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IID00511  SHC-transforming protein 1 (Homo sapiens) P29353
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
583
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 111-317 Monomer :
 Evidence NMR 1n3h A Reference
       Region 1n3h A 111-189 order
       Region 1n3h A 190-221 disorder
       Region 1n3h A 222-285 order
       Region 1n3h A 286-292 disorder
       Region 1n3h A 293-317 order
 Evidence NMR 1oy2 A Reference
       Region 1oy2 A 111-126 disorder
       Region 1oy2 A 127-189 order
       Region 1oy2 A 190-221 disorder
       Region 1oy2 A 222-285 order
       Region 1oy2 A 286-292 disorder
       Region 1oy2 A 293-317 order
 Evidence X-RAY 4xwx A Reference
       Region 4xwx A 147-205 order
       Region 4xwx A 206-212 disorder
       Region 4xwx A 213-311 order
Seq 127-317 Hetero dimer : P05106
 Evidence NMR 2l1c A Reference
       Region 2l1c A 127-317 order
       Region 2l1c A 127-142 high_rmsd
Seq 127-317 Hetero dimer : IID00535Complex
 Evidence NMR 1shc A Reference
       Region 1shc A 127-317 order
Seq 344-356 Hetero dimer :
 Evidence X-RAY 4jmh B This region binds to Grb2 fusioned with FN3. Reference
       Region 4jmh B 344-346 disorder
       Region 4jmh B 347-354 order
       Region 4jmh B 355-356 disorder
Seq 345-353 Hetero dimer : IID00262Complex
 Evidence X-RAY 5czi B Reference
       Region 5czi B 345-345 disorder
       Region 5czi B 346-352 order
       Region 5czi B 353-353 disorder
Seq 423-435 Hetero dimer : IID00459Complex
 Evidence NMR 1qg1 I Reference
       Region 1qg1 I 423-435 order
Seq 480-583 Hetero dimer : IID00544Complex
 Evidence NMR 1tce A Reference
       Region 1tce A 480-583 order
Seq 482-583 Monomer :
 Evidence X-RAY 1mil A Reference
       Region 1mil A 482-583 order
SeqProS verified 190-221,286-292 Hetero dimer : IID00535Complex
       Region 1shc A 127-317 order
       Region 1n3h A 190-221 disorder
       Region 1oy2 A 190-221 disorder
       Region 1n3h A 286-292 disorder
       Region 1oy2 A 286-292 disorder
SeqProS predicted 423-435 The unbound state of this region is deduced to be disordered based on the results of prediction tools (DICHOT, Mobi, d2p2 etc). Hetero dimer : IID00459Complex
       Region 1qg1 I 423-435 order
Seqphosphorylation
    36-36 Phosphoserine
    139-139 Phosphoserine
    349-349 Phosphotyrosine
    350-350 Phosphotyrosine
    427-427 Phosphotyrosine
    453-453 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
    154-154 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-146,312-481
Known Domain 147-311,482-583
SCOPe RPS-Blast
     1n3hA 111-317 6e-64 b.55.1.2 Amyloid beta A4 precursor protein-bindi...
     1milA 480-583 1e-45 d.93.1.1 Abl tyrosine kinase
SCOP Hmmer
     1shcA_ 128-317 1.4e-66 b.55.1.2 Amyloid beta A4...
     1xa6A2 471-576 1.7e-29 d.93.1.1 Abl tyrosine ki...
Pfam RPS-Blast
     PF00017 488-559 9e-06 SH2 domain
Pfam Hmmer
    PF00640 162-317 6.5e-51 Phosphotyrosine interactio...
    PF00017 488-559 3e-21 SH2 domain