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IID00412  RAC-alpha serine/threonine-protein kinase (Homo sapiens) P31749
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
480
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-123 Monomer :
 Evidence X-RAY 1h10 A Reference
       Region 1h10 A 1-116 order
       Region 1h10 A 117-123 disorder
 Evidence X-RAY 1unp A Reference
       Region 1unp A 1-2 disorder
       Region 1unp A 3-121 order
 Evidence X-RAY 1unq A Reference
       Region 1unq A 1-116 order
       Region 1unq A 117-123 disorder
 Evidence X-RAY 1unr A Reference
       Region 1unr A 1-2 disorder
       Region 1unr A 3-42 order
       Region 1unr A 43-47 disorder
       Region 1unr A 48-120 order
       Region 1unr A 121-123 disorder
 Evidence X-RAY 2uvm A Reference
       Region 2uvm A 1-115 order
       Region 2uvm A 116-123 disorder
 Evidence X-RAY 2uzr A Reference
       Region 2uzr A 1-2 disorder
       Region 2uzr A 3-42 order
       Region 2uzr A 43-47 disorder
       Region 2uzr A 48-120 order
       Region 2uzr A 121-123 disorder
 Evidence X-RAY 2uzs A Reference
       Region 2uzs A 1-116 order
       Region 2uzs A 117-123 disorder
Seq 2-446 Monomer :
 Evidence X-RAY 4ejn A Reference
       Region 4ejn A 2-3 disorder
       Region 4ejn A 4-42 order
       Region 4ejn A 43-49 disorder
       Region 4ejn A 50-109 order
       Region 4ejn A 110-143 disorder
       Region 4ejn A 144-187 order
       Region 4ejn A 188-200 disorder
       Region 4ejn A 201-301 order
       Region 4ejn A 302-306 disorder
       Region 4ejn A 307-438 order
       Region 4ejn A 439-446 disorder
 Evidence X-RAY 5kcv A Reference
       Region 5kcv A 2-5 disorder
       Region 5kcv A 6-19 order
       Region 5kcv A 20-20 disorder
       Region 5kcv A 21-42 order
       Region 5kcv A 43-49 disorder
       Region 5kcv A 50-104 order
       Region 5kcv A 105-143 disorder
       Region 5kcv A 144-183 order
       Region 5kcv A 184-200 disorder
       Region 5kcv A 201-296 order
       Region 5kcv A 297-312 disorder
       Region 5kcv A 313-438 order
       Region 5kcv A 439-446 disorder
 Evidence X-RAY 3o96 A Reference
       Region 3o96 A 2-45 order
       Region 3o96 A 46-48 disorder
       Region 3o96 A 49-88 order
       Region 3o96 A 89-91 disorder
       Region 3o96 A 92-113 order
       Region 3o96 A 114-144 disorder
       Region 3o96 A 145-188 order
       Region 3o96 A 189-198 disorder
       Region 3o96 A 199-298 order
       Region 3o96 A 299-312 disorder
       Region 3o96 A 313-429 order
       Region 3o96 A 430-443 disorder
Seq 144-480 Hetero dimer :
 Evidence X-RAY 3qkl A Reference
       Region 3qkl A 144-448 order
       Region 3qkl A 449-465 disorder
       Region 3qkl A 466-478 order
       Region 3qkl A 479-480 disorder
Seq 144-480 Hetero dimer : IID00052Complex
 Evidence X-RAY 3cqu A Reference
       Region 3cqu A 144-446 order
       Region 3cqu A 447-462 disorder
       Region 3cqu A 463-478 order
       Region 3cqu A 479-480 disorder
 Evidence X-RAY 3cqw A Reference
       Region 3cqw A 144-447 order
       Region 3cqw A 448-463 disorder
       Region 3cqw A 464-478 order
       Region 3cqw A 479-480 disorder
 Evidence X-RAY 4ekk A Reference
       Region 4ekk A 144-447 order
       Region 4ekk A 448-462 disorder
       Region 4ekk A 463-477 order
       Region 4ekk A 478-480 disorder
 Evidence X-RAY 4ekk B Reference
       Region 4ekk B 144-447 order
       Region 4ekk B 448-462 disorder
       Region 4ekk B 463-477 order
       Region 4ekk B 478-480 disorder
 Evidence X-RAY 3mv5 A Reference
       Region 3mv5 A 144-447 order
       Region 3mv5 A 448-465 disorder
       Region 3mv5 A 466-477 order
       Region 3mv5 A 478-480 disorder
 Evidence X-RAY 3ow4 A Reference
       Region 3ow4 A 144-448 order
       Region 3ow4 A 449-465 disorder
       Region 3ow4 A 466-478 order
       Region 3ow4 A 479-480 disorder
