20210801 20180803 20180328 20210801 IID50180 BAG family molecular chaperone regulator 1 Bcl-2-associated athanogene 1 Mus musculus 355 Q60739 Q561N1 Q6IS45 Q9D7K6 Co-chaperone for HSP70 and HSC70 chaperone proteins (PubMed:9873016). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. Secreted. SL-0243 unkown 0 0 0 0 MAGRSAARRPRGDREPLGPRLRAPRPAREPRQSESRAERGLPPSQRSSVRSAASGHDRSTRGAPAGACKPRVKKKVRPRSSQSEKVGSSSRELTRSKKVTRSKNVTGTQVEEVTKIEEATQTEEVTVAEEVTQTDNMAKTEEMVQTEEMETPRLSVIVTHSNERYDLLVTPQQGNSEPVVQDLAQLVEEATGVPLPFQKLIFKGKSLKEMETPLSALGMQNGCRVMLIGEKSNPEEEVELKKLKDLEVSAEKIANHLQELNKELSGIQQGFLAKELQAEALCKLDRKVKATIEQFMKILEEIDTMVLPEQFKDSRLKRKNLVKKVQVFLAECDTVEQYICQETERLQSTNLALAE 1 1i6zA 226 355 order 1 2 2lwpA 137 233 order 2 3 2m8sA 137 233 order 3 4 2lwpA 137 137 high_rmsd 2 5 1i6zA 226 232 high_rmsd 1 6 1i6zA 348 355 high_rmsd 1 1 1i6z NMR 11276257 K.BRIKNAROVA,S.TAKAYAMA,L.BRIVE,M.L.HAVERT,D.A.KNEE,J.VELASCO,S.HOMMA,E.CABEZAS,J.STUART,D.W.HOYT,A.C.SATTERTHWAIT,M.LLINAS,J.C.REED,K.R.ELY STRUCTURAL ANALYSIS OF BAG1 COCHAPERONE AND ITS INTERACTIONS WITH HSC70 HEAT SHOCK PROTEIN. 2001 NAT.STRUCT.BIOL. 8 349 nmr 1i6z A 226 355 100 0 1 1i6z 3654 Monomer monomer 1i6zA Q60739 IID50180 2 2lwp NMR 23277101 H.W.HUANG,C.YU THE NMR SOLUTION STRUCTURE OF THE UBIQUITIN HOMOLOGY DOMAIN OF BCL-2-ASSOCIATED ATHANOGENE 1 (BAG-1-UBH) FROM MUS MUSCULUS. 2013 BIOCHEM.BIOPHYS.RES.COMMUN. 431 86 nmr 2lwp A 137 233 100 0 1 2lwp_1 2607 Monomer monomer 2lwpA Q60739 IID50180 3 2m8s NMR 24628338 K.W.HUNG,H.W.HUANG,C.C.CHO,S.C.CHANG,C.YU NUCLEAR MAGNETIC RESONANCE STRUCTURE OF THE CYTOPLASMIC TAIL OF HEPARIN BINDING EGF-LIKE GROWTH FACTOR (PROHB-EGF-CT) COMPLEXED WITH THE UBIQUITIN HOMOLOGY DOMAIN OF BCL-2-ASSOCIATED ATHANOGENE 1 FROM MUS MUSCULUS (MBAG-1-UBH). 2014 BIOCHEMISTRY 53 1935 nmr 2m8s A 137 233 100 0 1 2m8s_1 2649 Hetero dimer 2m8sA Q60739 IID50180 2m8sB Q99075 IID00579 2m8sA-2m8sB 137-355 1-136 2550 PF00240 180->230 5.2e-11 Ubiquitin family hmm pfm 2551 PF02179 266->334 3e-10 BAG domain hmm pfm 4924 1i6zA_ 221->355 1e-51 BAG domain hmm scp 4925 1wggA_ 149->236 6e-15 Ubiquitin-like hmm scp 9768 1wxvA1 154->232 7e-23 rps scp 9769 3ldqB1 232->341 5e-24 rps scp