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IID00277  Serine/threonine-protein kinase PAK 1 (Homo sapiens) Q13153
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
545
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 70-149,249-545 Hetero tetramer :
 Evidence X-RAY 1f3m A Reference
       Region 1f3m A 70-77 disorder
       Region 1f3m A 78-147 order
       Region 1f3m A 148-149 disorder
 Evidence X-RAY 1f3m B Reference
       Region 1f3m B 70-77 disorder
       Region 1f3m B 78-147 order
       Region 1f3m B 148-149 disorder
 Evidence X-RAY 1f3m C Reference
       Region 1f3m C 249-415 order
       Region 1f3m C 416-422 disorder
       Region 1f3m C 423-542 order
       Region 1f3m C 543-545 disorder
 Evidence X-RAY 1f3m D Reference
       Region 1f3m D 249-416 order
       Region 1f3m D 417-425 disorder
       Region 1f3m D 426-542 order
       Region 1f3m D 543-545 disorder
Seq 74-109 Hetero dimer : P60763
 Evidence X-RAY 2qme I Reference
       Region 2qme I 74-97 order
       Region 2qme I 98-109 disorder
Seq 183-204 Hetero dimer : IID00279Complex
 Evidence NMR 1zsg B Reference
       Region 1zsg B 183-204 order
Seq 212-221 Hetero tetramer : IID50051Complex
 Evidence X-RAY 3dvp C Reference
       Region 3dvp C 212-212 disorder
       Region 3dvp C 213-221 order
 Evidence X-RAY 3dvp D Reference
       Region 3dvp D 212-212 disorder
       Region 3dvp D 213-221 order
Seq 248-545 Monomer :
 Evidence X-RAY 6b16 A Reference
       Region 6b16 A 249-250 disorder
       Region 6b16 A 251-300 order
       Region 6b16 A 301-305 disorder
       Region 6b16 A 306-335 order
       Region 6b16 A 336-337 disorder
       Region 6b16 A 338-542 order
       Region 6b16 A 543-545 disorder
 Evidence X-RAY 6b16 B Reference
       Region 6b16 B 249-254 disorder
       Region 6b16 B 255-409 order
       Region 6b16 B 410-416 disorder
       Region 6b16 B 417-542 order
       Region 6b16 B 543-545 disorder
 Evidence X-RAY 4daw A Reference
       Region 4daw A 249-542 order
       Region 4daw A 543-545 disorder
 Evidence X-RAY 5dew A Reference
       Region 5dew A 249-249 disorder
       Region 5dew A 250-544 order
       Region 5dew A 545-545 disorder
 Evidence X-RAY 5dew B Reference
       Region 5dew B 249-254 disorder
       Region 5dew B 255-410 order
       Region 5dew B 411-417 disorder
       Region 5dew B 418-542 order
       Region 5dew B 543-545 disorder
 Evidence X-RAY 5dey A Reference
       Region 5dey A 249-249 disorder
       Region 5dey A 250-544 order
       Region 5dey A 545-545 disorder
 Evidence X-RAY 5dey B Reference
       Region 5dey B 249-254 disorder
       Region 5dey B 255-410 order
       Region 5dey B 411-417 disorder
       Region 5dey B 418-542 order
       Region 5dey B 543-545 disorder
 Evidence X-RAY 5dfp A Reference
       Region 5dfp A 249-541 order
       Region 5dfp A 542-545 disorder
 Evidence X-RAY 4eqc A Reference
       Region 4eqc A 249-541 order
       Region 4eqc A 542-545 disorder
 Evidence X-RAY 3fxz A Reference
       Region 3fxz A 249-541 order
       Region 3fxz A 542-545 disorder
 Evidence X-RAY 3fy0 A Reference
       Region 3fy0 A 249-541 order
       Region 3fy0 A 542-545 disorder
 Evidence X-RAY 2hy8 1 Reference
       Region 2hy8 1 249-541 order
       Region 2hy8 1 542-545 disorder
 Evidence X-RAY 5ime A Reference
       Region 5ime A 249-250 disorder
       Region 5ime A 251-267 order
       Region 5ime A 268-274 disorder
       Region 5ime A 275-289 order
       Region 5ime A 290-293 disorder
       Region 5ime A 294-303 order
       Region 5ime A 304-308 disorder
       Region 5ime A 309-545 order
 Evidence X-RAY 5ime B Reference
       Region 5ime B 249-249 disorder
       Region 5ime B 250-302 order
