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IID00293  Receptor tyrosine-protein kinase erbB-2 (Homo sapiens) P04626
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
1255
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 22-530 Monomer :
 Evidence X-RAY 2a91 A Reference
       Region 2a91 A 22-123 order
       Region 2a91 A 124-127 disorder
       Region 2a91 A 128-530 order
Seq 23-214 Hetero dimer :
 Evidence X-RAY 3h3b A Reference
       Region 3h3b A 23-214 order
Seq 23-214 Hetero dimer :
 Evidence X-RAY 3h3b B Reference
       Region 3h3b B 23-199 order
       Region 3h3b B 200-202 disorder
       Region 3h3b B 203-213 order
       Region 3h3b B 214-214 disorder
Seq 23-586 Hetero trimer :
 Evidence X-RAY 3wlw A Reference
       Region 3wlw A 23-123 order
       Region 3wlw A 124-132 disorder
       Region 3wlw A 133-586 order
Seq 23-586 Hetero trimer :
 Evidence X-RAY 3wlw B Reference
       Region 3wlw B 23-123 order
       Region 3wlw B 124-132 disorder
       Region 3wlw B 133-586 order
Seq 23-586 Hetero trimer :
 Evidence X-RAY 3wsq A Reference
       Region 3wsq A 23-123 order
       Region 3wsq A 124-132 disorder
       Region 3wsq A 133-586 order
Seq 23-629 Hetero trimer :
 Evidence X-RAY 1n8z C Reference
       Region 1n8z C 23-123 order
       Region 1n8z C 124-132 disorder
       Region 1n8z C 133-324 order
       Region 1n8z C 325-327 disorder
       Region 1n8z C 328-382 order
       Region 1n8z C 383-386 disorder
       Region 1n8z C 387-602 order
       Region 1n8z C 603-612 disorder
       Region 1n8z C 613-629 order
Seq 23-646 Hetero dimer : P38507
 Evidence X-RAY 3mzw A Reference
       Region 3mzw A 23-123 order
       Region 3mzw A 124-132 disorder
       Region 3mzw A 133-600 order
       Region 3mzw A 601-646 disorder
Seq 23-646 Hetero nonamer :
 Evidence X-RAY 3n85 A Reference
       Region 3n85 A 23-122 order
       Region 3n85 A 123-132 disorder
       Region 3n85 A 133-269 order
       Region 3n85 A 270-274 disorder
       Region 3n85 A 275-642 order
       Region 3n85 A 643-646 disorder
Seq 23-646 Hetero trimer : Q7Z3Y4
 Evidence X-RAY 1s78 B Reference
       Region 1s78 B 23-123 order
       Region 1s78 B 124-132 disorder
       Region 1s78 B 133-599 order
       Region 1s78 B 600-646 disorder
Seq 23-646 Hetero trimer : Q7Z3Y4
 Evidence X-RAY 1s78 A Reference
       Region 1s78 A 23-123 order
       Region 1s78 A 124-132 disorder
       Region 1s78 A 133-586 order
       Region 1s78 A 587-646 disorder
Seq 23-646 Hetero trimer : P01834,P01857
 Evidence X-RAY 3be1 A Reference
       Region 3be1 A 23-122 order
       Region 3be1 A 123-132 disorder
       Region 3be1 A 133-383 order
       Region 3be1 A 384-387 disorder
       Region 3be1 A 388-602 order
       Region 3be1 A 603-612 disorder
       Region 3be1 A 613-629 order
       Region 3be1 A 630-646 disorder
Seq 23-653 Hetero tetramer : P01857
 Evidence X-RAY 5k33 C Reference
       Region 5k33 C 23-124 order
       Region 5k33 C 125-129 disorder
       Region 5k33 C 130-324 order
       Region 5k33 C 325-327 disorder
       Region 5k33 C 328-385 order
       Region 5k33 C 386-388 disorder
       Region 5k33 C 389-589 order
       Region 5k33 C 590-591 disorder
       Region 5k33 C 592-598 order
