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IID50269  Tyrosine-protein kinase ABL1 (Mus musculus) P00520
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
1123
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 27-515 Monomer :
 Evidence X-RAY 1opk A Reference
       Region 1opk A 27-63 disorder
       Region 1opk A 64-512 order
       Region 1opk A 513-515 disorder
Seq 61-121 Hetero dimer : IID50285Complex
 Evidence X-RAY 1abo A Reference
       Region 1abo A 61-63 disorder
       Region 1abo A 64-121 order
 Evidence X-RAY 1abo B Reference
       Region 1abo B 61-63 disorder
       Region 1abo B 64-121 order
Seq 61-121 Homo dimer :
 Evidence X-RAY 1abq A Reference
       Region 1abq A 61-64 disorder
       Region 1abq A 65-120 order
       Region 1abq A 121-121 disorder
Seq 229-515 Monomer :
 Evidence X-RAY 3dk3 A Reference
       Region 3dk3 A 233-274 order
       Region 3dk3 A 275-278 disorder
       Region 3dk3 A 279-502 order
       Region 3dk3 A 503-514 disorder
 Evidence X-RAY 3dk3 B Reference
       Region 3dk3 B 233-273 order
       Region 3dk3 B 274-277 disorder
       Region 3dk3 B 278-505 order
       Region 3dk3 B 506-514 disorder
 Evidence X-RAY 3dk6 A Reference
       Region 3dk6 A 233-248 order
       Region 3dk6 A 249-250 disorder
       Region 3dk6 A 251-273 order
       Region 3dk6 A 274-278 disorder
       Region 3dk6 A 279-502 order
       Region 3dk6 A 503-514 disorder
 Evidence X-RAY 3dk6 B Reference
       Region 3dk6 B 233-233 disorder
       Region 3dk6 B 234-247 order
       Region 3dk6 B 248-254 disorder
       Region 3dk6 B 255-273 order
       Region 3dk6 B 274-278 disorder
       Region 3dk6 B 279-505 order
       Region 3dk6 B 506-514 disorder
 Evidence X-RAY 3dk7 A Reference
       Region 3dk7 A 233-274 order
       Region 3dk7 A 275-278 disorder
       Region 3dk7 A 279-502 order
       Region 3dk7 A 503-505 disorder
 Evidence X-RAY 3dk7 B Reference
       Region 3dk7 B 233-273 order
       Region 3dk7 B 274-277 disorder
       Region 3dk7 B 278-505 order
 Evidence X-RAY 1fpu A Reference
       Region 1fpu A 229-499 order
       Region 1fpu A 500-515 disorder
 Evidence X-RAY 1fpu B Reference
       Region 1fpu B 229-386 order
       Region 1fpu B 387-391 disorder
       Region 1fpu B 392-499 order
       Region 1fpu B 500-515 disorder
 Evidence X-RAY 2hzn A Reference
       Region 2hzn A 229-250 order
       Region 2hzn A 251-253 disorder
       Region 2hzn A 254-273 order
       Region 2hzn A 274-275 disorder
       Region 2hzn A 276-501 order
       Region 2hzn A 502-515 disorder
 Evidence X-RAY 1iep A Reference
       Region 1iep A 229-498 order
       Region 1iep A 499-515 disorder
 Evidence X-RAY 1iep B Reference
       Region 1iep B 229-498 order
       Region 1iep B 499-515 disorder
 Evidence X-RAY 3ik3 A Reference
       Region 3ik3 A 229-385 order
       Region 3ik3 A 386-391 disorder
       Region 3ik3 A 392-513 order
 Evidence X-RAY 3ik3 B Reference
       Region 3ik3 B 229-513 order
 Evidence X-RAY 3k5v A Reference
       Region 3k5v A 229-276 order
