20210801 20180803 20180425 20210801 IID00473 Four and a half LIM domains protein 2 LIM domain protein DRAL Skeletal muscle LIM-protein 3 Homo sapiens 279 Q14192 Q13229 Q13644 Q2I5I4 Q5TM15 Q9P294 May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Cytoplasm. SL-0086 unkown Nucleus. SL-0191 unkown 0 0 Phosphoserine 238 238 MTERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI 2 1x4lA 221 279 order 1 3 2d8zA 162 218 order 2 4 2miuA 1 98 order 4 5 1x4kA 101 159 order 3 6 1x4lA 231 231 high_rmsd 1 1 1x4l NMR F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,S.YOKOYAMA SOLUTION STRUCTURE OF LIM DOMAIN IN FOUR AND A HALF LIM DOMAINS PROTEIN 2 TO BE PUBLISHED nmr 1x4l A 221 279 100 0 1 1x4l 3965 Monomer monomer 1x4lA Q14192 IID00473 2 2d8z NMR X.R.QIN,F.HAYASHI,S.YOKOYAMA SOLUTION STRUCTURE OF THE THIRD LIM DOMAIN OF FOUR AND A HALF LIM DOMAINS PROTEIN 2 (FHL-2) TO BE PUBLISHED nmr 2d8z A 162 218 100 0 1 2d8z 3524 Monomer monomer 2d8zA Q14192 IID00473 3 1x4k NMR F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,S.YOKOYAMA SOLUTION STRUCTURE OF LIM DOMAIN IN LIM-PROTEIN 3 TO BE PUBLISHED nmr 1x4k A 101 159 100 0 1 1x4k 3964 Monomer monomer 1x4kA Q14192 IID00473 4 2miu NMR Y.YANG,Y.SUN,E.E.MEDRANO,X.TIAN,M.A.WEISS STRUCTURE OF FHL2 LIM ADAPTOR AND ITS INTERACTION WITH SKI TO BE PUBLISHED nmr 2miu A 1 98 100 0 1 2miu_1 2670 Monomer monomer 2miuA Q14192 IID00473 1-159,162-218,221-279 160-161,219-220 1390 PF00412 40->96 2.7e-14 LIM domain hmm pfm 1391 PF00412 101->157 9.7e-17 LIM domain hmm pfm 1392 PF00412 162->216 6e-16 LIM domain hmm pfm 1393 PF00412 221->275 7.4e-14 LIM domain hmm pfm 4037 1b8tA2 7->71 2e-17 hmm scp 4038 1b8tA2 68->132 7.9e-18 hmm scp 4039 1b8tA2 129->191 2.7e-20 hmm scp 4040 1b8tA2 188->254 9.5e-20 hmm scp 4041 1x4lA2 250->278 3.7e-13 hmm scp 8929 2cuqA1 7->37 1e-04 rps scp 8930 1x4kA2 101->127 5e-06 rps scp 8931 1x4kA1 128->159 5e-07 rps scp 8932 2curA2 162->186 3e-06 rps scp 8933 2cuqA1 187->218 4e-06 rps scp 8934 1x68A1 221->249 7e-07 rps scp 8935 1x68A2 250->279 5e-07 rps scp