       Region 5k33 C 599-629 disorder
 Evidence X-RAY 5kwg C Reference
       Region 5kwg C 23-124 order
       Region 5kwg C 125-129 disorder
       Region 5kwg C 130-324 order
       Region 5kwg C 325-327 disorder
       Region 5kwg C 328-385 order
       Region 5kwg C 386-388 disorder
       Region 5kwg C 389-588 order
       Region 5kwg C 589-591 disorder
       Region 5kwg C 592-597 order
       Region 5kwg C 598-653 disorder
Seq 24-219 Hetero tetramer :
 Evidence X-RAY 4hrm A Reference
       Region 4hrm A 24-27 disorder
       Region 4hrm A 28-36 order
       Region 4hrm A 37-37 disorder
       Region 4hrm A 38-54 order
       Region 4hrm A 55-55 disorder
       Region 4hrm A 56-56 order
       Region 4hrm A 57-57 disorder
       Region 4hrm A 58-66 order
       Region 4hrm A 67-68 disorder
       Region 4hrm A 69-73 order
       Region 4hrm A 74-74 disorder
       Region 4hrm A 75-111 order
       Region 4hrm A 112-112 disorder
       Region 4hrm A 113-119 order
       Region 4hrm A 120-134 disorder
       Region 4hrm A 135-148 order
       Region 4hrm A 149-149 disorder
       Region 4hrm A 150-173 order
       Region 4hrm A 174-176 disorder
       Region 4hrm A 177-184 order
       Region 4hrm A 185-186 disorder
       Region 4hrm A 187-189 order
       Region 4hrm A 190-191 disorder
       Region 4hrm A 192-194 order
       Region 4hrm A 195-202 disorder
       Region 4hrm A 203-204 order
       Region 4hrm A 205-219 disorder
 Evidence X-RAY 4hrm C Reference
       Region 4hrm C 24-26 order
       Region 4hrm C 27-27 disorder
       Region 4hrm C 28-120 order
       Region 4hrm C 121-134 disorder
       Region 4hrm C 135-184 order
       Region 4hrm C 185-186 disorder
       Region 4hrm C 187-187 order
       Region 4hrm C 188-191 disorder
       Region 4hrm C 192-199 order
       Region 4hrm C 200-201 disorder
       Region 4hrm C 202-209 order
       Region 4hrm C 210-210 disorder
       Region 4hrm C 211-213 order
       Region 4hrm C 214-219 disorder
Seq 24-219 Hetero dimer :
 Evidence X-RAY 4hrl C Reference
       Region 4hrl C 24-36 order
       Region 4hrl C 37-38 disorder
       Region 4hrl C 39-39 order
       Region 4hrl C 40-40 disorder
       Region 4hrl C 41-121 order
       Region 4hrl C 122-132 disorder
       Region 4hrl C 133-186 order
       Region 4hrl C 187-191 disorder
       Region 4hrl C 192-199 order
       Region 4hrl C 200-201 disorder
       Region 4hrl C 202-213 order
       Region 4hrl C 214-219 disorder
Seq 24-645 Hetero dimer :
 Evidence X-RAY 5my6 A Reference
       Region 5my6 A 24-122 order
       Region 5my6 A 123-131 disorder
       Region 5my6 A 132-334 order
       Region 5my6 A 335-336 disorder
       Region 5my6 A 337-587 order
       Region 5my6 A 588-594 disorder
       Region 5my6 A 595-597 order
       Region 5my6 A 598-645 disorder
Seq 529-625 Hetero dimer :
 Evidence X-RAY 4hrn C This region binds to a peptide. Reference
       Region 4hrn C 529-530 disorder
       Region 4hrn C 531-601 order
       Region 4hrn C 602-625 disorder
Seq 529-625 Hetero dimer :
 Evidence X-RAY 4hrn D This region binds to a peptide. Reference
       Region 4hrn D 529-530 disorder
       Region 4hrn D 531-600 order
       Region 4hrn D 601-625 disorder
Seq 641-684 Homo dimer :
