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IID00443  Interferon-induced, double-stranded RNA-activated protein kinase (Homo sapiens) P19525
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
551
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-170 Monomer :
 Evidence NMR 1qu6 A Reference
       Region 1qu6 A 1-170 order
       Region 1qu6 A 5-6 high_rmsd
       Region 1qu6 A 33-38 high_rmsd
       Region 1qu6 A 79-100 high_rmsd
       Region 1qu6 A 107-113 high_rmsd
       Region 1qu6 A 123-130 high_rmsd
       Region 1qu6 A 167-170 high_rmsd
Seq 254-551 Monomer :
 Evidence X-RAY 3uiu A Reference
       Region 3uiu A 254-336 order
       Region 3uiu A 337-354 disorder
       Region 3uiu A 355-439 order
       Region 3uiu A 440-450 disorder
       Region 3uiu A 451-460 order
       Region 3uiu A 461-464 disorder
       Region 3uiu A 465-541 order
       Region 3uiu A 542-551 disorder
 Evidence X-RAY 3uiu B Reference
       Region 3uiu B 254-336 order
       Region 3uiu B 337-354 disorder
       Region 3uiu B 355-439 order
       Region 3uiu B 440-450 disorder
       Region 3uiu B 451-460 order
       Region 3uiu B 461-464 disorder
       Region 3uiu B 465-541 order
       Region 3uiu B 542-551 disorder
Seq 258-550 Hetero trimer : IID50184Complex
 Evidence X-RAY 2a19 B Reference
       Region 2a19 B 258-333 order
       Region 2a19 B 334-337 disorder
       Region 2a19 B 338-350 order
       Region 2a19 B 351-355 disorder
       Region 2a19 B 356-541 order
       Region 2a19 B 542-550 disorder
 Evidence X-RAY 2a19 C Reference
       Region 2a19 C 258-350 order
       Region 2a19 C 351-357 disorder
       Region 2a19 C 358-374 order
       Region 2a19 C 375-389 disorder
       Region 2a19 C 390-436 order
       Region 2a19 C 437-465 disorder
       Region 2a19 C 466-482 order
       Region 2a19 C 483-500 disorder
       Region 2a19 C 501-541 order
       Region 2a19 C 542-550 disorder
Seq 258-550 Hetero tetramer : IID50184Complex
 Evidence X-RAY 2a1a B Reference
       Region 2a1a B 258-350 order
       Region 2a1a B 351-354 disorder
       Region 2a1a B 355-541 order
       Region 2a1a B 542-550 disorder
Seqphosphorylation
    83-83 Phosphoserine
    88-88 Phosphothreonine; by autocatalysis
    89-89 Phosphothreonine; by autocatalysis
    90-90 Phosphothreonine; by autocatalysis
    101-101 Phosphotyrosine; by autocatalysis
    162-162 Phosphotyrosine; by autocatalysis
    242-242 Phosphoserine; by autocatalysis
    255-255 Phosphothreonine; by autocatalysis
    258-258 Phosphothreonine; by autocatalysis
    293-293 Phosphotyrosine; by autocatalysis
    446-446 Phosphothreonine; by autocatalysis
    451-451 Phosphothreonine; by autocatalysis
    456-456 Phosphoserine
    542-542 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
DICHOT
Disorder 171-256,542-551
Known Domain 1-170,257-541
SCOPe RPS-Blast
     1x49A1 1-83 8e-25 d.50.1.1 ATP-dependent RNA helicase A, Dhx9
     1x48A1 101-173 1e-19 d.50.1.1 ATP-dependent RNA helicase A, Dhx9
     2a19B1 258-541 e-115 d.144.1.0 automated matches
SCOP Hmmer
     1qu6A1 11-79 5.8e-22 d.50.1.1 ATP-dependent RNA...
     1qu6A2 88-167 8.9e-19 d.50.1.1 ATP-dependent RN...
     1kwpA_ 259-536 2.2e-67 d.144.1.7 3-phosphoinosi...
Pfam RPS-Blast
     PF00035 13-75 8e-11 Double-stranded RNA binding m...
     PF00035 102-164 1e-05 Double-stranded RNA binding...
     PF06293 363-434 4e-06 Lipopolysaccharide kinase (...
     PF14531 411-484 4e-04 Kinase-like
Pfam Hmmer
    PF00035 13-75 7.8e-18 Double-stranded RNA binding ...
    PF00035 101-164 1.4e-15 Double-stranded RNA bindin...
    PF00069 267-534 7.2e-58 Protein kinase domain