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IID00413  TGF-beta receptor type-1 (Homo sapiens) P36897
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
503
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 31-115 Monomer :
 Evidence NMR 2l5s A Reference
       Region 2l5s A 31-115 order
       Region 2l5s A 92-92 high_rmsd
       Region 2l5s A 112-115 high_rmsd
Seq 31-115 Hetero hexamer : IID00414Complex,IID00534Complex
 Evidence X-RAY 3kfd I Reference
       Region 3kfd I 31-32 disorder
       Region 3kfd I 33-59 order
       Region 3kfd I 60-62 disorder
       Region 3kfd I 63-87 order
       Region 3kfd I 88-95 disorder
       Region 3kfd I 96-109 order
       Region 3kfd I 110-115 disorder
 Evidence X-RAY 3kfd J Reference
       Region 3kfd J 31-32 disorder
       Region 3kfd J 33-62 order
       Region 3kfd J 63-64 disorder
       Region 3kfd J 65-90 order
       Region 3kfd J 91-94 disorder
       Region 3kfd J 95-108 order
       Region 3kfd J 109-115 disorder
 Evidence X-RAY 3kfd K Reference
       Region 3kfd K 31-32 disorder
       Region 3kfd K 33-59 order
       Region 3kfd K 60-62 disorder
       Region 3kfd K 63-87 order
       Region 3kfd K 88-95 disorder
       Region 3kfd K 96-109 order
       Region 3kfd K 110-115 disorder
 Evidence X-RAY 3kfd L Reference
       Region 3kfd L 31-32 disorder
       Region 3kfd L 33-62 order
       Region 3kfd L 63-64 disorder
       Region 3kfd L 65-90 order
       Region 3kfd L 91-94 disorder
       Region 3kfd L 95-108 order
       Region 3kfd L 109-115 disorder
Seq 33-111 Hetero hexamer : IID00355Complex,IID00414Complex
 Evidence X-RAY 2pjy C Reference
       Region 2pjy C 33-111 order
Seq 162-503 Monomer :
 Evidence X-RAY 6b8y A Reference
       Region 6b8y A 200-501 order
       Region 6b8y A 502-503 disorder
 Evidence X-RAY 5e8s A Reference
       Region 5e8s A 200-498 order
       Region 5e8s A 499-503 disorder
 Evidence X-RAY 5e8t A Reference
       Region 5e8t A 200-499 order
       Region 5e8t A 500-503 disorder
 Evidence X-RAY 5e8u A Reference
       Region 5e8u A 200-502 order
       Region 5e8u A 503-503 disorder
 Evidence X-RAY 5e8w A Reference
       Region 5e8w A 200-501 order
       Region 5e8w A 502-503 disorder
 Evidence X-RAY 5e8x A Reference
       Region 5e8x A 200-503 order
 Evidence X-RAY 5e8z A Reference
       Region 5e8z A 200-499 order
       Region 5e8z A 500-503 disorder
 Evidence X-RAY 5e90 A Reference
       Region 5e90 A 200-499 order
       Region 5e90 A 500-503 disorder
 Evidence X-RAY 5fri A Reference
       Region 5fri A 200-498 order
 Evidence X-RAY 3gxl A Reference
       Region 3gxl A 201-224 order
       Region 3gxl A 225-227 disorder
       Region 3gxl A 228-366 order
       Region 3gxl A 367-371 disorder
       Region 3gxl A 372-416 order
       Region 3gxl A 417-419 disorder
       Region 3gxl A 420-457 order
       Region 3gxl A 458-459 disorder
       Region 3gxl A 460-498 order
       Region 3gxl A 499-503 disorder
 Evidence X-RAY 3hmm A Reference
       Region 3hmm A 201-368 order
       Region 3hmm A 369-373 disorder
       Region 3hmm A 374-498 order
       Region 3hmm A 499-503 disorder
 Evidence X-RAY 3kcf A Reference
       Region 3kcf A 162-170 disorder
       Region 3kcf A 171-367 order
       Region 3kcf A 368-369 disorder
       Region 3kcf A 370-500 order
       Region 3kcf A 501-503 disorder
 Evidence X-RAY 3kcf B Reference
       Region 3kcf B 162-170 disorder
       Region 3kcf B 171-320 order
       Region 3kcf B 321-324 disorder
       Region 3kcf B 325-367 order
       Region 3kcf B 368-370 disorder
