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IID00302  Alpha-synuclein (Homo sapiens) P37840
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
140
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-12 Monomer :
 Evidence NMR 2jn5 A Reference
       Region 2jn5 A 1-12 order
Seq 1-19 Hetero dimer : IID90020Complex
 Evidence X-RAY 3q25 A Reference
       Region 3q25 A 1-19 order
Seq 1-19 Hetero dimer : P0DP23
 Evidence NMR 2m55 B Reference
       Region 2m55 B 1-19 order
       Region 2m55 B 17-19 high_rmsd
Seq 1-19 Hetero tetramer : IID90020Complex
 Evidence X-RAY 3q29 A Reference
       Region 3q29 A 1-11 order
       Region 3q29 A 12-19 disorder
 Evidence X-RAY 3q29 C Reference
       Region 3q29 C 1-14 order
       Region 3q29 C 15-19 disorder
Seq 1-140 Homo decamer :
 Evidence NMR 2n0a A Reference
       Region 2n0a A 1-140 order
 Evidence NMR 2n0a B Reference
       Region 2n0a B 1-140 order
 Evidence NMR 2n0a C Reference
       Region 2n0a C 1-140 order
 Evidence NMR 2n0a D Reference
       Region 2n0a D 1-140 order
 Evidence NMR 2n0a E Reference
       Region 2n0a E 1-140 order
 Evidence NMR 2n0a F Reference
       Region 2n0a F 1-140 order
 Evidence NMR 2n0a G Reference
       Region 2n0a G 1-140 order
 Evidence NMR 2n0a H Reference
       Region 2n0a H 1-140 order
 Evidence NMR 2n0a I Reference
       Region 2n0a I 1-140 order
 Evidence NMR 2n0a J Reference
       Region 2n0a J 1-140 order
Seqdisorder 1-140
 Evidence CD Reference
       Region 1-140 disorder
Seq 1-140 Monomer :
 Evidence NMR 2kkw A Reference
       Region 2kkw A 1-93 order
       Region 2kkw A 94-140 disorder
 Evidence NMR 1xq8 A Reference
       Region 1xq8 A 1-97 order
       Region 1xq8 A 98-140 disorder
Seq 10-42 Hetero dimer : IID90020Complex
 Evidence X-RAY 3q26 A Reference
       Region 3q26 A 10-11 order
       Region 3q26 A 12-19 disorder
       Region 3q26 A 20-42 order
Seq 31-41 Hetero dimer : IID50214Complex
 Evidence X-RAY 5crw B Reference
       Region 5crw B 31-41 order
Seq 32-57 Hetero dimer : IID90020Complex
 Evidence X-RAY 3q27 A Reference
       Region 3q27 A 32-36 disorder
       Region 3q27 A 37-56 order
       Region 3q27 A 57-57 disorder
Seq 35-56 Hetero trimer :
 Evidence NMR 4bxl C Reference
       Region 4bxl C 35-56 order
Seq 58-79 Hetero dimer : IID90020Complex
 Evidence X-RAY 3q28 A Reference
       Region 3q28 A 58-72 order
       Region 3q28 A 73-79 disorder
Seq 69-78 Homo decamer :
 Evidence X-RAY 4r0u A Reference
       Region 4r0u A 72-78 order
 Evidence X-RAY 4r0w A Reference
       Region 4r0w A 70-76 order
 Evidence X-RAY 4rik A Reference
       Region 4rik A 69-77 order
Seq 132-140 Hetero dimer :
 Evidence X-RAY 2x6m B Reference
       Region 2x6m B 132-134 disorder
       Region 2x6m B 135-140 order
SeqProS verified 1-12 This region is ordered in the complex with Synphilin-1 :
       Region 2jn5 A 1-12 order
       Region 1-140 disorder
SeqProS verified 1-14 Hetero tetramer : IID90020Complex
       Region 3q29 A 1-11 order
       Region 3q29 C 1-14 order
       Region 1-140 disorder
SeqProS verified 1-19 Hetero dimer : P0DP23
       Region 2m55 B 1-19 order
       Region 1-140 disorder
SeqProS verified 1-19 Hetero dimer : IID90020Complex
       Region 3q25 A 1-19 order
       Region 1-140 disorder
SeqProS verified 1-97 This region is ordered in the micelle bound. (in vitro) :
       Region 1xq8 A 1-97 order
       Region 2kkw A 1-93 order
       Region 1-140 disorder
SeqProS verified 10-11,20-42 Hetero dimer : IID90020Complex
       Region 3q26 A 20-42 order
       Region 3q26 A 10-11 order
       Region 1-140 disorder
SeqProS verified 31-41 Hetero dimer : IID50214Complex
       Region 5crw B 31-41 order
       Region 1-140 disorder
SeqProS verified 35-56 This region is ordered in the complex with beta wrapin AS69(engineered protein). Hetero trimer :
       Region 4bxl C 35-56 order
       Region 1-140 disorder
SeqProS verified 37-56 Hetero dimer : IID90020Complex
       Region 3q27 A 37-56 order
       Region 1-140 disorder
SeqProS verified 58-72 Hetero dimer : IID90020Complex
       Region 3q28 A 58-72 order
       Region 1-140 disorder
SeqProS verified 135-140 This region is ordered in the complex with NbSyn2. (in vitro) Hetero dimer :
       Region 2x6m B 135-140 order
       Region 1-140 disorder
Seqphosphorylation
    87-87 Phosphoserine
    125-125 Phosphotyrosine; by FYN
    129-129 Phosphoserine; by BARK1
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
DICHOT
Known Domain 1-140
SCOP Hmmer
     1xq8A_ 1-140 6.9e-67 h.7.1.1 Alpha-synuclein
Pfam RPS-Blast
     PF01387 1-46 2e-07 Synuclein
Pfam Hmmer
    PF01387 1-130 7.9e-58 Synuclein