20210801 20180803 20180425 20210801 IID00624 Twist-related protein 1 Class A basic helix-loop-helix protein 38 H-twist Homo sapiens 202 Q15672 A4D128 Q92487 Q99804 Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer. Nucleus. SL-0191 unkown 0 0 0 0 MMQDVSSSPVSPADDSLSNSEEEPDRQQPPSGKRGGRKRRSSRRSAGGGAGPGGAAGGGVGGGDEPGSPAQGKRGKKSAGCGGGGGAGGGGGSSSGGGSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH 1 2mjvA 68 79 order 1 1 2mjv NMR 24525235 J.SHI,Y.WANG,L.ZENG,Y.WU,J.DENG,Q.ZHANG,Y.LIN,J.LI,T.KANG,M.TAO,E.RUSINOVA,G.ZHANG,C.WANG,H.ZHU,J.YAO,Y.X.ZENG,B.M.EVERS,M.M.ZHOU,B.P.ZHOU 2014 CANCER CELL 25 210 nmr 2mjv A 68 79 83 0 1 2mjv_1 2673 Hetero dimer 2mjvB O60885 IID00111 2mjvA Q15672 IID00624 2mjvB-2mjvA 109-167 1-108,168-202 1772 PF00010 109->159 5.6e-20 Helix-loop-helix DNA-binding domain hmm pfm 4333 1r05A_ 108->182 1.6e-21 HLH, helix-loop-helix DNA-binding domain hmm scp 9217 1mdyA 109->164 2e-23 rps scp