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IID50213  Talin-1 (Gallus gallus) P54939
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
2541
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 189-309 Monomer :
 Evidence NMR 2hrj A Reference
       Region 2hrj A 189-309 order
       Region 2hrj A 189-202 high_rmsd
       Region 2hrj A 309-309 high_rmsd
Seq 196-400 Monomer :
 Evidence X-RAY 1mix A Reference
       Region 1mix A 196-400 order
Seq 200-400 Hetero dimer : P05106
 Evidence X-RAY 1miz B Reference
       Region 1miz B 200-400 order
 Evidence X-RAY 1mk7 D Reference
       Region 1mk7 D 209-318 order
       Region 1mk7 D 319-323 disorder
       Region 1mk7 D 324-400 order
 Evidence X-RAY 1mk7 B Reference
       Region 1mk7 B 209-400 order
 Evidence X-RAY 1mk9 D Reference
       Region 1mk9 D 209-400 order
 Evidence X-RAY 1mk9 B Reference
       Region 1mk9 B 209-321 order
       Region 1mk9 B 322-324 disorder
       Region 1mk9 B 325-398 order
       Region 1mk9 B 399-400 disorder
 Evidence X-RAY 1mk9 H Reference
       Region 1mk9 H 209-318 order
       Region 1mk9 H 319-322 disorder
       Region 1mk9 H 323-400 order
 Evidence X-RAY 1mk9 F Reference
       Region 1mk9 F 209-398 order
       Region 1mk9 F 399-400 disorder
Seq 309-400 Hetero dimer : IID50232Complex
 Evidence NMR 2k00 A Reference
       Region 2k00 A 309-400 order
Seq 309-405 Hetero dimer : IID50194Complex
 Evidence NMR 2h7d A Reference
       Region 2h7d A 309-405 order
 Evidence NMR 2h7e A Reference
       Region 2h7e A 309-405 order
Seq 820-844 Hetero dimer : P12003
 Evidence X-RAY 1zvz B Reference
       Region 1zvz B 820-820 disorder
       Region 1zvz B 821-842 order
       Region 1zvz B 843-844 disorder
Seq 849-879 Hetero dimer : P12003
 Evidence X-RAY 1u6h B Reference
       Region 1u6h B 849-852 disorder
       Region 1u6h B 853-876 order
       Region 1u6h B 877-879 disorder
Seq 1944-1969 Hetero dimer : P12003
 Evidence X-RAY 1xwj B Reference
       Region 1xwj B 1944-1945 disorder
       Region 1xwj B 1946-1969 order
Seq 1944-1969 Hetero dimer : P18206
 Evidence X-RAY 1rkc B Reference
       Region 1rkc B 1944-1969 order
Seq 2344-2368 Hetero dimer : P12003
 Evidence X-RAY 1zw2 B Reference
       Region 1zw2 B 2344-2364 order
       Region 1zw2 B 2365-2368 disorder
SeqProS possible 316-326,400-405 Same region of mouse homolog (P26039, 89%identity) is disordered in the free state. Hetero dimer : IID50194Complex
       Region 2h7e A 309-405 order
       Region 2h7d A 309-405 order
 
Prediction
DICHOT
Disorder 1-1,399-485,783-787,912-950,1026-1044,1816-1836,1973-1973,2289-2294,2482-2541
Known Domain 2-398,486-782,788-911,951-1025,1045-1815,1837-1972,1974-2288,2295-2481
SCOPe RPS-Blast
     1mixA1 196-308 3e-49 a.11.2.1 Erythroid membrane protein 4.1R
     1mixA2 309-400 4e-36 b.55.1.5 Erythroid membrane protein 4.1R
     1sj7A1 488-654 8e-44 a.215.1.1 A middle domain of Talin 1
     1sj8A2 658-782 3e-30 a.216.1.1 Huntingtin interacting protein 12
     1u89A1 755-889 6e-34 a.216.1.1 Huntingtin interacting protein 12
     1sj8A2 941-1040 1e-07 a.216.1.1 Huntingtin interacting protein 12
     1u89A1 1109-1183 2e-07 a.216.1.1 Huntingtin interacting protein 12
     2b0hA1 1230-1349 2e-08 a.24.9.2 Talin 1
     2b0hA1 1842-1972 1e-37 a.24.9.2 Talin 1
     2b0hA1 2006-2133 1e-08 a.24.9.2 Talin 1
     1r0dA 2295-2486 3e-42 a.216.1.1 Huntingtin interacting protein 12
SCOP Hmmer
     1wgrA_ 79-136 4.4e-09 Ubiquitin-like
     1mixA1 195-308 9.7e-37 a.11.2.1 Erythroid membr...
     1mixA2 309-399 2e-28 b.55.1.5 Erythroid membran...
     1sj7A1 488-653 2.8e-73 a.215.1.1 A middle domai...
     1sj8A2 658-782 1.9e-53 a.216.1.1 Huntingtin int...
     1u89A1 752-888 2.4e-56 a.216.1.1 Huntingtin int...
     1u89A1 920-982 3.3e-06 a.216.1.1 Huntingtin int...
     2b0hA1 1074-1206 2.4e-25 a.24.9.2 Talin 1
     2b0hA1 1223-1360 1.3e-41 a.24.9.2 Talin 1
     1r0dA_ 1420-1554 9.1e-14 a.216.1.1 Huntingtin i...
     2b0hA1 1592-1658 1.5e-07 a.24.9.2 Talin 1
     2b0hA1 1693-1807 5.3e-10 a.24.9.2 Talin 1
     2b0hA1 1840-1972 7.3e-48 a.24.9.2 Talin 1
     2b0hA1 2006-2131 4e-09 a.24.9.2 Talin 1
     1r0dA_ 2294-2480 6.5e-53 a.216.1.1 Huntingtin i...
Pfam RPS-Blast
     PF16511 12-82 1e-19 N-terminal or F0 domain of Ta...
     PF09379 90-163 9e-09 FERM N-terminal domain
     PF00373 207-313 5e-14 FERM central domain
     PF02174 313-397 4e-09 PTB domain (IRS-1 type)
     PF09141 491-652 3e-37 Talin, middle domain
     PF01608 661-761 3e-10 I/LWEQ domain
     PF08913 1101-1196 4e-04 Vinculin Binding Site
     PF08913 1233-1352 1e-17 Vinculin Binding Site
     PF08913 1699-1817 3e-05 Vinculin Binding Site
     PF08913 1848-1972 2e-34 Vinculin Binding Site
     PF08913 2010-2133 2e-05 Vinculin Binding Site
     PF01608 2384-2478 2e-12 I/LWEQ domain
Pfam Hmmer
    PF16511 4-83 5.7e-37 N-terminal or F0 domain of Ta...
    PF09379 90-185 5.8e-30 FERM N-terminal domain
    PF00373 206-313 6.9e-31 FERM central domain
    PF09141 491-652 2.2e-58 Talin, middle domain
    PF08913 1233-1349 3.7e-09 Vinculin Binding Site
    PF08913 1848-1972 1.3e-62 Vinculin Binding Site
    PF01608 2385-2529 1.7e-52 I/LWEQ domain