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IID50193  Suppressor of cytokine signaling 3 (Mus musculus) O35718
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
225
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 15-185 Hetero dimer : IID50222Complex
 Evidence X-RAY 2hmh A Reference
       Region 2hmh A 15-28 disorder
       Region 2hmh A 29-154 order
       Region 2hmh A 155-163 disorder
       Region 2hmh A 164-168 order
       Region 2hmh A 169-172 disorder
       Region 2hmh A 173-185 order
 Evidence NMR 2bbu A Reference
       Region 2bbu A 22-29 disorder
       Region 2bbu A 30-185 order
       Region 2bbu A 75-77 high_rmsd
       Region 2bbu A 106-118 high_rmsd
       Region 2bbu A 131-162 high_rmsd
       Region 2bbu A 185-185 high_rmsd
Seqdisorder 22-29
 Evidence X-RAY Reference
       Region 22-29 disorder
Seq 22-128,163-185 Hetero tetramer : IID50091Complex,IID50222Complex
 Evidence X-RAY 4gl9 H Reference
       Region 4gl9 H 22-128 order
       Region 4gl9 H 163-163 disorder
       Region 4gl9 H 164-168 order
       Region 4gl9 H 169-171 disorder
       Region 4gl9 H 172-184 order
       Region 4gl9 H 185-185 disorder
Seq 22-128,163-185 Hetero tetramer : IID50091Complex,IID50222Complex
 Evidence X-RAY 4gl9 F Reference
       Region 4gl9 F 22-128 order
       Region 4gl9 F 163-163 disorder
       Region 4gl9 F 164-168 order
       Region 4gl9 F 169-171 disorder
       Region 4gl9 F 172-184 order
       Region 4gl9 F 185-185 disorder
Seq 22-128,163-185 Hetero tetramer : IID50091Complex,IID50222Complex
 Evidence X-RAY 4gl9 G Reference
       Region 4gl9 G 22-128 order
       Region 4gl9 G 163-163 disorder
       Region 4gl9 G 164-168 order
       Region 4gl9 G 169-171 disorder
       Region 4gl9 G 172-184 order
       Region 4gl9 G 185-185 disorder
Seq 22-128,163-185 Hetero tetramer : IID50091Complex,IID50222Complex
 Evidence X-RAY 4gl9 E Reference
       Region 4gl9 E 22-128 order
       Region 4gl9 E 163-163 disorder
       Region 4gl9 E 164-168 order
       Region 4gl9 E 169-171 disorder
       Region 4gl9 E 172-184 order
       Region 4gl9 E 185-185 disorder
Seqdisorder 22-225
 Evidence NMR Reference
       Region 22-225 disorder
Seq 186-225 Hetero trimer : IID50219Complex
 Evidence NMR 2jz3 A Reference
       Region 2jz3 A 186-200 order
       Region 2jz3 A 201-225 disorder
SeqProS verified 22-29 Hetero tetramer : IID50091Complex,IID50222Complex
       Region 4gl9 F 22-128 order
       Region 22-29 disorder
SeqProS verified 22-29 Hetero dimer : IID50222Complex
       Region 2hmh A 173-185 order
       Region 22-29 disorder
SeqProS verified 22-29 Hetero tetramer : IID50091Complex,IID50222Complex
       Region 4gl9 H 22-128 order
       Region 22-29 disorder
SeqProS verified 22-29 Hetero tetramer : IID50091Complex,IID50222Complex
       Region 4gl9 G 22-128 order
       Region 22-29 disorder
SeqProS verified 186-200 Hetero trimer : IID50219Complex
       Region 2jz3 A 186-200 order
       Region 22-225 disorder
 
Prediction
DICHOT
Disorder 1-29
Known Domain 30-225
SCOPe RPS-Blast
     2c9wA2 30-128 1e-29 d.93.1.1 Abl tyrosine kinase
     2c9wA1 176-221 1e-07 a.271.1.1 Suppressor of cytokine signaling 2, ...
SCOP Hmmer
     2c9wA2 32-129 6.3e-25 d.93.1.1 Abl tyrosine kin...
     2c9wA1 176-223 1e-11 a.271.1.1 Suppressor of cy...
Pfam Hmmer
    PF00017 46-127 2.7e-14 SH2 domain
    PF07525 186-219 8.6e-09 SOCS box