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IID00661  5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens) P54646
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
552
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-552 Hetero hexamer : IID00660Complex,IID00686Complex
 Evidence X-RAY 5iso A Reference
       Region 5iso A 1-8 disorder
       Region 5iso A 9-346 order
       Region 5iso A 347-362 disorder
       Region 5iso A 363-377 order
       Region 5iso A 378-396 disorder
       Region 5iso A 397-474 order
       Region 5iso A 475-529 disorder
       Region 5iso A 530-551 order
       Region 5iso A 552-552 disorder
 Evidence X-RAY 5iso C Reference
       Region 5iso C 1-8 disorder
       Region 5iso C 9-297 order
       Region 5iso C 298-299 disorder
       Region 5iso C 300-301 order
       Region 5iso C 302-318 disorder
       Region 5iso C 319-345 order
       Region 5iso C 346-362 disorder
       Region 5iso C 363-374 order
       Region 5iso C 375-395 disorder
       Region 5iso C 396-474 order
       Region 5iso C 475-530 disorder
       Region 5iso C 531-550 order
       Region 5iso C 551-552 disorder
Seq 1-552 Hetero trimer : IID00660Complex,IID00686Complex
 Evidence X-RAY 4cfe C Reference
       Region 4cfe C 1-9 disorder
       Region 4cfe C 10-284 order
       Region 4cfe C 285-326 disorder
       Region 4cfe C 327-346 order
       Region 4cfe C 347-362 disorder
       Region 4cfe C 363-373 order
       Region 4cfe C 374-395 disorder
       Region 4cfe C 396-473 order
       Region 4cfe C 474-531 disorder
       Region 4cfe C 532-551 order
       Region 4cfe C 552-552 disorder
 Evidence X-RAY 4cfe A Reference
       Region 4cfe A 1-7 disorder
       Region 4cfe A 8-295 order
       Region 4cfe A 296-320 disorder
       Region 4cfe A 321-346 order
       Region 4cfe A 347-362 disorder
       Region 4cfe A 363-376 order
       Region 4cfe A 377-395 disorder
       Region 4cfe A 396-473 order
       Region 4cfe A 474-531 disorder
       Region 4cfe A 532-551 order
       Region 4cfe A 552-552 disorder
 Evidence X-RAY 4cff C Reference
       Region 4cff C 1-9 disorder
       Region 4cff C 10-295 order
       Region 4cff C 296-321 disorder
       Region 4cff C 322-346 order
       Region 4cff C 347-362 disorder
       Region 4cff C 363-376 order
       Region 4cff C 377-395 disorder
       Region 4cff C 396-473 order
       Region 4cff C 474-531 disorder
       Region 4cff C 532-551 order
       Region 4cff C 552-552 disorder
 Evidence X-RAY 4cff A Reference
       Region 4cff A 1-7 disorder
       Region 4cff A 8-295 order
       Region 4cff A 296-320 disorder
       Region 4cff A 321-346 order
       Region 4cff A 347-362 disorder
       Region 4cff A 363-375 order
       Region 4cff A 376-395 disorder
       Region 4cff A 396-473 order
       Region 4cff A 474-531 disorder
       Region 4cff A 532-551 order
       Region 4cff A 552-552 disorder
 Evidence X-RAY 4zhx A Reference
       Region 4zhx A 2-8 disorder
       Region 4zhx A 9-298 order
       Region 4zhx A 299-320 disorder
       Region 4zhx A 321-344 order
       Region 4zhx A 345-398 disorder
       Region 4zhx A 399-474 order
       Region 4zhx A 475-531 disorder
       Region 4zhx A 532-550 order
       Region 4zhx A 551-552 disorder
 Evidence X-RAY 4zhx C Reference
       Region 4zhx C 2-8 disorder