 Evidence NMR 5ob4 A Reference
       Region 5ob4 A 641-684 order
       Region 5ob4 A 641-646 high_rmsd
       Region 5ob4 A 680-684 high_rmsd
 Evidence NMR 5ob4 B Reference
       Region 5ob4 B 641-684 order
       Region 5ob4 B 641-645 high_rmsd
       Region 5ob4 B 680-684 high_rmsd
 Evidence NMR 2jwa A Reference
       Region 2jwa A 641-684 order
       Region 2jwa A 641-647 high_rmsd
       Region 2jwa A 681-684 high_rmsd
 Evidence NMR 2jwa B Reference
       Region 2jwa B 641-684 order
       Region 2jwa B 641-647 high_rmsd
       Region 2jwa B 680-684 high_rmsd
Seq 641-684 Hetero dimer : IID00262Complex
 Evidence NMR 2ks1 A Reference
       Region 2ks1 A 641-684 order
       Region 2ks1 A 641-646 high_rmsd
       Region 2ks1 A 679-684 high_rmsd
Seq 644-700 Homo dimer :
 Evidence NMR 2n2a A Reference
       Region 2n2a A 644-700 order
 Evidence NMR 2n2a B Reference
       Region 2n2a B 644-700 order
Seq 654-662 Hetero trimer : P01892
 Evidence X-RAY 1qr1 C Reference
       Region 1qr1 C 654-662 order
 Evidence X-RAY 1qr1 F Reference
       Region 1qr1 F 654-662 order
Seq 703-1029 Monomer :
 Evidence X-RAY 3pp0 A Reference
       Region 3pp0 A 703-705 disorder
       Region 3pp0 A 706-879 order
       Region 3pp0 A 880-881 disorder
       Region 3pp0 A 882-993 order
       Region 3pp0 A 994-1029 disorder
 Evidence X-RAY 3pp0 B Reference
       Region 3pp0 B 703-705 disorder
       Region 3pp0 B 706-879 order
       Region 3pp0 B 880-881 disorder
       Region 3pp0 B 882-992 order
       Region 3pp0 B 993-998 disorder
       Region 3pp0 B 999-1009 order
       Region 3pp0 B 1010-1029 disorder
 Evidence X-RAY 3rcd A Reference
       Region 3rcd A 713-756 order
       Region 3rcd A 757-760 disorder
       Region 3rcd A 761-866 order
       Region 3rcd A 867-883 disorder
       Region 3rcd A 884-991 order
       Region 3rcd A 992-999 disorder
       Region 3rcd A 1000-1012 order
       Region 3rcd A 1013-1015 disorder
       Region 3rcd A 1016-1022 order
       Region 3rcd A 1023-1028 disorder
 Evidence X-RAY 3rcd B Reference
       Region 3rcd B 713-756 order
       Region 3rcd B 757-760 disorder
       Region 3rcd B 761-865 order
       Region 3rcd B 866-883 disorder
       Region 3rcd B 884-991 order
       Region 3rcd B 992-999 disorder
       Region 3rcd B 1000-1010 order
       Region 3rcd B 1011-1028 disorder
 Evidence X-RAY 3rcd C Reference
       Region 3rcd C 713-756 order
       Region 3rcd C 757-760 disorder
       Region 3rcd C 761-866 order
       Region 3rcd C 867-883 disorder
       Region 3rcd C 884-991 order
       Region 3rcd C 992-999 disorder
       Region 3rcd C 1000-1012 order
       Region 3rcd C 1013-1015 disorder
       Region 3rcd C 1016-1022 order
       Region 3rcd C 1023-1028 disorder
 Evidence X-RAY 3rcd D Reference
       Region 3rcd D 713-756 order
       Region 3rcd D 757-760 disorder
       Region 3rcd D 761-865 order
       Region 3rcd D 866-883 disorder
       Region 3rcd D 884-991 order
       Region 3rcd D 992-999 disorder
       Region 3rcd D 1000-1010 order
       Region 3rcd D 1011-1028 disorder
Seq 1135-1144 Hetero dimer : IID00566Complex
 Evidence NMR 2l4k B Reference
       Region 2l4k B 1135-1138 disorder
       Region 2l4k B 1139-1142 order
