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IID00279  Rho guanine nucleotide exchange factor 7 (Homo sapiens) Q14155
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
803
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-137 Monomer :
 Evidence NMR 2l3g A Reference
       Region 2l3g A 1-137 order
Seq 179-243 Hetero dimer : IID00277Complex
 Evidence NMR 1zsg A Reference
       Region 1zsg A 179-243 order
       Region 1zsg A 179-184 high_rmsd
       Region 1zsg A 243-243 high_rmsd
Seq 183-243 Hetero trimer : IID00178Complex
 Evidence X-RAY 5sxp A Reference
       Region 5sxp A 183-243 order
 Evidence X-RAY 5sxp C Reference
       Region 5sxp C 183-183 disorder
       Region 5sxp C 184-243 order
 Evidence X-RAY 5sxp B Reference
       Region 5sxp B 183-243 order
 Evidence X-RAY 5sxp D Reference
       Region 5sxp D 183-183 disorder
       Region 5sxp D 184-243 order
Seq 260-467 Monomer :
 Evidence NMR 1by1 A Reference
       Region 1by1 A 260-467 order
Seqphosphorylation
    153-153 Phosphoserine
    176-176 Phosphoserine
    249-249 Phosphoserine
    257-257 Phosphoserine
    518-518 Phosphoserine
    694-694 Phosphoserine; by CaMK1
 
Prediction
DICHOT
Disorder 138-181,254-259,579-803
Known Domain 1-137,182-253,260-578
SCOPe RPS-Blast
     2l3gA1 1-137 3e-30 a.40.1.0 automated matches
     2g6fX1 188-241 1e-25 b.34.2.1 53BP2
     1by1A1 260-467 2e-80 a.87.1.1 beta-pix
     1v61A1 460-578 4e-37 b.55.1.1 3-phosphoinositide dependent protein ...
SCOP Hmmer
     1ujoA_ 2-146 4.9e-23 Calponin-homology domain,...
     1ng2A2 186-257 3.5e-26 b.34.2.1 53BP2
     1by1A_ 261-462 1.6e-52 DBL homology domain (DH...
     1v61A_ 454-578 5.2e-38 PH domain-like
Pfam RPS-Blast
     PF16615 139-184 1e-08 Unstructured region one on ...
     PF14604 191-234 5e-13 Variant SH3 domain
     PF16614 632-732 3e-41 Unstructured region two on ...
Pfam Hmmer
    PF00307 4-85 1.1e-11 Calponin homology (CH) domain
    PF16615 138-184 9.4e-20 Unstructured region one on...
    PF07653 189-241 2.8e-21 Variant SH3 domain
    PF00621 275-448 1.2e-35 RhoGEF domain
    PF00169 495-577 3.3e-12 PH domain
    PF16614 635-732 7.5e-53 Unstructured region two on...