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IID00536  Heat shock protein HSP 90-beta (Homo sapiens) P08238
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
724
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-218 Homo tetramer :
 Evidence X-RAY 5uc4 A Reference
       Region 5uc4 A 1-217 order
       Region 5uc4 A 218-218 disorder
 Evidence X-RAY 5uc4 B Reference
       Region 5uc4 B 1-8 disorder
       Region 5uc4 B 9-217 order
       Region 5uc4 B 218-218 disorder
 Evidence X-RAY 5uc4 C Reference
       Region 5uc4 C 1-217 order
       Region 5uc4 C 218-218 disorder
 Evidence X-RAY 5uc4 D Reference
       Region 5uc4 D 1-8 disorder
       Region 5uc4 D 9-217 order
       Region 5uc4 D 218-218 disorder
Seq 1-223 Monomer :
 Evidence X-RAY 3nmq A Reference
       Region 3nmq A 1-7 disorder
       Region 3nmq A 8-221 order
       Region 3nmq A 222-223 disorder
 Evidence X-RAY 5uch A Reference
       Region 5uch A 1-217 order
       Region 5uch A 218-218 disorder
 Evidence X-RAY 5uch B Reference
       Region 5uch B 1-9 disorder
       Region 5uch B 10-217 order
       Region 5uch B 218-218 disorder
 Evidence X-RAY 5uch C Reference
       Region 5uch C 1-217 order
       Region 5uch C 218-218 disorder
 Evidence X-RAY 5uch D Reference
       Region 5uch D 1-10 disorder
       Region 5uch D 11-217 order
       Region 5uch D 218-218 disorder
 Evidence X-RAY 5uci A Reference
       Region 5uci A 1-217 order
       Region 5uci A 218-218 disorder
 Evidence X-RAY 5uci B Reference
       Region 5uci B 1-9 disorder
       Region 5uci B 10-217 order
       Region 5uci B 218-218 disorder
 Evidence X-RAY 5uci C Reference
       Region 5uci C 1-8 order
       Region 5uci C 9-9 disorder
       Region 5uci C 10-217 order
       Region 5uci C 218-218 disorder
 Evidence X-RAY 5uci D Reference
       Region 5uci D 1-9 disorder
       Region 5uci D 10-217 order
       Region 5uci D 218-218 disorder
 Evidence X-RAY 5ucj A Reference
       Region 5ucj A 1-217 order
       Region 5ucj A 218-218 disorder
 Evidence X-RAY 5ucj B Reference
       Region 5ucj B 1-217 order
       Region 5ucj B 218-218 disorder
 Evidence X-RAY 5ucj C Reference
       Region 5ucj C 1-9 disorder
       Region 5ucj C 10-217 order
       Region 5ucj C 218-218 disorder
 Evidence X-RAY 5ucj D Reference
       Region 5ucj D 1-9 disorder
       Region 5ucj D 10-217 order
       Region 5ucj D 218-218 disorder
 Evidence X-RAY 1uym A Reference
       Region 1uym A 2-10 disorder
       Region 1uym A 11-220 order
       Region 1uym A 221-221 disorder
Seq 284-543 Homo trimer :
 Evidence X-RAY 3pry A Reference
       Region 3pry A 284-341 order
       Region 3pry A 342-349 disorder
       Region 3pry A 350-543 order
 Evidence X-RAY 3pry B Reference
       Region 3pry B 284-340 order
       Region 3pry B 341-350 disorder
       Region 3pry B 351-389 order
       Region 3pry B 390-392 disorder
       Region 3pry B 393-543 order
 Evidence X-RAY 3pry C Reference
       Region 3pry C 284-284 disorder
       Region 3pry C 285-340 order
       Region 3pry C 341-351 disorder
       Region 3pry C 352-543 order
Seq 719-723 Hetero tetramer : IID00449Complex
 Evidence X-RAY 3fwv C Reference
       Region 3fwv C 719-723 order
 Evidence X-RAY 3fwv D Reference
       Region 3fwv D 719-723 order
Seq 720-724 Hetero pentamer : IID00068Complex
 Evidence X-RAY 1qz2 G Reference
       Region 1qz2 G 720-724 order
 Evidence X-RAY 1qz2 H Reference
       Region 1qz2 H 720-724 order
Seq 720-724 Hetero dimer : IID50204Complex
 Evidence NMR 2l6j B Reference
       Region 2l6j B 720-724 order
Seq 720-724 Hetero trimer : IID50201Complex
 Evidence X-RAY 3uq3 B Reference
       Region 3uq3 B 720-724 order
 Evidence X-RAY 3uq3 C Reference
       Region 3uq3 C 720-721 disorder
       Region 3uq3 C 722-724 order
SeqProS possible 719-723 This region is described to be disordered in the free state (PubMed=22227520). Hetero tetramer : IID00449Complex
       Region 3fwv C 719-723 order
       Region 3fwv D 719-723 order
SeqProS possible 720-724 This region is described to be disordered in the free state (PubMed=22227520). Hetero dimer : IID50204Complex
       Region 2l6j B 720-724 order
SeqProS possible 720-724 This region is described to be disordered in the free state (PubMed=22227520). Hetero trimer : IID50201Complex
       Region 3uq3 B 720-724 order
       Region 3uq3 C 722-724 order
SeqProS possible 720-724 This region is described to be disordered in the free state (PubMed=22227520). Hetero pentamer : IID00068Complex
       Region 1qz2 G 720-724 order
       Region 1qz2 H 720-724 order
Seqphosphorylation
    226-226 Phosphoserine
    255-255 Phosphoserine
    261-261 Phosphoserine
    297-297 Phosphothreonine
    301-301 Phosphotyrosine; by SRC
    305-305 Phosphotyrosine
    307-307 Phosphoserine
    445-445 Phosphoserine
    479-479 Phosphothreonine
    484-484 Phosphotyrosine
    669-669 Phosphoserine
    718-718 Phosphoserine; by PLK2 and PLK3
Seqacetylation
    435-435 N6-acetyllysine
    481-481 N6-acetyllysine
    624-624 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-13,220-285,690-724
Known Domain 14-219,286-689
SCOPe RPS-Blast
     3t0hA 11-219 9e-67 d.122.1.1 HSP90
     1y6zA 287-538 5e-67 d.14.1.0 automated matches
     1sf8A1 563-684 8e-28 d.271.1.1 Chaperone protein HtpG
SCOP Hmmer
     2iwxA1 12-221 1.6e-75 ATPase domain of HSP90 c...
     1usuA_ 284-539 2e-115 d.14.1.8 Heat shock prote...
     1sf8A_ 562-684 5.2e-43 HSP90 C-terminal domain
Pfam RPS-Blast
     PF13589 33-158 2e-09 Histidine kinase-, DNA gyras...
     PF00183 404-707 1e-29 Hsp90 protein
Pfam Hmmer
    PF02518 35-188 2.9e-17 Histidine kinase-, DNA gyra...
    PF00183 191-703 1.5e-239 Hsp90 protein