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IID00247  Splicing factor 1 (Homo sapiens) Q15637
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
639
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-25
 Evidence NMR Reference
       Region 1-25 disorder
Seq 1-145 Hetero dimer : IID00147Complex
 Evidence X-RAY 4fxw B Reference
       Region 4fxw B 14-19 disorder
       Region 4fxw B 20-25 order
       Region 4fxw B 26-33 disorder
       Region 4fxw B 34-128 order
       Region 4fxw B 129-132 disorder
 Evidence X-RAY 4fxw D Reference
       Region 4fxw D 14-18 disorder
       Region 4fxw D 19-25 order
       Region 4fxw D 26-31 disorder
       Region 4fxw D 32-126 order
       Region 4fxw D 127-127 disorder
       Region 4fxw D 128-132 order
 Evidence NMR 2m0g A Reference
       Region 2m0g A 1-145 order
       Region 2m0g A 1-10 high_rmsd
       Region 2m0g A 27-35 high_rmsd
       Region 2m0g A 71-97 high_rmsd
       Region 2m0g A 133-145 high_rmsd
Seq 13-25 Hetero dimer : IID00147Complex
 Evidence NMR 1o0p B Reference
       Region 1o0p B 13-25 order
 Evidence NMR 1opi B Reference
       Region 1opi B 13-25 order
Seq 26-145 Monomer :
 Evidence X-RAY 4fxx A Reference
       Region 4fxx A 26-32 disorder
       Region 4fxx A 33-74 order
       Region 4fxx A 75-80 disorder
       Region 4fxx A 81-131 order
       Region 4fxx A 132-132 disorder
 Evidence X-RAY 4fxx B Reference
       Region 4fxx B 26-35 disorder
       Region 4fxx B 36-72 order
       Region 4fxx B 73-82 disorder
       Region 4fxx B 83-131 order
       Region 4fxx B 132-132 disorder
 Evidence X-RAY 4fxx C Reference
       Region 4fxx C 26-32 disorder
       Region 4fxx C 33-73 order
       Region 4fxx C 74-81 disorder
       Region 4fxx C 82-131 order
       Region 4fxx C 132-132 disorder
 Evidence X-RAY 4fxx D Reference
       Region 4fxx D 26-72 order
       Region 4fxx D 73-83 disorder
       Region 4fxx D 84-90 order
       Region 4fxx D 91-92 disorder
       Region 4fxx D 93-132 order
 Evidence NMR 2m09 A Reference
       Region 2m09 A 27-145 order
       Region 2m09 A 27-36 high_rmsd
       Region 2m09 A 75-83 high_rmsd
       Region 2m09 A 89-91 high_rmsd
       Region 2m09 A 134-145 high_rmsd
Seq 133-260 Monomer :
 Evidence NMR 1k1g A Reference
       Region 1k1g A 133-133 disorder
       Region 1k1g A 134-255 order
       Region 1k1g A 191-192 high_rmsd
       Region 1k1g A 256-260 disorder
SeqProS verified 13-25 Hetero dimer : IID00147Complex
       Region 1opi B 13-25 order
       Region 1o0p B 13-25 order
       Region 1-25 disorder
Seqphosphorylation
    14-14 Phosphoserine
    20-20 Phosphoserine; by PKG
    80-80 Phosphoserine
    82-82 Phosphoserine
    87-87 Phosphotyrosine
    89-89 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
DICHOT
Disorder 1-26,256-273,297-639
Known Domain 27-255,274-296
SCOPe RPS-Blast
     1k1gA 134-255 2e-37 d.51.1.1 Exosome complex RNA-binding protein 1, ...
SCOP Hmmer
     1k1gA_ 135-254 1.5e-28 d.51.1.1 Exosome complex...
Pfam RPS-Blast
     PF16275 18-130 4e-32 Splicing factor 1 helix-hair...
     PF15782 331-530 3e-06 Gene regulated by oestrogen...
     PF04625 504-636 1e-05 DEC-1 protein, N-terminal r...
Pfam Hmmer
    PF16275 19-130 1.3e-47 Splicing factor 1 helix-hai...
    PF00013 140-223 6.4e-11 KH domain
    PF00098 278-293 3.7e-08 Zinc knuckle