20210801 20180803 20180425 20210801 IID00469 C-terminal-binding protein 1 Homo sapiens 440 Q13363 Q4W5N3 Q7Z2Q5 Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Nucleus. SL-0191 unkown Cytoplasm. SL-0086 unkown 0 0 Phosphoserine 300 300 Phosphoserine; by HIPK2 422 422 MGSSHLLNKGLPLGVRPPIMNGPLHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAATHWASMDPAVVHPELNGAAYRYPPGVVGVAPTGIPAAVEGIVPSAMSLSHGLPPVAHPPHAPSPGQTVKPEADRDHASDQL 1 1mx3A 28 352 order 1 2 1mx3A 353 353 disorder 1 3 4lceA 28 353 order 2 4 4u6qA 28 353 order 4 5 4u6sA 28 353 order 3 1 1mx3 X-RAY 7 12419229 V.KUMAR,J.E.CARLSON,K.E.OHGI,T.E.EDWARDS,D.W.ROSE,C.R.ESCALANTE,A.K.AGGARWAL TRANSCRIPTION COREPRESSOR CTBP IS AN NAD+-REGULATED DEHYDROGENASE 2002 MOL.CELL 10 857 x-ray 1mx3 A 28 353 100 1 353 353 1 1mx3_1 2714 Monomer monomer 1mx3A Q13363 IID00469 2 4lce X-RAY 298K 7.5 24657618 B.J.HILBERT,S.R.GROSSMANN,C.A.SCHIFFER,W.E.ROYER CRYSTAL STRUCTURES OF HUMAN CTBP IN COMPLEX WITH SUBSTRATE MTOB REVEAL ACTIVE SITE FEATURES USEFUL FOR INHIBITOR DESIGN. 2014 FEBS LETT. 588 1743 x-ray 4lce A 28 353 100 0 1 4lce_1 782 Homo dimer 4lceA Q13363 IID00469 4lceA-4lceA 3 4u6s X-RAY 277K 7.5 25636004 B.J.HILBERT,B.L.MORRIS,K.C.ELLIS,J.L.PAULSEN,C.A.SCHIFFER,S.R.GROSSMAN,W.E.ROYER STRUCTURE-GUIDED DESIGN OF A HIGH AFFINITY INHIBITOR TO HUMAN CTBP. 2015 ACS CHEM.BIOL. 10 1118 x-ray 4u6s A 28 353 100 0 1 4u6s_1 782 Homo dimer 4u6sA Q13363 IID00469 4u6sA-4u6sA 2 4u6s_2 3120 Homo tetramer 4u6sA Q13363 IID00469 4 4u6q X-RAY 277K 7.5 25636004 B.J.HILBERT,B.L.MORRIS,K.C.ELLIS,J.L.PAULSEN,C.A.SCHIFFER,S.R.GROSSMAN,W.E.ROYER STRUCTURE-GUIDED DESIGN OF A HIGH AFFINITY INHIBITOR TO HUMAN CTBP. 2015 ACS CHEM.BIOL. 10 1118 x-ray 4u6q A 28 353 100 0 1 4u6q_1 782 Homo dimer 4u6qA Q13363 IID00469 4u6qA-4u6qA 28-352 1-27,353-440 1384 PF02826 134->317 6.6e-60 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain hmm pfm 4030 1mx3A2 27->144 3.4e-65 hmm scp 4031 1mx3A2 296->352 2.3e-17 hmm scp 4032 1mx3A1 128->318 8.8e-59 hmm scp 6505 PF00389 29->344 1e-27 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain rps pfm 8923 1mx3A2 28->155 4e-47 rps scp 8924 1mx3A1 126->318 2e-86 rps scp