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IID00463  Neurogenic locus notch homolog protein 2 (Homo sapiens) Q04721
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
xml
Experiment
2471
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 414-532 Monomer :
 Evidence X-RAY 5mwb A Reference
       Region 5mwb A 414-414 disorder
       Region 5mwb A 415-532 order
Seq 1423-1677 Monomer :
 Evidence X-RAY 2oo4 A Reference
       Region 2oo4 A 1423-1424 disorder
       Region 2oo4 A 1425-1672 order
       Region 2oo4 A 1673-1677 disorder
 Evidence X-RAY 2oo4 B Reference
       Region 2oo4 B 1423-1424 disorder
       Region 2oo4 B 1425-1672 order
       Region 2oo4 B 1673-1677 disorder
Seqphosphorylation
    1716-1716 Phosphothreonine
    1778-1778 Phosphoserine
    1802-1802 Phosphothreonine
    1804-1804 Phosphoserine
    1808-1808 Phosphothreonine
    1842-1842 Phosphoserine
    1845-1845 Phosphoserine
    2070-2070 Phosphoserine
    2078-2078 Phosphoserine
    2081-2081 Phosphoserine
    2097-2097 Phosphothreonine
 
Prediction
DICHOT
Disorder 1-52,413-414,835-853,1101-1119,1673-1677,1701-1871,2064-2471
Known Domain 53-412,415-834,854-1100,1120-1672,1678-1700,1872-2063
SCOPe RPS-Blast
     1egfA 66-104 3e-05 g.3.11.1 Activated protein c (autoprothrombin IIa...
     1g1tA2 145-183 9e-07 g.3.11.1 Activated protein c (autoprothrombin I...
     5mwbA1 182-218 2e-08 g.3.11.0 automated matches
     1g1tA2 225-261 3e-04 g.3.11.1 Activated protein c (autoprothrombin I...
     1edmB 260-295 2e-07 g.3.11.1 Activated protein c (autoprothrombin II...
     5mwbA1 298-338 7e-07 g.3.11.0 automated matches
     5mwbA1 415-456 2e-11 g.3.11.0 automated matches
     1edmB 456-493 6e-10 g.3.11.1 Activated protein c (autoprothrombin II...
     1edmB 494-531 1e-10 g.3.11.1 Activated protein c (autoprothrombin II...
     1edmB 531-568 4e-10 g.3.11.1 Activated protein c (autoprothrombin II...
     1autL1 566-609 7e-09 g.3.11.1 Activated protein c (autoprothrombin I...
     1edmB 608-644 3e-10 g.3.11.1 Activated protein c (autoprothrombin II...
     1autL1 642-684 1e-11 g.3.11.1 Activated protein c (autoprothrombin I...
     1edmB 681-711 4e-08 g.3.11.1 Activated protein c (autoprothrombin II...
     1autL1 716-759 1e-07 g.3.11.1 Activated protein c (autoprothrombin I...
     5mwbA1 757-795 2e-08 g.3.11.0 automated matches
     1edmB 794-832 3e-11 g.3.11.1 Activated protein c (autoprothrombin II...
     1g1tA2 835-874 3e-04 g.3.11.1 Activated protein c (autoprothrombin I...
     5mwbA1 873-911 2e-08 g.3.11.0 automated matches
     1edmB 911-948 9e-11 g.3.11.1 Activated protein c (autoprothrombin II...
     1edmB 948-985 4e-11 g.3.11.1 Activated protein c (autoprothrombin II...
     1edmB 987-1022 6e-09 g.3.11.1 Activated protein c (autoprothrombin I...
     1edmB 1025-1062 3e-11 g.3.11.1 Activated protein c (autoprothrombin ...
     1edmB 1151-1185 9e-11 g.3.11.1 Activated protein c (autoprothrombin ...
     1edmB 1187-1223 5e-09 g.3.11.1 Activated protein c (autoprothrombin ...
     1edmB 1225-1262 2e-07 g.3.11.1 Activated protein c (autoprothrombin ...
     1edmB 1264-1303 3e-05 g.3.11.1 Activated protein c (autoprothrombin ...
     5mwbA1 1312-1343 1e-04 g.3.11.0 automated matches
     1egfA 1378-1412 6e-04 g.3.11.1 Activated protein c (autoprothrombin ...
     1pb5A 1424-1456 4e-06 g.65.1.1 Neurogenic locus notch homolog protei...
     2f8yA 1858-2071 1e-82 d.211.1.1 26S proteasome non-ATPase regulator...
SCOP Hmmer
     1haeA_ 27-64 1.1e-06 g.3.11.1 Activated protein...
     1gk5A_ 65-105 6.1e-10 g.3.11.1 Activated protei...
     1p9jA_ 108-144 7.5e-09 g.3.11.1 Activated prote...
     1ffmA_ 146-187 1.4e-11 g.3.11.1 Activated prote...
     1uzpA2 181-219 5.2e-10 g.3.11.1 Activated prote...
     1haeA_ 222-264 1.1e-09 g.3.11.1 Activated prote...
     1haeA_ 260-307 2e-12 g.3.11.1 Activated protein...
     1tozA1 298-336 1.5e-10 g.3.11.1 Activated prote...
     2dtgE6 325-461 2.9e-12 g.3.9.1 EGF receptor Cys...
