20210801 20180803 20180328 20210801 IID00517 Nanos homolog 1 EC_Rep1a Homo sapiens 292 Q8WY41 May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. Cytoplasm. SL-0086 unkown Cytoplasm, Perinuclear region. SL-0198 unkown C2HC 1 214 241 C2HC 2 249 265 0 0 MEAFPWAPRSPRRGRAPPPMALVPSARYVSAPGPAHPQPFSSWNDYLGLATLITKAVDGEPRFGCARGGNGGGGSPPSSSSSSCCSPHTGAGPGALGPALGPPDYDEDDDDDSDEPGSRGRYLGSALELRALELCAGPAEAGLLEERFAELSPFAGRAAAVLLGCAPAAAAAATTTSEATPREERAPAWAAEPRLHAASGAAAARLLKPELQVCVFCRNNKEAMALYTTHILKGPDGRVLCPVLRRYTCPLCGASGDNAHTIKYCPLSKVPPPPARPPPRSARDGPPGKKLR 1 4cqoB 40 54 order 1 2 4cqoB 55 56 disorder 1 3 4cqoD 40 53 order 1 4 4cqoD 54 56 disorder 1 1 4cqo X-RAY 7 24736845 D.BHANDARI,T.RAISCH,O.WEICHENRIEDER,S.JONAS,E.IZAURRALDE 2014 GENES DEV. 28 888 x-ray 4cqo B 40 56 100 1 55 56 x-ray 4cqo D 40 56 100 1 54 56 1 4cqo_1 1001 Hetero dimer 4cqoD Q8WY41 IID00517 4cqoC A5YKK6 IID00423 4cqoD-4cqoC 2 4cqo_2 1001 Hetero dimer 4cqoB Q8WY41 IID00517 4cqoA A5YKK6 IID00423 4cqoB-4cqoA 214-269 1-213,270-292 1513 PF05741 214->266 1.7e-29 Nanos RNA binding domain hmm pfm 6625 PF05741 214->266 2e-21 Nanos RNA binding domain rps pfm