       Region 3k5v A 277-277 disorder
       Region 3k5v A 278-510 order
       Region 3k5v A 511-515 disorder
 Evidence X-RAY 3k5v B Reference
       Region 3k5v B 229-274 order
       Region 3k5v B 275-277 disorder
       Region 3k5v B 278-510 order
       Region 3k5v B 511-515 disorder
 Evidence X-RAY 3kf4 A Reference
       Region 3kf4 A 229-274 order
       Region 3kf4 A 275-279 disorder
       Region 3kf4 A 280-514 order
       Region 3kf4 A 515-515 disorder
 Evidence X-RAY 3kf4 B Reference
       Region 3kf4 B 229-273 order
       Region 3kf4 B 274-276 disorder
       Region 3kf4 B 277-501 order
       Region 3kf4 B 502-515 disorder
 Evidence X-RAY 3kfa A Reference
       Region 3kfa A 229-511 order
       Region 3kfa A 512-515 disorder
 Evidence X-RAY 3kfa B Reference
       Region 3kfa B 229-511 order
       Region 3kfa B 512-515 disorder
 Evidence X-RAY 1m52 A Reference
       Region 1m52 A 229-231 disorder
       Region 1m52 A 232-502 order
       Region 1m52 A 503-515 disorder
 Evidence X-RAY 1m52 B Reference
       Region 1m52 B 229-231 disorder
       Region 1m52 B 232-503 order
       Region 1m52 B 504-515 disorder
 Evidence X-RAY 3ms9 A Reference
       Region 3ms9 A 229-229 disorder
       Region 3ms9 A 230-273 order
       Region 3ms9 A 274-279 disorder
       Region 3ms9 A 280-387 order
       Region 3ms9 A 388-389 disorder
       Region 3ms9 A 390-498 order
       Region 3ms9 A 499-515 disorder
 Evidence X-RAY 3ms9 B Reference
       Region 3ms9 B 229-273 order
       Region 3ms9 B 274-276 disorder
       Region 3ms9 B 277-498 order
       Region 3ms9 B 499-515 disorder
 Evidence X-RAY 3mss A Reference
       Region 3mss A 229-231 disorder
       Region 3mss A 232-273 order
       Region 3mss A 274-279 disorder
       Region 3mss A 280-388 order
       Region 3mss A 389-389 disorder
       Region 3mss A 390-498 order
       Region 3mss A 499-515 disorder
 Evidence X-RAY 3mss B Reference
       Region 3mss B 229-231 disorder
       Region 3mss B 232-273 order
       Region 3mss B 274-279 disorder
       Region 3mss B 280-388 order
       Region 3mss B 389-389 disorder
       Region 3mss B 390-498 order
       Region 3mss B 499-515 disorder
 Evidence X-RAY 3mss C Reference
       Region 3mss C 229-231 disorder
       Region 3mss C 232-273 order
       Region 3mss C 274-279 disorder
       Region 3mss C 280-388 order
       Region 3mss C 389-389 disorder
       Region 3mss C 390-498 order
       Region 3mss C 499-515 disorder
 Evidence X-RAY 3mss D Reference
       Region 3mss D 229-231 disorder
       Region 3mss D 232-273 order
       Region 3mss D 274-279 disorder
       Region 3mss D 280-388 order
       Region 3mss D 389-389 disorder
       Region 3mss D 390-498 order
       Region 3mss D 499-515 disorder
 Evidence X-RAY 1opj A Reference
       Region 1opj A 229-510 order
       Region 1opj A 511-515 disorder
 Evidence X-RAY 1opj B Reference
       Region 1opj B 229-512 order
       Region 1opj B 513-515 disorder
 Evidence X-RAY 3oxz A Reference
       Region 3oxz A 229-273 order
       Region 3oxz A 274-279 disorder
