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IID00276  Activated CDC42 kinase 1 (Homo sapiens) Q07912
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
1038
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 109-453 Monomer :
 Evidence X-RAY 3eqp B Reference
       Region 3eqp B 117-160 order
       Region 3eqp B 161-166 disorder
       Region 3eqp B 167-392 order
 Evidence X-RAY 3eqp A Reference
       Region 3eqp A 117-160 order
       Region 3eqp A 161-166 disorder
       Region 3eqp A 167-390 order
       Region 3eqp A 391-392 disorder
 Evidence X-RAY 3eqr A Reference
       Region 3eqr A 117-161 order
       Region 3eqr A 162-167 disorder
       Region 3eqr A 168-392 order
 Evidence X-RAY 3eqr B Reference
       Region 3eqr B 117-286 order
       Region 3eqr B 287-289 disorder
       Region 3eqr B 290-390 order
       Region 3eqr B 391-392 disorder
 Evidence X-RAY 4hzr A Reference
       Region 4hzr A 115-116 disorder
       Region 4hzr A 117-134 order
       Region 4hzr A 135-137 disorder
       Region 4hzr A 138-160 order
       Region 4hzr A 161-169 disorder
       Region 4hzr A 170-389 order
 Evidence X-RAY 4hzr B Reference
       Region 4hzr B 115-117 disorder
       Region 4hzr B 118-133 order
       Region 4hzr B 134-138 disorder
       Region 4hzr B 139-159 order
       Region 4hzr B 160-168 disorder
       Region 4hzr B 169-389 order
 Evidence X-RAY 4hzs A Reference
       Region 4hzs A 115-278 order
       Region 4hzs A 279-291 disorder
       Region 4hzs A 292-446 order
       Region 4hzs A 447-453 disorder
 Evidence X-RAY 4hzs B Reference
       Region 4hzs B 115-278 order
       Region 4hzs B 279-291 disorder
       Region 4hzs B 292-446 order
       Region 4hzs B 447-453 disorder
 Evidence X-RAY 4hzs C Reference
       Region 4hzs C 115-278 order
       Region 4hzs C 279-291 disorder
       Region 4hzs C 292-446 order
       Region 4hzs C 447-453 disorder
 Evidence X-RAY 4hzs D Reference
       Region 4hzs D 115-278 order
       Region 4hzs D 279-291 disorder
       Region 4hzs D 292-446 order
       Region 4hzs D 447-453 disorder
 Evidence X-RAY 1u46 A Reference
       Region 1u46 A 109-116 disorder
       Region 1u46 A 117-133 order
       Region 1u46 A 134-137 disorder
       Region 1u46 A 138-159 order
       Region 1u46 A 160-167 disorder
       Region 1u46 A 168-279 order
       Region 1u46 A 280-280 disorder
       Region 1u46 A 281-286 order
       Region 1u46 A 287-291 disorder
       Region 1u46 A 292-389 order
       Region 1u46 A 390-395 disorder
 Evidence X-RAY 1u46 B Reference
       Region 1u46 B 109-116 disorder
       Region 1u46 B 117-133 order
       Region 1u46 B 134-137 disorder
       Region 1u46 B 138-159 order
       Region 1u46 B 160-170 disorder
       Region 1u46 B 171-222 order
       Region 1u46 B 223-224 disorder
       Region 1u46 B 225-390 order
       Region 1u46 B 391-395 disorder
 Evidence X-RAY 1u4d A Reference
       Region 1u4d A 109-116 disorder
       Region 1u4d A 117-159 order
       Region 1u4d A 160-167 disorder
       Region 1u4d A 168-279 order
       Region 1u4d A 280-281 disorder
       Region 1u4d A 282-286 order
       Region 1u4d A 287-291 disorder
       Region 1u4d A 292-389 order
       Region 1u4d A 390-395 disorder
 Evidence X-RAY 1u4d B Reference
       Region 1u4d B 109-116 disorder
       Region 1u4d B 117-160 order
       Region 1u4d B 161-169 disorder
       Region 1u4d B 170-221 order
       Region 1u4d B 222-224 disorder
       Region 1u4d B 225-390 order
       Region 1u4d B 391-395 disorder
 Evidence X-RAY 1u54 A Reference
       Region 1u54 A 109-114 disorder
       Region 1u54 A 115-134 order
       Region 1u54 A 135-137 disorder
       Region 1u54 A 138-160 order
       Region 1u54 A 161-169 disorder
       Region 1u54 A 170-290 order
       Region 1u54 A 291-291 disorder
       Region 1u54 A 292-390 order
       Region 1u54 A 391-395 disorder
 Evidence X-RAY 1u54 B Reference
       Region 1u54 B 109-116 disorder
       Region 1u54 B 117-134 order
       Region 1u54 B 135-137 disorder
       Region 1u54 B 138-160 order
       Region 1u54 B 161-168 disorder
       Region 1u54 B 169-388 order
       Region 1u54 B 389-395 disorder
Seq 117-391 Homo dimer :
 Evidence X-RAY 4ewh A Reference
       Region 4ewh A 117-391 order
 Evidence X-RAY 4ewh B Reference
       Region 4ewh B 117-390 order
       Region 4ewh B 391-391 disorder
 Evidence X-RAY 4id7 A Reference
       Region 4id7 A 117-162 order
       Region 4id7 A 163-167 disorder
       Region 4id7 A 168-389 order
Seqdisorder 448-489
 Evidence NMR Reference
       Region 448-489 disorder
Seq 448-489 Hetero dimer : IID00308Complex
 Evidence NMR 1cf4 B Reference
       Region 1cf4 B 448-489 order
SeqProS verified 448-489 Hetero dimer : IID00308Complex
       Region 1cf4 B 448-489 order
       Region 448-489 disorder
Seqphosphorylation
    284-284 Phosphotyrosine; by SRC and autocatalysis
    518-518 Phosphotyrosine
    724-724 Phosphoserine
    827-827 Phosphotyrosine
    859-859 Phosphotyrosine
    872-872 Phosphotyrosine
    881-881 Phosphoserine
 
Prediction
DICHOT
Disorder 1-116,390-392,478-960,1031-1038
Known Domain 117-389,393-477,961-1030
SCOPe RPS-Blast
     4hzrA 117-389 e-145 d.144.1.7 3-phosphoinositide dependent protein ...
     1gcqC1 376-443 3e-12 b.34.2.1 53BP2
SCOP Hmmer
     1m14A_ 120-398 1.8e-76 d.144.1.7 3-phosphoinosi...
     1k1zA_ 387-444 8.5e-11 b.34.2.1 53BP2
     1wj7A1 961-993 0.00015 a.5.2.1 4931431F19Rik
Pfam RPS-Blast
     PF07714 127-385 8e-07 Protein tyrosine kinase
     PF14604 395-439 3e-05 Variant SH3 domain
     PF09027 447-514 4e-21 GTPase binding
     PF15782 591-804 2e-04 Gene regulated by oestrogen...
     PF11555 775-839 2e-12 EGFR receptor inhibitor Mig...
     PF16678 970-1030 2e-04 HOIP UBA domain pair
Pfam Hmmer
    PF07714 126-385 3.2e-90 Protein tyrosine kinase
    PF14604 395-444 2.8e-14 Variant SH3 domain
    PF09027 447-514 7.5e-48 GTPase binding
    PF11555 774-839 7e-29 EGFR receptor inhibitor Mig-...