       Region 5ime B 303-306 disorder
       Region 5ime B 307-408 order
       Region 5ime B 409-416 disorder
       Region 5ime B 417-541 order
       Region 5ime B 542-545 disorder
 Evidence X-RAY 5kbq A Reference
       Region 5kbq A 254-542 order
 Evidence X-RAY 5kbq B Reference
       Region 5kbq B 254-254 disorder
       Region 5kbq B 255-277 order
       Region 5kbq B 278-281 disorder
       Region 5kbq B 282-407 order
       Region 5kbq B 408-418 disorder
       Region 5kbq B 419-542 order
 Evidence X-RAY 5kbr A Reference
       Region 5kbr A 254-254 disorder
       Region 5kbr A 255-287 order
       Region 5kbr A 288-294 disorder
       Region 5kbr A 295-300 order
       Region 5kbr A 301-309 disorder
       Region 5kbr A 310-334 order
       Region 5kbr A 335-340 disorder
       Region 5kbr A 341-412 order
       Region 5kbr A 413-419 disorder
       Region 5kbr A 420-542 order
 Evidence X-RAY 5kbr B Reference
       Region 5kbr B 254-254 disorder
       Region 5kbr B 255-277 order
       Region 5kbr B 278-282 disorder
       Region 5kbr B 283-301 order
       Region 5kbr B 302-313 disorder
       Region 5kbr B 314-407 order
       Region 5kbr B 408-418 disorder
       Region 5kbr B 419-542 order
 Evidence X-RAY 4o0r A Reference
       Region 4o0r A 249-541 order
       Region 4o0r A 542-545 disorder
 Evidence X-RAY 4o0r B Reference
       Region 4o0r B 249-304 order
       Region 4o0r B 305-308 disorder
       Region 4o0r B 309-409 order
       Region 4o0r B 410-417 disorder
       Region 4o0r B 418-542 order
       Region 4o0r B 543-545 disorder
 Evidence X-RAY 4o0t A Reference
       Region 4o0t A 249-250 disorder
       Region 4o0t A 251-542 order
       Region 4o0t A 543-545 disorder
 Evidence X-RAY 4o0t B Reference
       Region 4o0t B 249-254 disorder
       Region 4o0t B 255-408 order
       Region 4o0t B 409-416 disorder
       Region 4o0t B 417-542 order
       Region 4o0t B 543-545 disorder
 Evidence X-RAY 4p90 A Reference
       Region 4p90 A 249-249 disorder
       Region 4p90 A 250-288 order
       Region 4p90 A 289-294 disorder
       Region 4p90 A 295-301 order
       Region 4p90 A 302-308 disorder
       Region 4p90 A 309-335 order
       Region 4p90 A 336-338 disorder
       Region 4p90 A 339-414 order
       Region 4p90 A 415-419 disorder
       Region 4p90 A 420-542 order
       Region 4p90 A 543-545 disorder
 Evidence X-RAY 4p90 B Reference
       Region 4p90 B 249-256 disorder
       Region 4p90 B 257-277 order
       Region 4p90 B 278-281 disorder
       Region 4p90 B 282-303 order
       Region 4p90 B 304-312 disorder
       Region 4p90 B 313-407 order
       Region 4p90 B 408-418 disorder
       Region 4p90 B 419-542 order
       Region 4p90 B 543-545 disorder
 Evidence X-RAY 3q52 A Reference
       Region 3q52 A 248-249 disorder
       Region 3q52 A 250-542 order
       Region 3q52 A 543-545 disorder
 Evidence X-RAY 3q53 A Reference
       Region 3q53 A 248-249 disorder
       Region 3q53 A 250-541 order
       Region 3q53 A 542-545 disorder
 Evidence X-RAY 1yhv A Reference
       Region 1yhv A 249-541 order
       Region 1yhv A 542-545 disorder
 Evidence X-RAY 1yhw A Reference
       Region 1yhw A 249-541 order
       Region 1yhw A 542-545 disorder
 Evidence X-RAY 4zji A Reference
       Region 4zji A 249-253 disorder
       Region 4zji A 254-303 order
       Region 4zji A 304-308 disorder
       Region 4zji A 309-416 order
       Region 4zji A 417-422 disorder
       Region 4zji A 423-542 order
       Region 4zji A 543-545 disorder
 Evidence X-RAY 4zji B Reference
       Region 4zji B 249-253 disorder
       Region 4zji B 254-304 order
       Region 4zji B 305-309 disorder
       Region 4zji B 310-416 order
