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IID50168  Serine/threonine-protein kinase RAD53 (Saccharomyces cerevisiae (strain ATCC 204508 / S288c)) P22216
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
821
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-164 Monomer :
 Evidence NMR 1g3g A Reference
       Region 1g3g A 1-164 order
       Region 1g3g A 1-27 high_rmsd
       Region 1g3g A 58-58 high_rmsd
       Region 1g3g A 159-164 high_rmsd
 Evidence NMR 1j4o A Reference
       Region 1j4o A 14-164 order
 Evidence NMR 1k3j A Reference
       Region 1k3j A 14-164 order
       Region 1k3j A 14-27 high_rmsd
       Region 1k3j A 160-164 high_rmsd
Seq 1-466 Monomer :
 Evidence X-RAY 5xzv A Reference
       Region 5xzv A 1-15 disorder
       Region 5xzv A 16-78 order
       Region 5xzv A 79-84 disorder
       Region 5xzv A 85-134 order
       Region 5xzv A 135-137 disorder
       Region 5xzv A 138-164 order
       Region 5xzv A 165-189 disorder
       Region 5xzv A 190-344 order
       Region 5xzv A 345-358 disorder
       Region 5xzv A 359-367 order
       Region 5xzv A 368-382 disorder
       Region 5xzv A 383-408 order
       Region 5xzv A 409-410 disorder
       Region 5xzv A 411-424 order
       Region 5xzv A 425-429 disorder
       Region 5xzv A 430-446 order
       Region 5xzv A 447-449 disorder
       Region 5xzv A 450-453 order
       Region 5xzv A 454-455 disorder
       Region 5xzv A 456-465 order
       Region 5xzv A 466-466 disorder
 Evidence X-RAY 5xzv B Reference
       Region 5xzv B 1-31 disorder
       Region 5xzv B 32-134 order
       Region 5xzv B 135-139 disorder
       Region 5xzv B 140-157 order
       Region 5xzv B 158-188 disorder
       Region 5xzv B 189-233 order
       Region 5xzv B 234-237 disorder
       Region 5xzv B 238-342 order
       Region 5xzv B 343-353 disorder
       Region 5xzv B 354-368 order
       Region 5xzv B 369-382 disorder
       Region 5xzv B 383-466 order
 Evidence X-RAY 5xzw A Reference
       Region 5xzw A 1-14 disorder
       Region 5xzw A 15-78 order
       Region 5xzw A 79-86 disorder
       Region 5xzw A 87-134 order
       Region 5xzw A 135-137 disorder
       Region 5xzw A 138-164 order
       Region 5xzw A 165-190 disorder
       Region 5xzw A 191-343 order
       Region 5xzw A 344-356 disorder
       Region 5xzw A 357-367 order
       Region 5xzw A 368-382 disorder
       Region 5xzw A 383-408 order
       Region 5xzw A 409-410 disorder
       Region 5xzw A 411-425 order
       Region 5xzw A 426-428 disorder
       Region 5xzw A 429-446 order
       Region 5xzw A 447-449 disorder
       Region 5xzw A 450-465 order
       Region 5xzw A 466-466 disorder
 Evidence X-RAY 5xzw B Reference
       Region 5xzw B 1-31 disorder
       Region 5xzw B 32-157 order
       Region 5xzw B 158-188 disorder
       Region 5xzw B 189-342 order
       Region 5xzw B 343-353 disorder
       Region 5xzw B 354-368 order
       Region 5xzw B 369-383 disorder
       Region 5xzw B 384-466 order
Seq 3-12 Hetero dimer : IID50174Complex
 Evidence NMR 2jql B Reference
       Region 2jql B 3-12 order
Seq 3-12,14-164 Hetero dimer :
 Evidence NMR 2jqi A Reference
       Region 2jqi A 14-164 order
       Region 2jqi A 14-27 high_rmsd
       Region 2jqi A 160-164 high_rmsd
 Evidence NMR 2jqi B Reference
       Region 2jqi B 3-12 order
Seq 14-164 Hetero dimer : IID50198Complex
 Evidence NMR 1j4q A Reference
       Region 1j4q A 14-164 order
 Evidence NMR 1k3q A Reference