       Region 3oxz A 280-385 order
       Region 3oxz A 386-392 disorder
       Region 3oxz A 393-394 order
       Region 3oxz A 395-397 disorder
       Region 3oxz A 398-511 order
 Evidence X-RAY 3oy3 A Reference
       Region 3oy3 A 229-511 order
 Evidence X-RAY 3oy3 B Reference
       Region 3oy3 B 229-511 order
 Evidence X-RAY 2qoh A Reference
       Region 2qoh A 229-275 order
       Region 2qoh A 276-278 disorder
       Region 2qoh A 279-501 order
       Region 2qoh A 502-515 disorder
 Evidence X-RAY 2qoh B Reference
       Region 2qoh B 229-274 order
       Region 2qoh B 275-277 disorder
       Region 2qoh B 278-511 order
       Region 2qoh B 512-515 disorder
 Evidence X-RAY 2z60 A Reference
       Region 2z60 A 229-275 order
       Region 2z60 A 276-278 disorder
       Region 2z60 A 279-511 order
       Region 2z60 A 512-515 disorder
Seq 757-765 Hetero dimer : Q64010
 Evidence X-RAY 5ih2 M Reference
       Region 5ih2 M 757-765 order
 Evidence X-RAY 5ih2 N Reference
       Region 5ih2 N 757-765 order
SeqProS predicted 757-765 The unbound state of this region is predicted to be disordered by DICHOT and MobiDB. Hetero dimer : Q64010
       Region 5ih2 M 757-765 order
       Region 5ih2 N 757-765 order
Seqphosphorylation
    50-50 Phosphoserine
    70-70 Phosphotyrosine; by autocatalysis
    115-115 Phosphotyrosine
    128-128 Phosphotyrosine
    139-139 Phosphotyrosine
    172-172 Phosphotyrosine
    185-185 Phosphotyrosine
    215-215 Phosphotyrosine
    226-226 Phosphotyrosine; by autocatalysis
    229-229 Phosphoserine
    253-253 Phosphotyrosine
    257-257 Phosphotyrosine
    393-393 Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases
    413-413 Phosphotyrosine
    446-446 Phosphoserine
    547-547 Phosphothreonine
    559-559 Phosphoserine
    569-569 Phosphoserine
    618-618 Phosphoserine; by PAK2
    619-619 Phosphoserine; by PAK2
    620-620 Phosphoserine
    658-658 Phosphoserine
    682-682 Phosphoserine
    717-717 Phosphoserine
    734-734 Phosphothreonine
    750-750 Phosphothreonine
    812-812 Phosphothreonine
    821-821 Phosphothreonine
    844-844 Phosphothreonine
    909-909 Phosphoserine
    970-970 Phosphoserine
Seqacetylation
    710-710 N6-acetyllysine; by EP300
 
Prediction
DICHOT
Disorder 1-63,513-1016
Known Domain 64-512,1017-1123
SCOPe RPS-Blast
     4j9fA 60-120 3e-22 b.34.2.1 53BP2
     4eihA 121-221 5e-46 d.93.1.1 Abl tyrosine kinase
     4rfzA 236-499 e-137 d.144.1.7 3-phosphoinositide dependent protein ...
SCOP Hmmer
     1uffA_ 62-147 4.4e-21 SH3-domain
     1a81A1 122-262 1.6e-38 d.93.1.1 Abl tyrosine ki...
     1m14A_ 231-498 1.6e-85 d.144.1.7 3-phosphoinosi...
Pfam RPS-Blast
     PF14604 68-112 8e-06 Variant SH3 domain
     PF00017 127-202 4e-07 SH2 domain
     PF07714 243-491 1e-09 Protein tyrosine kinase
     PF03154 728-984 5e-04 Atrophin-1 family
     PF08919 1019-1123 2e-20 F-actin binding
Pfam Hmmer
    PF00018 67-113 1.1e-15 SH3 domain
    PF00017 127-202 1e-26 SH2 domain
    PF07714 242-492 2.7e-102 Protein tyrosine kinase
    PF08919 1019-1123 1.2e-32 F-actin binding