       Region 4zji B 417-422 disorder
       Region 4zji B 423-540 order
       Region 4zji B 541-545 disorder
 Evidence X-RAY 4zji C Reference
       Region 4zji C 249-249 disorder
       Region 4zji C 250-289 order
       Region 4zji C 290-290 disorder
       Region 4zji C 291-302 order
       Region 4zji C 303-307 disorder
       Region 4zji C 308-413 order
       Region 4zji C 414-418 disorder
       Region 4zji C 419-541 order
       Region 4zji C 542-545 disorder
 Evidence X-RAY 4zji D Reference
       Region 4zji D 249-252 disorder
       Region 4zji D 253-302 order
       Region 4zji D 303-307 disorder
       Region 4zji D 308-410 order
       Region 4zji D 411-411 disorder
       Region 4zji D 412-415 order
       Region 4zji D 416-418 disorder
       Region 4zji D 419-541 order
       Region 4zji D 542-545 disorder
 Evidence X-RAY 4zjj A Reference
       Region 4zjj A 249-304 order
       Region 4zjj A 305-308 disorder
       Region 4zjj A 309-415 order
       Region 4zjj A 416-422 disorder
       Region 4zjj A 423-539 order
       Region 4zjj A 540-545 disorder
 Evidence X-RAY 4zjj B Reference
       Region 4zjj B 249-250 disorder
       Region 4zjj B 251-303 order
       Region 4zjj B 304-308 disorder
       Region 4zjj B 309-415 order
       Region 4zjj B 416-422 disorder
       Region 4zjj B 423-539 order
       Region 4zjj B 540-545 disorder
 Evidence X-RAY 4zjj C Reference
       Region 4zjj C 249-250 disorder
       Region 4zjj C 251-291 order
       Region 4zjj C 292-293 disorder
       Region 4zjj C 294-304 order
       Region 4zjj C 305-307 disorder
       Region 4zjj C 308-336 order
       Region 4zjj C 337-338 disorder
       Region 4zjj C 339-409 order
       Region 4zjj C 410-416 disorder
       Region 4zjj C 417-437 order
       Region 4zjj C 438-439 disorder
       Region 4zjj C 440-542 order
       Region 4zjj C 543-545 disorder
 Evidence X-RAY 4zjj D Reference
       Region 4zjj D 249-251 disorder
       Region 4zjj D 252-263 order
       Region 4zjj D 264-266 disorder
       Region 4zjj D 267-290 order
       Region 4zjj D 291-294 disorder
       Region 4zjj D 295-303 order
       Region 4zjj D 304-306 disorder
       Region 4zjj D 307-334 order
       Region 4zjj D 335-336 disorder
       Region 4zjj D 337-411 order
       Region 4zjj D 412-415 disorder
       Region 4zjj D 416-541 order
       Region 4zjj D 542-545 disorder
 Evidence X-RAY 4zy4 A Reference
       Region 4zy4 A 249-300 order
       Region 4zy4 A 301-305 disorder
       Region 4zy4 A 306-541 order
       Region 4zy4 A 542-545 disorder
 Evidence X-RAY 4zy4 B Reference
       Region 4zy4 B 249-305 order
       Region 4zy4 B 306-306 disorder
       Region 4zy4 B 307-541 order
       Region 4zy4 B 542-545 disorder
 Evidence X-RAY 4zy5 A Reference
       Region 4zy5 A 249-250 disorder
       Region 4zy5 A 251-273 order
       Region 4zy5 A 274-274 disorder
       Region 4zy5 A 275-300 order
       Region 4zy5 A 301-305 disorder
       Region 4zy5 A 306-335 order
       Region 4zy5 A 336-338 disorder
       Region 4zy5 A 339-542 order
       Region 4zy5 A 543-545 disorder
 Evidence X-RAY 4zy5 B Reference
       Region 4zy5 B 249-254 disorder
       Region 4zy5 B 255-304 order
       Region 4zy5 B 305-305 disorder
       Region 4zy5 B 306-542 order
       Region 4zy5 B 543-545 disorder
 Evidence X-RAY 4zy6 A Reference
       Region 4zy6 A 249-250 disorder
       Region 4zy6 A 251-300 order
       Region 4zy6 A 301-306 disorder
       Region 4zy6 A 307-336 order
       Region 4zy6 A 337-338 disorder
       Region 4zy6 A 339-542 order
       Region 4zy6 A 543-545 disorder
 Evidence X-RAY 4zy6 B Reference
       Region 4zy6 B 249-254 disorder
       Region 4zy6 B 255-410 order