 Evidence X-RAY 3ow4 B Reference
       Region 3ow4 B 144-448 order
       Region 3ow4 B 449-465 disorder
       Region 3ow4 B 466-478 order
       Region 3ow4 B 479-480 disorder
 Evidence X-RAY 3qkk A Reference
       Region 3qkk A 144-449 order
       Region 3qkk A 450-457 disorder
       Region 3qkk A 458-478 order
       Region 3qkk A 479-480 disorder
Seq 144-480 Hetero dimer :
 Evidence X-RAY 3mvh A Reference
       Region 3mvh A 144-144 disorder
       Region 3mvh A 145-445 order
       Region 3mvh A 446-465 disorder
       Region 3mvh A 466-476 order
       Region 3mvh A 477-480 disorder
Seq 144-480 Monomer :
 Evidence X-RAY 4ekl A Reference
       Region 4ekl A 144-451 order
       Region 4ekl A 452-456 disorder
       Region 4ekl A 457-478 order
       Region 4ekl A 479-480 disorder
 Evidence X-RAY 4gv1 A Reference
       Region 4gv1 A 144-451 order
       Region 4gv1 A 452-456 disorder
       Region 4gv1 A 457-477 order
       Region 4gv1 A 478-480 disorder
 Evidence X-RAY 3qkm A Reference
       Region 3qkm A 144-451 order
       Region 3qkm A 452-456 disorder
       Region 3qkm A 457-478 order
       Region 3qkm A 479-480 disorder
Seq 144-480 Hetero dimer :
 Evidence X-RAY 3ocb B Reference
       Region 3ocb B 144-450 order
       Region 3ocb B 451-465 disorder
       Region 3ocb B 466-478 order
       Region 3ocb B 479-480 disorder
Seq 144-480 Hetero dimer :
 Evidence X-RAY 3ocb A Reference
       Region 3ocb A 144-446 order
       Region 3ocb A 447-465 disorder
       Region 3ocb A 466-478 order
       Region 3ocb A 479-480 disorder
SeqProS verified 189-198,299-312 This region is activation segment. :
       Region 3qkm A 144-451 order
       Region 3o96 A 189-198 disorder
       Region 3o96 A 299-312 disorder
SeqProS verified 189-198,299-312 This region is activation segment. Hetero dimer :
       Region 3ocb B 144-450 order
       Region 3o96 A 189-198 disorder
       Region 3o96 A 299-312 disorder
SeqProS verified 189-198,299-312 This region is activation segment. Hetero dimer : IID00052Complex
       Region 3ow4 A 144-448 order
       Region 3ow4 B 144-448 order
       Region 3cqu A 144-446 order
       Region 3cqw A 144-447 order
       Region 3qkk A 144-449 order
       Region 3mv5 A 144-447 order
       Region 3o96 A 189-198 disorder
       Region 3o96 A 299-312 disorder
SeqProS verified 189-198,299-312 This region is activation segment. Hetero dimer :
       Region 3ocb A 144-446 order
       Region 3o96 A 189-198 disorder
       Region 3o96 A 299-312 disorder
SeqProS verified 189-198,299-312 This region is activation segment. Hetero dimer :
       Region 3mvh A 145-445 order
       Region 3o96 A 189-198 disorder
       Region 3o96 A 299-312 disorder
SeqProS verified 189-198,299-312 This region is activation segment. Hetero dimer :
       Region 3qkl A 144-448 order
       Region 3o96 A 189-198 disorder
       Region 3o96 A 299-312 disorder
Seqphosphorylation
    124-124 Phosphoserine
    126-126 Phosphoserine; alternate
    129-129 Phosphoserine; alternate
    176-176 Phosphotyrosine; by TNK2
    308-308 Phosphothreonine; by IKKE
    448-448 Phosphothreonine
    450-450 Phosphothreonine
    473-473 Phosphoserine; by IKKE
    474-474 Phosphotyrosine
Seqacetylation
    14-14 N6-acetyllysine
    20-20 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-1,478-480
Known Domain 2-477
SCOPe RPS-Blast
     1unqA 1-117 2e-41 b.55.1.1 3-phosphoinositide dependent protein kin...
     1o6lA 144-477 e-174 d.144.1.7 3-phosphoinositide dependent protein k...
SCOP Hmmer
     1h10A_ 1-113 3.6e-26 b.55.1.1 3-phosphoinositid...
     1o6lA_ 145-459 5.5e-100 d.144.1.7 3-phosphoinos...
Pfam RPS-Blast
     PF15413 8-104 1e-04 Pleckstrin homology domain
     PF14531 266-349 5e-08 Kinase-like
Pfam Hmmer
    PF00169 7-106 6.9e-20 PH domain
    PF00069 151-408 9.2e-81 Protein kinase domain
    PF00433 429-474 3.8e-14 Protein kinase C terminal ...