       Region 1k3q A 14-164 order
       Region 1k3q A 14-27 high_rmsd
       Region 1k3q A 160-164 high_rmsd
Seq 14-164 Hetero dimer : IID50186Complex
 Evidence NMR 2a0t A Reference
       Region 2a0t A 14-164 order
       Region 2a0t A 14-27 high_rmsd
       Region 2a0t A 159-164 high_rmsd
Seq 14-164 Hetero dimer : IID50198Complex
 Evidence NMR 1j4p A Reference
       Region 1j4p A 14-164 order
 Evidence NMR 1k3n A Reference
       Region 1k3n A 14-164 order
       Region 1k3n A 14-27 high_rmsd
       Region 1k3n A 160-164 high_rmsd
Seq 22-162 Hetero dimer : P32325
 Evidence X-RAY 5t2f B Reference
       Region 5t2f B 22-27 disorder
       Region 5t2f B 28-157 order
       Region 5t2f B 158-162 disorder
Seq 22-162 Hetero dimer : P32325
 Evidence X-RAY 5t2f C Reference
       Region 5t2f C 22-28 disorder
       Region 5t2f C 29-159 order
       Region 5t2f C 160-162 disorder
Seq 22-162 Hetero trimer : P06243,P32325
 Evidence X-RAY 5t2s A Reference
       Region 5t2s A 22-27 disorder
       Region 5t2s A 28-159 order
       Region 5t2s A 160-162 disorder
Seq 22-162 Hetero trimer : P06243,P32325
 Evidence X-RAY 5t2s C Reference
       Region 5t2s C 22-28 disorder
       Region 5t2s C 29-157 order
       Region 5t2s C 158-162 disorder
Seq 22-162 Hetero dimer : P32325
 Evidence X-RAY 5t2f D Reference
       Region 5t2f D 22-28 disorder
       Region 5t2f D 29-159 order
       Region 5t2f D 160-162 disorder
Seq 22-162 Hetero dimer : P32325
 Evidence X-RAY 5t2f A Reference
       Region 5t2f A 22-29 disorder
       Region 5t2f A 30-155 order
       Region 5t2f A 156-162 disorder
Seq 29-155 Hetero tetramer :
 Evidence X-RAY 1g6g A Reference
       Region 1g6g A 29-155 order
 Evidence X-RAY 1g6g B Reference
       Region 1g6g B 29-31 disorder
       Region 1g6g B 32-155 order
Seq 170-512 Homo dimer :
 Evidence X-RAY 4pdp A Reference
       Region 4pdp A 170-190 disorder
       Region 4pdp A 191-200 order
       Region 4pdp A 201-209 disorder
       Region 4pdp A 210-233 order
       Region 4pdp A 234-237 disorder
       Region 4pdp A 238-265 order
       Region 4pdp A 266-267 disorder
       Region 4pdp A 268-346 order
       Region 4pdp A 347-357 disorder
       Region 4pdp A 358-368 order
       Region 4pdp A 369-381 disorder
       Region 4pdp A 382-471 order
       Region 4pdp A 472-475 disorder
       Region 4pdp A 476-494 order
       Region 4pdp A 495-512 disorder
 Evidence X-RAY 4pdp B Reference
       Region 4pdp B 170-190 disorder
       Region 4pdp B 191-206 order
       Region 4pdp B 207-209 disorder
       Region 4pdp B 210-231 order
       Region 4pdp B 232-238 disorder
       Region 4pdp B 239-265 order
       Region 4pdp B 266-267 disorder
       Region 4pdp B 268-346 order
       Region 4pdp B 347-357 disorder
       Region 4pdp B 358-367 order
       Region 4pdp B 368-382 disorder
       Region 4pdp B 383-471 order
       Region 4pdp B 472-474 disorder
       Region 4pdp B 475-496 order
       Region 4pdp B 497-512 disorder
 Evidence X-RAY 4pds A Reference
       Region 4pds A 170-190 disorder
       Region 4pds A 191-203 order
       Region 4pds A 204-210 disorder
       Region 4pds A 211-229 order
       Region 4pds A 230-240 disorder
       Region 4pds A 241-263 order
       Region 4pds A 264-266 disorder
       Region 4pds A 267-345 order
       Region 4pds A 346-359 disorder
       Region 4pds A 360-368 order
       Region 4pds A 369-381 disorder