       Region 3kcf B 371-501 order
       Region 3kcf B 502-503 disorder
 Evidence X-RAY 3kcf C Reference
       Region 3kcf C 162-170 disorder
       Region 3kcf C 171-500 order
       Region 3kcf C 501-503 disorder
 Evidence X-RAY 3kcf D Reference
       Region 3kcf D 162-170 disorder
       Region 3kcf D 171-500 order
       Region 3kcf D 501-503 disorder
 Evidence X-RAY 3kcf E Reference
       Region 3kcf E 162-170 disorder
       Region 3kcf E 171-500 order
       Region 3kcf E 501-503 disorder
 Evidence X-RAY 1py5 A Reference
       Region 1py5 A 175-199 disorder
       Region 1py5 A 200-500 order
 Evidence X-RAY 1rw8 A Reference
       Region 1rw8 A 200-500 order
 Evidence X-RAY 3tzm A Reference
       Region 3tzm A 200-369 order
       Region 3tzm A 370-371 disorder
       Region 3tzm A 372-496 order
       Region 3tzm A 497-503 disorder
 Evidence X-RAY 5usq A Reference
       Region 5usq A 200-498 order
 Evidence X-RAY 1vjy A Reference
       Region 1vjy A 201-367 order
       Region 1vjy A 368-371 disorder
       Region 1vjy A 372-503 order
 Evidence X-RAY 2wot A Reference
       Region 2wot A 200-500 order
       Region 2wot A 501-503 disorder
 Evidence X-RAY 2wou A Reference
       Region 2wou A 200-496 order
       Region 2wou A 497-503 disorder
 Evidence X-RAY 4x0m A Reference
       Region 4x0m A 200-501 order
       Region 4x0m A 502-503 disorder
 Evidence X-RAY 4x2f A Reference
       Region 4x2f A 200-501 order
       Region 4x2f A 502-503 disorder
 Evidence X-RAY 4x2g A Reference
       Region 4x2g A 200-501 order
       Region 4x2g A 502-503 disorder
 Evidence X-RAY 4x2n A Reference
       Region 4x2n A 200-501 order
       Region 4x2n A 502-503 disorder
 Evidence X-RAY 2x7o A Reference
       Region 2x7o A 162-170 disorder
       Region 2x7o A 171-500 order
       Region 2x7o A 501-503 disorder
 Evidence X-RAY 2x7o B Reference
       Region 2x7o B 162-170 disorder
       Region 2x7o B 171-500 order
       Region 2x7o B 501-503 disorder
 Evidence X-RAY 2x7o C Reference
       Region 2x7o C 162-170 disorder
       Region 2x7o C 171-500 order
       Region 2x7o C 501-503 disorder
 Evidence X-RAY 2x7o D Reference
       Region 2x7o D 162-170 disorder
       Region 2x7o D 171-500 order
       Region 2x7o D 501-503 disorder
 Evidence X-RAY 2x7o E Reference
       Region 2x7o E 162-170 disorder
       Region 2x7o E 171-500 order
       Region 2x7o E 501-503 disorder
 Evidence X-RAY 4x2j A Reference
       Region 4x2j A 200-501 order
       Region 4x2j A 502-503 disorder
 Evidence X-RAY 4x2k A Reference
       Region 4x2k A 200-501 order
       Region 4x2k A 502-503 disorder
Seq 162-503 Homo pentamer :
 Evidence X-RAY 1ias A Reference
       Region 1ias A 162-170 disorder
       Region 1ias A 171-500 order
       Region 1ias A 501-503 disorder
 Evidence X-RAY 1ias B Reference
       Region 1ias B 162-170 disorder
       Region 1ias B 171-320 order
       Region 1ias B 321-324 disorder
       Region 1ias B 325-367 order
       Region 1ias B 368-370 disorder
       Region 1ias B 371-501 order
       Region 1ias B 502-503 disorder
 Evidence X-RAY 1ias C Reference
       Region 1ias C 162-170 disorder
       Region 1ias C 171-500 order
       Region 1ias C 501-503 disorder
 Evidence X-RAY 1ias D Reference
       Region 1ias D 162-170 disorder
       Region 1ias D 171-500 order
       Region 1ias D 501-503 disorder
 Evidence X-RAY 1ias E Reference
       Region 1ias E 162-170 disorder
       Region 1ias E 171-500 order
       Region 1ias E 501-503 disorder
 Evidence X-RAY 3faa A Reference
       Region 3faa A 162-170 disorder
