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IID00561  Amyloid-beta A4 precursor protein-binding family A member 1 (Homo sapiens) Q02410
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
837
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 453-623 Hetero tetramer :
 Evidence X-RAY 1aqc A Reference
       Region 1aqc A 453-499 order
       Region 1aqc A 500-513 disorder
       Region 1aqc A 514-562 order
       Region 1aqc A 563-584 disorder
       Region 1aqc A 585-617 order
       Region 1aqc A 618-623 disorder
 Evidence X-RAY 1aqc B Reference
       Region 1aqc B 453-458 disorder
       Region 1aqc B 459-472 order
       Region 1aqc B 473-479 disorder
       Region 1aqc B 480-500 order
       Region 1aqc B 501-514 disorder
       Region 1aqc B 515-562 order
       Region 1aqc B 563-584 disorder
       Region 1aqc B 585-623 order
Seq 453-623 Hetero tetramer : IID00294Complex
 Evidence X-RAY 1x11 A Reference
       Region 1x11 A 453-497 order
       Region 1x11 A 498-513 disorder
       Region 1x11 A 514-560 order
       Region 1x11 A 561-579 disorder
       Region 1x11 A 580-621 order
       Region 1x11 A 622-623 disorder
 Evidence X-RAY 1x11 B Reference
       Region 1x11 B 453-458 disorder
       Region 1x11 B 459-472 order
       Region 1x11 B 473-480 disorder
       Region 1x11 B 481-502 order
       Region 1x11 B 503-513 disorder
       Region 1x11 B 514-560 order
       Region 1x11 B 561-584 disorder
       Region 1x11 B 585-623 order
Seq 655-741 Monomer :
 Evidence NMR 1u37 A Reference
       Region 1u37 A 655-741 order
 Evidence NMR 1x45 A Reference
       Region 1x45 A 656-740 order
Seq 655-741 Hetero dimer :
 Evidence NMR 1u38 A Reference
       Region 1u38 A 655-741 order
Seq 655-837 Monomer :
 Evidence NMR 1u3b A Reference
       Region 1u3b A 655-837 order
Seq 743-823 Monomer :
 Evidence NMR 1u39 A Reference
       Region 1u39 A 743-822 order
 Evidence NMR 1y7n A Reference
       Region 1y7n A 745-823 order
Seqphosphorylation
    78-78 Phosphoserine
    242-242 Phosphoserine
    246-246 Phosphoserine
    248-248 Phosphoserine
    263-263 Phosphoserine
    280-280 Phosphoserine
    285-285 Phosphoserine
    305-305 Phosphothreonine
    313-313 Phosphoserine
    367-367 Phosphoserine
    370-370 Phosphothreonine
    401-401 Phosphoserine
    403-403 Phosphoserine
    408-408 Phosphoserine
    568-568 Phosphoserine
 
Prediction
DICHOT
Disorder 1-452,823-837
Known Domain 453-822
SCOPe RPS-Blast
     1aqcA 453-617 3e-53 b.55.1.2 Amyloid beta A4 precursor protein-bindi...
     1x45A1 656-740 3e-31 b.36.1.1 Afadin
     1y7nA1 745-823 2e-29 b.36.1.1 Afadin
SCOP Hmmer
     1aqcA_ 453-617 1.9e-60 b.55.1.2 Amyloid beta A4...
     1wifA_ 631-754 6e-23 PDZ domain-like
     1u3bA2 746-830 1.9e-17 b.36.1.1 Afadin
Pfam RPS-Blast
     PF00640 461-617 1e-06 Phosphotyrosine interaction...
     PF17820 684-741 4e-06 PDZ domain
     PF17820 767-811 5e-05 PDZ domain
Pfam Hmmer
    PF00640 461-618 3e-55 Phosphotyrosine interaction ...
    PF00595 657-739 4.1e-19 PDZ domain
    PF00595 755-819 2.1e-15 PDZ domain