       Region 4zhx C 9-298 order
       Region 4zhx C 299-301 disorder
       Region 4zhx C 302-345 order
       Region 4zhx C 346-354 disorder
       Region 4zhx C 355-375 order
       Region 4zhx C 376-395 disorder
       Region 4zhx C 396-473 order
       Region 4zhx C 474-531 disorder
       Region 4zhx C 532-551 order
       Region 4zhx C 552-552 disorder
Seq 2-347,397-552 Hetero pentamer : IID00660Complex,IID00686Complex,Q13131
 Evidence X-RAY 5ezv A Reference
       Region 5ezv A 2-7 disorder
       Region 5ezv A 8-344 order
       Region 5ezv A 345-347 disorder
       Region 5ezv A 397-398 disorder
       Region 5ezv A 399-474 order
       Region 5ezv A 475-531 disorder
       Region 5ezv A 532-551 order
       Region 5ezv A 552-552 disorder
Seq 2-347,397-552 Hetero pentamer : IID00660Complex,IID00686Complex,Q13131
 Evidence X-RAY 5ezv C Reference
       Region 5ezv C 2-8 disorder
       Region 5ezv C 9-316 order
       Region 5ezv C 317-318 disorder
       Region 5ezv C 319-345 order
       Region 5ezv C 346-347 disorder
       Region 5ezv C 397-398 disorder
       Region 5ezv C 399-475 order
       Region 5ezv C 476-529 disorder
       Region 5ezv C 530-551 order
       Region 5ezv C 552-552 disorder
Seq 6-279 Monomer :
 Evidence X-RAY 3aqv A Reference
       Region 3aqv A 6-6 disorder
       Region 3aqv A 7-170 order
       Region 3aqv A 171-176 disorder
       Region 3aqv A 177-279 order
 Evidence X-RAY 2h6d A Reference
       Region 2h6d A 6-9 disorder
       Region 2h6d A 10-166 order
       Region 2h6d A 167-179 disorder
       Region 2h6d A 180-278 order
       Region 2h6d A 279-279 disorder
 Evidence X-RAY 2yza A Reference
       Region 2yza A 6-9 disorder
       Region 2yza A 10-166 order
       Region 2yza A 167-177 disorder
       Region 2yza A 178-278 order
       Region 2yza A 279-279 disorder
Seq 282-339 Monomer :
 Evidence NMR 2ltu A Reference
       Region 2ltu A 282-339 order
       Region 2ltu A 282-286 high_rmsd
       Region 2ltu A 335-339 high_rmsd
SeqProS verified 171-176 Hetero pentamer : IID00660Complex,IID00686Complex,Q13131
       Region 5ezv A 8-344 order
       Region 2h6d A 167-179 disorder
SeqProS verified 171-176 Hetero trimer : IID00660Complex,IID00686Complex
       Region 4cff A 8-295 order
       Region 4cff C 10-295 order
       Region 4cfe A 8-295 order
       Region 4cfe C 10-284 order
       Region 4zhx A 9-298 order
       Region 4zhx C 9-298 order
       Region 2h6d A 167-179 disorder
SeqProS verified 171-176 Hetero pentamer : IID00660Complex,IID00686Complex,Q13131
       Region 5ezv C 9-316 order
       Region 2h6d A 167-179 disorder
Seqphosphorylation
    172-172 Phosphothreonine; by LKB1 and CaMKK2
    258-258 Phosphothreonine
    377-377 Phosphoserine
    491-491 Phosphoserine
 
Prediction
DICHOT
Disorder 1-7,474-552
Known Domain 8-473
SCOPe RPS-Blast
     3fe3A 13-327 e-149 d.144.1.0 automated matches
     2v8qA1 402-552 1e-50 d.129.6.2 5'-AMP-activated protein kinase cata...
SCOP Hmmer
     1omwA3 13-348 1.7e-96 d.144.1.7 3-phosphoinosit...
     2v8qA1 402-552 1.1e-49 d.129.6.2 5'-AMP-activat...
Pfam RPS-Blast
     PF06293 30-171 4e-08 Lipopolysaccharide kinase (K...
     PF16579 401-506 8e-31 Adenylate sensor of SNF1-li...
Pfam Hmmer
    PF00069 17-268 6.1e-76 Protein kinase domain
    PF16579 401-479 2.3e-17 Adenylate sensor of SNF1-l...