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IID00652  Proto-oncogene vav (Homo sapiens) P15498
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
845
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-584 Monomer :
 Evidence X-RAY 3ky9 A Reference
       Region 3ky9 A 2-129 order
       Region 3ky9 A 130-141 disorder
       Region 3ky9 A 142-150 order
       Region 3ky9 A 151-155 disorder
       Region 3ky9 A 156-180 order
       Region 3ky9 A 181-188 disorder
       Region 3ky9 A 189-457 order
       Region 3ky9 A 458-462 disorder
       Region 3ky9 A 463-478 order
       Region 3ky9 A 479-481 disorder
       Region 3ky9 A 482-564 order
       Region 3ky9 A 565-584 disorder
 Evidence X-RAY 3ky9 B Reference
       Region 3ky9 B 2-129 order
       Region 3ky9 B 130-137 disorder
       Region 3ky9 B 138-150 order
       Region 3ky9 B 151-155 disorder
       Region 3ky9 B 156-180 order
       Region 3ky9 B 181-188 disorder
       Region 3ky9 B 189-416 order
       Region 3ky9 B 417-419 disorder
       Region 3ky9 B 420-565 order
       Region 3ky9 B 566-584 disorder
Seq 189-565 Hetero dimer : IID00312Complex
 Evidence X-RAY 3bji A Reference
       Region 3bji A 189-457 order
       Region 3bji A 458-462 disorder
       Region 3bji A 463-565 order
 Evidence X-RAY 3bji B Reference
       Region 3bji B 189-457 order
       Region 3bji B 458-463 disorder
       Region 3bji B 464-475 order
       Region 3bji B 476-479 disorder
       Region 3bji B 480-565 order
Seq 629-775 Monomer :
 Evidence NMR 2crh A Reference
       Region 2crh A 629-775 order
       Region 2crh A 629-640 high_rmsd
       Region 2crh A 750-753 high_rmsd
Seq 629-775 Hetero dimer : IID00318Complex
 Evidence NMR 2ror A Reference
       Region 2ror A 629-775 order
       Region 2ror A 629-641 high_rmsd
       Region 2ror A 750-753 high_rmsd
Seq 664-767 Hetero dimer : IID50282Complex
 Evidence NMR 2lct A Reference
       Region 2lct A 664-767 order
 Evidence NMR 2mc1 A Reference
       Region 2mc1 A 664-767 order
       Region 2mc1 A 700-701 high_rmsd
Seqphosphorylation
    826-826 Phosphotyrosine
    844-844 Phosphotyrosine
 
Prediction
DICHOT
Disorder 1-1,565-595,781-783,845-845
Known Domain 2-564,596-780,784-844
SCOPe RPS-Blast
     2d86A1 1-130 3e-47 a.40.1.0 automated matches
     1f5xA 169-375 7e-87 a.87.1.1 beta-pix
     2dfkA2 380-509 2e-19 b.55.1.1 3-phosphoinositide dependent protein ...
     2yuuA1 514-562 5e-09 g.49.1.0 automated matches
     1gcqC1 595-659 2e-23 b.34.2.1 53BP2
     2dlzA1 663-765 5e-35 d.93.1.0 automated matches
     2i0nA1 787-838 2e-21 b.34.2.0 automated matches
SCOP Hmmer
     1pxyA_ 2-235 2.3e-48 a.40.1.1 Actin binding dom...
     1f5xA_ 170-375 2e-54 a.87.1.1 beta-pix
     2dfkA2 380-542 1.8e-36 b.55.1.1 3-phosphoinosit...
     1wieA_ 589-676 1e-13 SH3-domain
     1xa6A2 633-753 3.2e-27 d.93.1.1 Abl tyrosine ki...
     1i1jA_ 781-839 4.6e-23 b.34.2.1 53BP2
Pfam RPS-Blast
     PF11971 29-69 6e-07 CAMSAP CH domain
     PF00130 516-567 4e-08 Phorbol esters/diacylglycer...
     PF14604 617-652 1e-04 Variant SH3 domain
     PF14604 789-833 2e-09 Variant SH3 domain
Pfam Hmmer
    PF11971 19-102 2.1e-24 CAMSAP CH domain
    PF00621 198-371 1.1e-44 RhoGEF domain
    PF00169 406-503 4.8e-12 PH domain
    PF00130 516-565 5.8e-14 Phorbol esters/diacylglyce...
    PF00018 617-652 1.1e-10 SH3 domain
    PF00017 671-745 1.4e-20 SH2 domain
    PF00018 788-834 1.7e-19 SH3 domain