       Region 2l4k B 1143-1144 disorder
 Evidence NMR 1mw4 B Reference
       Region 1mw4 B 1135-1138 disorder
       Region 1mw4 B 1139-1142 order
       Region 1mw4 B 1143-1144 disorder
Seq 1218-1228 Hetero dimer : P08487
 Evidence X-RAY 5tqs E Reference
       Region 5tqs E 1218-1219 disorder
       Region 5tqs E 1220-1225 order
       Region 5tqs E 1226-1228 disorder
 Evidence X-RAY 5tqs F Reference
       Region 5tqs F 1218-1218 disorder
       Region 5tqs F 1219-1225 order
       Region 5tqs F 1226-1228 disorder
 Evidence X-RAY 5tqs G Reference
       Region 5tqs G 1218-1225 order
       Region 5tqs G 1226-1228 disorder
 Evidence X-RAY 5tqs H Reference
       Region 5tqs H 1218-1224 order
       Region 5tqs H 1225-1228 disorder
Seq 1246-1252 Hetero dimer : IID00581Complex
 Evidence X-RAY 4gfu F Reference
       Region 4gfu F 1246-1252 order
Seq 1247-1255 Hetero dimer : IID00494Complex
 Evidence X-RAY 1mfg B Reference
       Region 1mfg B 1247-1255 order
 Evidence X-RAY 1mfl B Reference
       Region 1mfl B 1247-1250 disorder
       Region 1mfl B 1251-1255 order
SeqProS possible 1139-1142 SH2 binding motif Hetero dimer : IID00566Complex
       Region 2l4k B 1139-1142 order
       Region 1mw4 B 1139-1142 order
SeqProS possible 1247-1250,1251-1255 This region may be disordered in the free state same as phosphorylated form(1mfl). Hetero dimer : IID00494Complex
       Region 1mfg B 1247-1255 order
       Region 1mfl B 1251-1255 order
       Region 1mfl B 1247-1250 disorder
Seqphosphorylation
    182-182 Phosphothreonine
    1054-1054 Phosphoserine
    1078-1078 Phosphoserine
    1083-1083 Phosphoserine
    1107-1107 Phosphoserine
    1112-1112 Phosphotyrosine
    1139-1139 Phosphotyrosine
    1151-1151 Phosphoserine
    1166-1166 Phosphothreonine
    1196-1196 Phosphotyrosine
    1248-1248 Phosphotyrosine; by autocatalysis
 
Prediction
DICHOT
Disorder 1-22,630-652,676-706,994-1255
Known Domain 23-629,653-675,707-993
SCOPe RPS-Blast
     3h3bA1 23-187 1e-45 c.10.2.5 EGF receptor extracellular domain
     1n8yC3 187-343 3e-42 g.3.9.1 EGF receptor Cys-rich domains
     3h3bA2 188-214 2e-06 g.3.9.0 automated matches
     1n8yC2 344-509 5e-39 c.10.2.5 EGF receptor extracellular domain
     1n8yC4 511-629 3e-34 g.3.9.1 EGF receptor Cys-rich domains
     3pozA 709-1024 e-158 d.144.1.7 3-phosphoinositide dependent protein...
SCOP Hmmer
     1igrA2 47-214 6.3e-44 c.10.2.5 EGF receptor ext...
     1n8yC3 189-343 9.3e-18 g.3.9.1 EGF receptor Cys...
     1n8zC2 337-525 8.1e-44 c.10.2.5 EGF receptor ex...
     1m6bB4 511-642 3.1e-23 g.3.9.1 EGF receptor Cys...
     1m14A_ 716-992 3.5e-79 d.144.1.7 3-phosphoinosi...
Pfam RPS-Blast
     PF01030 52-172 1e-12 Receptor L domain
     PF00757 185-343 1e-39 Furin-like cysteine rich re...
     PF01030 366-485 2e-18 Receptor L domain
     PF14843 511-642 1e-24 Growth factor receptor doma...
     PF06293 796-880 7e-04 Lipopolysaccharide kinase (...
     PF06566 1048-1247 2e-04 Chondroitin sulphate atta...
Pfam Hmmer
    PF01030 52-172 3.5e-36 Receptor L domain
    PF00757 190-343 1.5e-28 Furin-like cysteine rich r...
    PF01030 366-485 1.1e-22 Receptor L domain
    PF14843 511-642 8.9e-45 Growth factor receptor dom...
    PF07714 721-975 1.9e-89 Protein tyrosine kinase