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IID00513  Disks large homolog 1 (Homo sapiens) Q12959
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
904
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-65 Hetero trimer : IID00515Complex,IID00521Complex
 Evidence X-RAY 3lra A Reference
       Region 3lra A 2-65 order
Seq 220-317 Hetero dimer : IID00035Complex
 Evidence X-RAY 3rl7 A Reference
       Region 3rl7 A 220-309 order
       Region 3rl7 A 310-317 disorder
 Evidence X-RAY 3rl7 B Reference
       Region 3rl7 B 220-246 order
       Region 3rl7 B 247-249 disorder
       Region 3rl7 B 250-310 order
       Region 3rl7 B 311-317 disorder
 Evidence X-RAY 3rl7 C Reference
       Region 3rl7 C 220-245 order
       Region 3rl7 C 246-249 disorder
       Region 3rl7 C 250-310 order
       Region 3rl7 C 311-317 disorder
 Evidence X-RAY 3rl7 D Reference
       Region 3rl7 D 220-310 order
       Region 3rl7 D 311-317 disorder
 Evidence X-RAY 3rl7 E Reference
       Region 3rl7 E 220-241 order
       Region 3rl7 E 242-250 disorder
       Region 3rl7 E 251-310 order
       Region 3rl7 E 311-317 disorder
 Evidence X-RAY 3rl7 F Reference
       Region 3rl7 F 220-309 order
       Region 3rl7 F 310-317 disorder
Seq 310-407 Hetero dimer : IID00035Complex
 Evidence X-RAY 4g69 A Reference
       Region 4g69 A 310-406 order
       Region 4g69 A 407-407 disorder
Seq 311-407 Homo dimer :
 Evidence X-RAY 4amh A Reference
       Region 4amh A 315-319 disorder
       Region 4amh A 320-323 order
       Region 4amh A 324-325 disorder
       Region 4amh A 326-405 order
 Evidence X-RAY 4amh B Reference
       Region 4amh B 315-319 disorder
       Region 4amh B 320-323 order
       Region 4amh B 324-326 disorder
       Region 4amh B 327-405 order
 Evidence X-RAY 2x7z A Reference
       Region 2x7z A 311-407 order
Seq 315-410 Hetero hexamer : IID00035Complex
 Evidence X-RAY 3rl8 A Reference
       Region 3rl8 A 315-315 disorder
       Region 3rl8 A 316-409 order
       Region 3rl8 A 410-410 disorder
 Evidence X-RAY 3rl8 B Reference
       Region 3rl8 B 315-315 disorder
       Region 3rl8 B 316-405 order
       Region 3rl8 B 406-410 disorder
 Evidence X-RAY 3rl8 C Reference
       Region 3rl8 C 315-315 disorder
       Region 3rl8 C 316-410 order
 Evidence X-RAY 3rl8 D Reference
       Region 3rl8 D 315-315 disorder
       Region 3rl8 D 316-409 order
       Region 3rl8 D 410-410 disorder
 Evidence X-RAY 3rl8 E Reference
       Region 3rl8 E 315-315 disorder
       Region 3rl8 E 316-405 order
       Region 3rl8 E 406-410 disorder
Seq 318-406 Hetero dimer : IID90014Complex
 Evidence NMR 2m3m A Reference
       Region 2m3m A 318-406 order
Seq 318-406 Hetero dimer :
 Evidence NMR 2oqs A This region binds to HPV-18 E6 protein. Reference
       Region 2oqs A 318-406 order
Seq 457-555 Homo hexamer :
 Evidence X-RAY 1pdr A Reference
       Region 1pdr A 457-459 disorder
       Region 1pdr A 460-555 order
Seq 712-904 Monomer :
 Evidence X-RAY 3w9y A Reference
       Region 3w9y A 712-835 order
       Region 3w9y A 836-853 disorder
       Region 3w9y A 854-904 order
Seqphosphorylation
    115-115 Phosphothreonine
    122-122 Phosphoserine
    138-138 Phosphoserine
    158-158 Phosphoserine
    232-232 Phosphoserine
    399-399 Phosphotyrosine
    568-568 Phosphoserine
    573-573 Phosphoserine
    575-575 Phosphoserine
    579-579 Phosphoserine
    598-598 Phosphoserine
    619-619 Phosphoserine
    684-684 Phosphoserine
    687-687 Phosphoserine
    834-834 Phosphoserine
 
Prediction
DICHOT
Disorder 1-1,66-220,408-459,556-582,902-904
Known Domain 2-65,221-407,460-555,583-901
SCOPe RPS-Blast
     1rsoA 4-63 9e-24 a.194.1.1 Associated tight junction protein Pals-1
     2fe5A1 223-309 3e-37 b.36.1.1 Afadin
     2fe5A1 317-407 7e-43 b.36.1.1 Afadin
     2he2A1 463-558 7e-45 b.36.1.1 Afadin
     1kjwA1 584-669 2e-30 b.34.2.1 53BP2
     1kjwA2 706-904 7e-86 c.37.1.1 5' polynucleotide kinase-3' phosphatas...
SCOP Hmmer
     1rsoA_ 4-63 3.4e-23 a.194.1.1 Associated tight ...
     1wg6A_ 206-312 3.2e-30 PDZ domain-like
     1wg6A_ 314-407 9.3e-28 PDZ domain-like
     1uitA_ 456-553 8.2e-32 PDZ domain-like
     1vyvA1 556-740 6.2e-34 b.34.2.1 53BP2
     1kjwA2 712-901 3.1e-63 c.37.1.1 5' polynucleoti...
Pfam RPS-Blast
     PF09058 2-62 3e-24 L27_1
     PF10608 185-223 1e-09 Polyubiquitination (PEST) N...
     PF00595 230-307 8e-10 PDZ domain
     PF00595 330-402 4e-09 PDZ domain
     PF10600 404-465 2e-16 PDZ-associated domain of NM...
     PF00595 469-542 1e-09 PDZ domain
     PF00625 713-890 8e-10 Guanylate kinase
Pfam Hmmer
    PF09058 2-62 3.3e-34 L27_1
    PF10608 106-223 1.6e-63 Polyubiquitination (PEST) ...
    PF00595 224-307 2.2e-23 PDZ domain
    PF00595 320-402 1.7e-23 PDZ domain
    PF10600 404-465 1.9e-27 PDZ-associated domain of N...
    PF00595 467-542 1.2e-22 PDZ domain
    PF00018 587-643 3.5e-11 SH3 domain
    PF00625 714-890 7.7e-70 Guanylate kinase