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IID00433  Forkhead box protein O3 (Homo sapiens) O43524
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
673
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 151-253 Monomer :
 Evidence X-RAY 2uzk A Reference
       Region 2uzk A 158-253 order
 Evidence X-RAY 2uzk C Reference
       Region 2uzk C 158-247 order
       Region 2uzk C 248-253 disorder
 Evidence NMR 2k86 A Reference
       Region 2k86 A 151-251 order
       Region 2k86 A 151-151 high_rmsd
       Region 2k86 A 228-229 high_rmsd
       Region 2k86 A 247-251 high_rmsd
Seq 461-483,618-635 Hetero dimer : IID50008Complex
 Evidence NMR 2lqh B This region is the chimera protein. Reference
       Region 2lqh B 461-483 order
       Region 2lqh B 461-464 high_rmsd
       Region 2lqh B 483-483 high_rmsd
       Region 2lqh B 618-635 order
 Evidence NMR 2lqi B This region is the chimera protein. Reference
       Region 2lqi B 461-483 order
       Region 2lqi B 461-464 high_rmsd
       Region 2lqi B 482-483 high_rmsd
       Region 2lqi B 618-635 order
Seqdisorder 461-483,618-635
 Evidence CD Reference
       Region 461-483 disorder
       Region 618-635 disorder
SeqProS verified 466-481,623-634 Hetero dimer : IID50008Complex
       Region 2lqh B 461-483 order
       Region 2lqi B 461-483 order
       Region 2lqh B 618-635 order
       Region 2lqi B 618-635 order
       Region 461-483 disorder
       Region 618-635 disorder
Seqphosphorylation
    32-32 Phosphothreonine; by PKB/AKT1
    179-179 Phosphothreonine; by AMPK
    209-209 Phosphoserine; by STK4/MST1
    215-215 Phosphoserine; by MAPKAPK5
    253-253 Phosphoserine; by PKB/AKT1 and MAPKAPK5
    280-280 Phosphoserine
    284-284 Phosphoserine
    294-294 Phosphoserine
    299-299 Phosphoserine; by CaMK2A
    311-311 Phosphoserine
    315-315 Phosphoserine; by SGK1
    399-399 Phosphoserine; by AMPK
    413-413 Phosphoserine; by AMPK
    421-421 Phosphoserine
    551-551 Phosphoserine; by MAPKAPK5
    555-555 Phosphoserine; by AMPK and MAPKAPK5
    588-588 Phosphoserine; by AMPK
    626-626 Phosphoserine; by AMPK
    644-644 Phosphoserine; by IKKB
Seqacetylation
    242-242 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-157,254-673
Known Domain 158-253
SCOPe RPS-Blast
     3l2cA 153-237 5e-43 a.4.5.14 Adipocyte-transcription factor FREAC-1...
SCOP Hmmer
     1e17A_ 153-239 2.1e-34 a.4.5.14 Adipocyte-trans...
Pfam RPS-Blast
     PF00250 159-239 7e-08 Forkhead domain
     PF16675 433-505 3e-10 KIX-binding domain of forkh...
     PF16676 605-644 2e-13 Transactivation domain of F...
Pfam Hmmer
    PF00250 159-240 2.1e-29 Forkhead domain
    PF16675 433-511 2.4e-37 KIX-binding domain of fork...
    PF16676 604-644 1.9e-25 Transactivation domain of ...