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IID00354  Bone morphogenetic protein 2 (Homo sapiens) P12643
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
396
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 283-314 Hetero tetramer : IID00338Complex
 Evidence X-RAY 4mid A Reference
       Region 4mid A 283-291 disorder
       Region 4mid A 292-314 order
Seq 283-396 Hetero hexamer : IID50131Complex,P36894
 Evidence X-RAY 2h64 A Reference
       Region 2h64 A 283-291 disorder
       Region 2h64 A 292-396 order
Seq 283-396 Hetero trimer : Q6NW40
 Evidence X-RAY 4ui0 A Reference
       Region 4ui0 A 283-292 disorder
       Region 4ui0 A 293-332 order
       Region 4ui0 A 333-335 disorder
       Region 4ui0 A 336-396 order
 Evidence X-RAY 4ui0 B Reference
       Region 4ui0 B 283-292 disorder
       Region 4ui0 B 293-396 order
Seq 283-396 Hetero tetramer : IID50132Complex
 Evidence X-RAY 3bk3 A Reference
       Region 3bk3 A 283-292 disorder
       Region 3bk3 A 293-396 order
 Evidence X-RAY 3bk3 B Reference
       Region 3bk3 B 283-292 disorder
       Region 3bk3 B 293-396 order
Seq 283-305,362-396 Hetero hexamer : IID00577Complex
 Evidence X-RAY 4n1d A Reference
       Region 4n1d A 283-292 disorder
       Region 4n1d A 293-305 order
       Region 4n1d A 362-396 order
Seq 283-396 Hetero octamer : P97798,Q6NW40
 Evidence X-RAY 4ui2 B Reference
       Region 4ui2 B 283-292 disorder
       Region 4ui2 B 293-396 order
Seq 283-396 Hetero tetramer : P36894,Q13705
 Evidence X-RAY 2h62 A Reference
       Region 2h62 A 283-292 disorder
       Region 2h62 A 293-396 order
 Evidence X-RAY 2h62 B Reference
       Region 2h62 B 283-293 disorder
       Region 2h62 B 294-396 order
Seq 283-396 Hetero dimer : Q6ZVN8
 Evidence X-RAY 4ui1 A Reference
       Region 4ui1 A 283-292 disorder
       Region 4ui1 A 293-396 order
 Evidence X-RAY 4ui1 B Reference
       Region 4ui1 B 283-291 disorder
       Region 4ui1 B 292-396 order
Seq 283-396 Hetero dimer : Q6NW40
 Evidence X-RAY 4uhz A Reference
       Region 4uhz A 283-292 disorder
       Region 4uhz A 293-396 order
Seq 283-396 Hetero tetramer : P36894
 Evidence X-RAY 1es7 A Reference
       Region 1es7 A 283-292 disorder
       Region 1es7 A 293-396 order
 Evidence X-RAY 1es7 C Reference
       Region 1es7 C 283-292 disorder
       Region 1es7 C 293-396 order
 Evidence X-RAY 2qj9 A Reference
       Region 2qj9 A 283-292 disorder
       Region 2qj9 A 293-396 order
 Evidence X-RAY 2qj9 B Reference
       Region 2qj9 B 283-293 disorder
       Region 2qj9 B 294-396 order
 Evidence X-RAY 2qja A Reference
       Region 2qja A 283-292 disorder
       Region 2qja A 293-396 order
 Evidence X-RAY 2qja B Reference
       Region 2qja B 283-292 disorder
       Region 2qja B 293-396 order
 Evidence X-RAY 2qjb A Reference
       Region 2qjb A 283-293 disorder
       Region 2qjb A 294-396 order
 Evidence X-RAY 2qjb B Reference
       Region 2qjb B 283-292 disorder
       Region 2qjb B 293-396 order
 Evidence X-RAY 1rew A Reference
       Region 1rew A 283-293 disorder
       Region 1rew A 294-396 order
 Evidence X-RAY 1rew B Reference
       Region 1rew B 283-293 disorder
       Region 1rew B 294-396 order
Seq 283-396 Hetero hexamer : P27038,P36894
 Evidence X-RAY 2goo A Reference
       Region 2goo A 283-293 disorder
       Region 2goo A 294-396 order
 Evidence X-RAY 2goo D Reference
       Region 2goo D 283-292 disorder
       Region 2goo D 293-396 order
Seq 283-396 Homo dimer :
 Evidence X-RAY 3bmp A As temperature factors are high at the pre-helix loop (residue number:330-335) in 3bmp, these regions are flexible. But that of 1rew are much lower. Probably because of complex formation, the segment becomes rigid. Reference
       Region 3bmp A 283-290 disorder
       Region 3bmp A 291-396 order
 Evidence X-RAY 1reu A Reference
       Region 1reu A 294-396 order
Seq 283-396 Hetero trimer : Q96B86
 Evidence X-RAY 4uhy A Reference
       Region 4uhy A 283-292 disorder
       Region 4uhy A 293-396 order
 Evidence X-RAY 4uhy B Reference
       Region 4uhy B 283-291 disorder
       Region 4uhy B 292-396 order
Seqphosphorylation
    87-87 Phosphoserine
 
Prediction
DICHOT
Disorder 1-6,30-75,271-293
Known Domain 7-29,76-270,294-396
SCOPe RPS-Blast
     1rewA 294-396 2e-60 g.17.1.2 Activin A (Inhibin beta A)
SCOP Hmmer
     1nysB_ 290-396 7.7e-45 g.17.1.2 Activin A (Inhi...
Pfam RPS-Blast
     PF00688 37-270 8e-15 TGF-beta propeptide
     PF00019 295-395 3e-17 Transforming growth factor ...
Pfam Hmmer
    PF00688 42-267 1e-56 TGF-beta propeptide
    PF00019 295-395 2.1e-38 Transforming growth factor...