       Region 4pds A 382-471 order
       Region 4pds A 472-474 disorder
       Region 4pds A 475-490 order
       Region 4pds A 491-512 disorder
 Evidence X-RAY 4pds B Reference
       Region 4pds B 170-190 disorder
       Region 4pds B 191-200 order
       Region 4pds B 201-209 disorder
       Region 4pds B 210-229 order
       Region 4pds B 230-240 disorder
       Region 4pds B 241-263 order
       Region 4pds B 264-268 disorder
       Region 4pds B 269-345 order
       Region 4pds B 346-357 disorder
       Region 4pds B 358-367 order
       Region 4pds B 368-382 disorder
       Region 4pds B 383-471 order
       Region 4pds B 472-475 disorder
       Region 4pds B 476-494 order
       Region 4pds B 495-512 disorder
Seq 549-730 Monomer :
 Evidence NMR 1dmz A Reference
       Region 1dmz A 573-730 order
       Region 1dmz A 573-573 high_rmsd
       Region 1dmz A 634-638 high_rmsd
 Evidence NMR 1fhq A Reference
       Region 1fhq A 573-730 order
       Region 1fhq A 573-573 high_rmsd
       Region 1fhq A 636-638 high_rmsd
       Region 1fhq A 710-712 high_rmsd
 Evidence NMR 1qu5 A Reference
       Region 1qu5 A 549-730 order
       Region 1qu5 A 549-572 high_rmsd
       Region 1qu5 A 634-638 high_rmsd
Seq 573-730 Hetero dimer : IID50198Complex
 Evidence NMR 1j4l A Reference
       Region 1j4l A 573-730 order
 Evidence NMR 1k2n A Reference
       Region 1k2n A 573-730 order
       Region 1k2n A 573-573 high_rmsd
       Region 1k2n A 636-638 high_rmsd
       Region 1k2n A 710-712 high_rmsd
Seq 573-730 Hetero dimer : IID50198Complex
 Evidence NMR 1fhr A Reference
       Region 1fhr A 573-730 order
       Region 1fhr A 573-573 high_rmsd
       Region 1fhr A 711-712 high_rmsd
 Evidence NMR 1j4k A Reference
       Region 1j4k A 573-730 order
 Evidence NMR 1k2m A Reference
       Region 1k2m A 573-730 order
       Region 1k2m A 637-638 high_rmsd
       Region 1k2m A 710-712 high_rmsd
Seq 800-821 Hetero dimer : IID50170Complex
 Evidence X-RAY 2ygv E Reference
       Region 2ygv E 800-802 disorder
       Region 2ygv E 803-821 order
 Evidence X-RAY 2ygv F Reference
       Region 2ygv F 800-802 disorder
       Region 2ygv F 803-812 order
       Region 2ygv F 813-818 disorder
       Region 2ygv F 819-821 order
 Evidence X-RAY 2ygv G Reference
       Region 2ygv G 800-801 disorder
       Region 2ygv G 802-809 order
       Region 2ygv G 810-815 disorder
       Region 2ygv G 816-821 order
 Evidence X-RAY 2ygv H Reference
       Region 2ygv H 800-802 disorder
       Region 2ygv H 803-809 order
       Region 2ygv H 810-818 disorder
       Region 2ygv H 819-821 order
Seqphosphorylation
    24-24 Phosphoserine
    175-175 Phosphoserine
    547-547 Phosphoserine
    560-560 Phosphoserine
    774-774 Phosphoserine
    793-793 Phosphoserine
 
Prediction
DICHOT
Disorder 1-28,156-190,480-572,731-821
Known Domain 29-155,191-479,573-730
SCOPe RPS-Blast
     1g6gA 29-155 4e-46 b.26.1.2 Afadin
     2ycfA 194-490 3e-97 d.144.1.0 automated matches
     1dmzA 573-730 1e-50 b.26.1.2 Afadin
SCOP Hmmer
     1g3gA_ 1-161 2.2e-37 b.26.1.2 Afadin
     1kobA_ 190-475 3.6e-87 d.144.1.7 3-phosphoinosi...
     1qu5A_ 551-729 3.8e-48 b.26.1.2 Afadin
Pfam RPS-Blast
     PF16697 63-133 7e-09 Inner membrane component of ...
     PF06293 243-344 1e-06 Lipopolysaccharide kinase (...
     PF00498 603-680 8e-05 FHA domain
Pfam Hmmer
    PF00498 66-133 1.8e-18 FHA domain
    PF00069 201-466 9.9e-83 Protein kinase domain
    PF00498 603-680 2.8e-13 FHA domain