     2dtgE6 413-536 2.3e-14 g.3.9.1 EGF receptor Cys...
     2dtgE6 529-643 1.3e-12 g.3.9.1 EGF receptor Cys...
     2dtgE6 594-725 1.7e-14 g.3.9.1 EGF receptor Cys...
     2dtgE6 669-799 4.2e-14 g.3.9.1 EGF receptor Cys...
     2dtgE6 782-915 1.8e-14 g.3.9.1 EGF receptor Cys...
     1ffmA_ 911-954 1.4e-14 g.3.11.1 Activated prote...
     1ffmA_ 948-991 1e-13 g.3.11.1 Activated protein...
     1dvaL1 983-1026 5.2e-11 g.3.11.1 Activated prot...
     2dtgE6 1013-1153 1.1e-13 g.3.9.1 EGF receptor C...
     1ffmA_ 1149-1191 3e-13 g.3.11.1 Activated prote...
     2dtgE6 1174-1308 2.5e-14 g.3.9.1 EGF receptor C...
     1haeA_ 1305-1344 2.3e-09 g.3.11.1 Activated pro...
     1egfA_ 1377-1415 2.5e-09 g.3.11.1 Activated pro...
     1pb5A_ 1424-1456 3.4e-09 g.65.1.1 Neurogenic lo...
     1pb5A_ 1466-1497 4.5e-05 g.65.1.1 Neurogenic lo...
     1pb5A_ 1503-1534 1.1e-08 g.65.1.1 Neurogenic lo...
     1s70B_ 1820-2066 7.9e-54 d.211.1.1 26S proteaso...
Pfam RPS-Blast
     PF00008 264-292 7e-04 EGF-like domain
     PF00008 460-490 4e-04 EGF-like domain
     PF00008 498-527 5e-05 EGF-like domain
     PF00008 536-564 5e-05 EGF-like domain
     PF00008 761-789 4e-05 EGF-like domain
     PF00008 799-829 4e-05 EGF-like domain
     PF00012 829-1373 3e-05 Hsp70 protein
     PF00066 1427-1455 5e-04 LNR domain
     PF00066 1501-1535 1e-04 LNR domain
     PF06816 1539-1594 1e-22 NOTCH protein
     PF07684 1620-1673 2e-12 NOTCH protein
     PF13857 1867-1915 2e-09 Ankyrin repeats (many cop...
     PF13857 1896-1951 3e-07 Ankyrin repeats (many cop...
     PF13857 1963-2017 1e-09 Ankyrin repeats (many cop...
     PF11936 2382-2443 2e-17 Domain of unknown functio...
Pfam Hmmer
    PF00008 68-99 1.3e-09 EGF-like domain
    PF00008 113-140 1.2e-10 EGF-like domain
    PF00008 148-177 4.8e-08 EGF-like domain
    PF07645 182-214 8.1e-12 Calcium-binding EGF domain
    PF12661 230-252 1.6e-05 Human growth factor-like E...
    PF00008 264-292 1.1e-08 EGF-like domain
    PF07645 298-331 4.1e-11 Calcium-binding EGF domain
    PF12661 347-367 2.2e-05 Human growth factor-like E...
    PF00008 379-410 2.4e-08 EGF-like domain
    PF07645 415-449 2.1e-11 Calcium-binding EGF domain
    PF00008 460-489 3.3e-10 EGF-like domain
    PF00008 498-527 1e-10 EGF-like domain
    PF00008 536-564 2e-12 EGF-like domain
    PF12661 579-599 4.6e-08 Human growth factor-like E...
    PF00008 611-639 1.9e-09 EGF-like domain
    PF00008 649-678 1.5e-10 EGF-like domain
    PF00008 686-711 3.1e-08 EGF-like domain
    PF00008 761-789 3.6e-10 EGF-like domain
    PF00008 799-829 1.9e-11 EGF-like domain
    PF00008 837-869 1.8e-10 EGF-like domain
    PF07645 873-904 6.5e-11 Calcium-binding EGF domain
    PF00008 915-944 1.3e-11 EGF-like domain
    PF00008 953-982 2e-10 EGF-like domain
    PF00008 991-1020 3.4e-10 EGF-like domain
    PF00008 1029-1059 9.4e-13 EGF-like domain
    PF00008 1067-1097 3.2e-08 EGF-like domain
    PF00008 1120-1145 9.4e-09 EGF-like domain
    PF00008 1153-1182 9.4e-11 EGF-like domain
    PF00008 1191-1219 4.4e-10 EGF-like domain
    PF00008 1229-1260 2.5e-10 EGF-like domain
    PF00008 1308-1341 1.2e-10 EGF-like domain
    PF00066 1423-1456 2.8e-14 LNR domain
    PF00066 1463-1497 9e-11 LNR domain
    PF00066 1501-1534 1.2e-14 LNR domain
    PF06816 1539-1594 2e-28 NOTCH protein
    PF07684 1618-1671 2.9e-20 NOTCH protein
    PF00023 1827-1874 1.2e-08 Ankyrin repeat
    PF12796 1881-1974 4.5e-13 Ankyrin repeats (3 copie...
    PF12796 1948-2039 2.3e-15 Ankyrin repeats (3 copie...
    PF11936 2382-2444 5.1e-30 Domain of unknown functi...