       Region 4zy6 B 411-418 disorder
       Region 4zy6 B 419-542 order
       Region 4zy6 B 543-545 disorder
Seq 248-545 Homo dimer :
 Evidence X-RAY 3q4z A Reference
       Region 3q4z A 248-250 disorder
       Region 3q4z A 251-267 order
       Region 3q4z A 268-272 disorder
       Region 3q4z A 273-289 order
       Region 3q4z A 290-293 disorder
       Region 3q4z A 294-303 order
       Region 3q4z A 304-308 disorder
       Region 3q4z A 309-545 order
 Evidence X-RAY 3q4z B Reference
       Region 3q4z B 248-249 disorder
       Region 3q4z B 250-302 order
       Region 3q4z B 303-306 disorder
       Region 3q4z B 307-408 order
       Region 3q4z B 409-417 disorder
       Region 3q4z B 418-541 order
       Region 3q4z B 542-545 disorder
 Evidence X-RAY 4zlo A Reference
       Region 4zlo A 249-249 disorder
       Region 4zlo A 250-278 order
       Region 4zlo A 279-280 disorder
       Region 4zlo A 281-302 order
       Region 4zlo A 303-307 disorder
       Region 4zlo A 308-409 order
       Region 4zlo A 410-418 disorder
       Region 4zlo A 419-543 order
       Region 4zlo A 544-545 disorder
 Evidence X-RAY 4zlo B Reference
       Region 4zlo B 249-252 disorder
       Region 4zlo B 253-263 order
       Region 4zlo B 264-266 disorder
       Region 4zlo B 267-278 order
       Region 4zlo B 279-283 disorder
       Region 4zlo B 284-288 order
       Region 4zlo B 289-292 disorder
       Region 4zlo B 293-301 order
       Region 4zlo B 302-309 disorder
       Region 4zlo B 310-334 order
       Region 4zlo B 335-341 disorder
       Region 4zlo B 342-543 order
       Region 4zlo B 544-545 disorder
SeqProS possible 183-204 This region is described to be disordered in the free state. (PubMed=18650427) Hetero dimer : IID00279Complex
       Region 1zsg B 183-204 order
SeqProS possible 213-221 This region is described to be disordered in the free state. (PubMed=18650427) Hetero tetramer : IID50051Complex
       Region 3dvp C 213-221 order
       Region 3dvp D 213-221 order
SeqProS verified 417-425 This region is ordered in the Thr-423 phosphorylated but disordered in the autoinhibit conformation. :
       Region 3fy0 A 249-541 order
       Region 3fxz A 249-541 order
       Region 3q52 A 250-542 order
       Region 4daw A 249-542 order
       Region 3q53 A 250-541 order
       Region 4eqc A 249-541 order
       Region 1f3m D 417-425 disorder
Seqphosphorylation
    21-21 Phosphoserine; by PKB and autocatalysis
    57-57 Phosphoserine; by autocatalysis
    84-84 Phosphothreonine; by OXSR1
    115-115 Phosphoserine
    131-131 Phosphotyrosine
    142-142 Phosphotyrosine
    144-144 Phosphoserine
    149-149 Phosphoserine
    153-153 Phosphotyrosine; by JAK2
    174-174 Phosphoserine
    185-185 Phosphothreonine
    199-199 Phosphoserine; by autocatalysis
    201-201 Phosphotyrosine; by JAK2
    204-204 Phosphoserine
    212-212 Phosphothreonine
    219-219 Phosphothreonine
    220-220 Phosphoserine
    223-223 Phosphoserine
    225-225 Phosphothreonine
    229-229 Phosphothreonine
    230-230 Phosphothreonine
    285-285 Phosphotyrosine; by JAK2
    423-423 Phosphothreonine; by autocatalysis
Seqacetylation
    2-2 N-acetylserine
 
Prediction
DICHOT
Disorder 1-77,148-248,542-545
Known Domain 78-147,249-541
SCOPe RPS-Blast
     1ej5A 79-179 4e-04 a.68.1.1 Wiscott-Aldrich syndrome protein, WASP, ...
     2j0iA 249-538 e-168 d.144.1.0 automated matches
SCOP Hmmer
     2jflA1 261-522 4.2e-89 Protein kinase-like (PK...
Pfam RPS-Blast
     PF00786 76-131 6e-13 P21-Rho-binding domain
     PF06293 341-411 2e-05 Lipopolysaccharide kinase (...
     PF14531 386-453 1e-06 Kinase-like
Pfam Hmmer
    PF00786 74-132 3.2e-28 P21-Rho-binding domain
    PF00069 270-521 1.4e-76 Protein kinase domain