       Region 3faa A 171-367 order
       Region 3faa A 368-369 disorder
       Region 3faa A 370-500 order
       Region 3faa A 501-503 disorder
 Evidence X-RAY 3faa B Reference
       Region 3faa B 162-170 disorder
       Region 3faa B 171-320 order
       Region 3faa B 321-324 disorder
       Region 3faa B 325-367 order
       Region 3faa B 368-370 disorder
       Region 3faa B 371-501 order
       Region 3faa B 502-503 disorder
 Evidence X-RAY 3faa C Reference
       Region 3faa C 162-170 disorder
       Region 3faa C 171-500 order
       Region 3faa C 501-503 disorder
 Evidence X-RAY 3faa D Reference
       Region 3faa D 162-170 disorder
       Region 3faa D 171-500 order
       Region 3faa D 501-503 disorder
 Evidence X-RAY 3faa E Reference
       Region 3faa E 162-170 disorder
       Region 3faa E 171-500 order
       Region 3faa E 501-503 disorder
Seq 162-503 Hetero dimer : P62942
 Evidence X-RAY 1b6c B Reference
       Region 1b6c B 162-174 disorder
       Region 1b6c B 175-500 order
       Region 1b6c B 501-503 disorder
 Evidence X-RAY 1b6c D Reference
       Region 1b6c D 162-174 disorder
       Region 1b6c D 175-500 order
       Region 1b6c D 501-503 disorder
 Evidence X-RAY 1b6c F Reference
       Region 1b6c F 162-174 disorder
       Region 1b6c F 175-500 order
       Region 1b6c F 501-503 disorder
 Evidence X-RAY 1b6c H Reference
       Region 1b6c H 162-174 disorder
       Region 1b6c H 175-500 order
       Region 1b6c H 501-503 disorder
SeqProS verified 175-199 Hetero dimer : P62942
       Region 1b6c B 175-500 order
       Region 1b6c D 175-500 order
       Region 1b6c F 175-500 order
       Region 1b6c H 175-500 order
       Region 1py5 A 175-199 disorder
SeqProS verified 175-199 This region is ordered when interacts with another chain of this protein. Homo pentamer :
       Region 1ias A 171-500 order
       Region 1ias B 171-320 order
       Region 1ias C 171-500 order
       Region 1ias D 171-500 order
       Region 1ias E 171-500 order
       Region 3faa A 171-367 order
       Region 3faa B 171-320 order
       Region 3faa C 171-500 order
       Region 3faa D 171-500 order
       Region 3faa E 171-500 order
       Region 1py5 A 175-199 disorder
SeqProS verified 175-199 This region is ordered when interacts with another chain of this protein. :
       Region 2x7o A 171-500 order
       Region 2x7o B 171-500 order
       Region 2x7o C 162-170 disorder
       Region 2x7o D 171-500 order
       Region 2x7o E 171-500 order
       Region 3kcf A 171-367 order
       Region 3kcf B 171-320 order
       Region 3kcf C 171-500 order
       Region 3kcf D 171-500 order
       Region 3kcf E 171-500 order
       Region 1py5 A 175-199 disorder
Seqphosphorylation
    165-165 Phosphoserine
    185-185 Phosphothreonine; by TGFBR2
    186-186 Phosphothreonine; by TGFBR2
    187-187 Phosphoserine; by TGFBR2
    189-189 Phosphoserine; by TGFBR2
    191-191 Phosphoserine; by TGFBR2
 
Prediction
DICHOT
Disorder 1-11,112-125,149-199,501-503
Known Domain 12-111,126-148,200-500
SCOPe RPS-Blast
     1rewC 33-113 1e-13 g.7.1.3 BMP receptor Ia ectodomain
     3tzmA 200-496 e-131 d.144.1.7 3-phosphoinositide dependent protein ...
SCOP Hmmer
     1es7B_ 32-111 3e-13 g.7.1.3 BMP receptor Ia ect...
     1b6cB_ 180-492 2e-72 d.144.1.7 3-phosphoinositi...
Pfam RPS-Blast
     PF01064 35-108 2e-06 Activin types I and II recep...
     PF08515 176-203 1e-06 Transforming growth factor ...
Pfam Hmmer
    PF01064 34-109 1.9e-12 Activin types I and II rece...
    PF08515 176-203 1.3e-20 Transforming growth factor...
    PF00069 208-489 1.6e-39 Protein kinase domain