
    70-70 Phosphoserine
    445-445 Phosphoserine
    492-492 Phosphoserine
    755-755 Phosphoserine
    1970-1970 Phosphoserine
    2035-2035 Phosphothreonine
    2095-2095 Phosphoserine
    3291-3291 Phosphoserine; by CDK1 and CDK2
    3319-3319 Phosphoserine
    3387-3387 Phosphothreonine; by CHEK1 and CHEK2
 
Prediction
DICHOT
Disorder 1-59,100-131,172-202,246-395,442-481,515-553,600-799,852-899,960-989,1050-1211,1248-1518,1589-2171,2209-2478,3185-3265,3296-3418
Known Domain 1519-1551,2479-3184
Cryptic Domain 60-99,132-171,203-245,396-441,482-514,554-599,800-851,900-959,990-1049,1212-1247,1552-1588,2172-2208,3266-3295
SCOPe RPS-Blast
     1iyjB1 2479-2667 6e-76 a.170.1.1 BRCA2 helical domain
     1iyjB3 2669-2801 1e-46 b.40.4.3 Archaeal ssDNA-binding protein
     1iyjB2 2831-2968 9e-41 a.171.1.1 BRCA2 tower domain
     1iyjB4 2951-3051 8e-32 b.40.4.3 Archaeal ssDNA-binding protein
     1iyjB5 3052-3190 2e-48 b.40.4.3 Archaeal ssDNA-binding protein
SCOP Hmmer
     1miuA1 2479-2668 8.1e-90 a.170.1.1 BRCA2 helica...
     1miuA3 2669-2801 1.5e-49 b.40.4.3 Archaeal ssDN...
     1miuA2 2831-2967 1.6e-59 a.171.1.1 BRCA2 tower ...
     1miuA5 3052-3184 4.7e-57 b.40.4.3 Archaeal ssDN...
Pfam RPS-Blast
     PF09169 2482-2666 9e-64 BRCA2, helical
     PF09103 2670-2794 1e-34 BRCA2, oligonucleotide/ol...
     PF09121 2831-2872 5e-13 Tower
     PF09104 3052-3185 2e-48 BRCA2, oligonucleotide/ol...
Pfam Hmmer
    PF00634 1004-1035 8.4e-13 BRCA2 repeat
    PF00634 1213-1245 3.6e-15 BRCA2 repeat
    PF00634 1422-1453 1e-12 BRCA2 repeat
    PF00634 1518-1550 2.8e-15 BRCA2 repeat
    PF00634 1665-1695 5.5e-13 BRCA2 repeat
    PF00634 1840-1868 6.6e-08 BRCA2 repeat
    PF00634 1973-2004 8.4e-14 BRCA2 repeat
    PF00634 2053-2083 3.2e-10 BRCA2 repeat
    PF09169 2482-2667 2.2e-98 BRCA2, helical
    PF09103 2670-2794 1.1e-44 BRCA2, oligonucleotide/o...
    PF09121 2831-2872 4.8e-23 Tower
    PF09104 3052-3185 4.7e-56 BRCA2, oligonucleotide/o...