20210801 20180803 20180425 20210801 IID50220 Nuclear receptor subfamily 0 group B member 2 Orphan nuclear receptor SHP Small heterodimer partner Rattus norvegicus 260 P97947 Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1. Nucleus envelope. SL-0178 unkown 0 0 Symmetric dimethylarginine; by PRMT5 57 57 MSSSQSGVCPCQGSASHPTILYTLLSPGPRTRPMAPASRSHCLCQQHRPVRLCAPHRTCREALDVLGKTVAFLRNLPSFCLLPHEDQRRLLEGCWGPLFLLGLAQDTVTFEVAEAPVPSILKKILLEEPNSGAQGAQPPDPPQPSLAAVQWLQHCLESFWSLELGPKEYAYLKGTILFNPDVPGLHASCHIAHLQQEAHWALCEVLEPWYPASQGRLARILLMASTLKNISCTLLVDLFFRPVIGDVDITELLEDMLLLR 1 1zh7C 16 26 order 3 2 1zh7D 16 26 order 3 3 1zgyB 115 117 disorder 2 4 1zgyB 118 129 order 2 5 1zgyB 130 131 disorder 2 6 1yp0B 17 28 order 1 1 1yp0 X-RAY 293K 6 15721253 Y.LI,M.CHOI,G.CAVEY,J.DAUGHERTY,K.SUINO,A.KOVACH,N.BINGHAM,S.KLIEWER,H.XU 2005 MOL.CELL 17 491 x-ray 1yp0 B 17 28 100 0 1 1yp0_1 3396 Hetero dimer 1yp0A P33242 IID50074 1yp0B P97947 IID50220 1yp0A-1yp0B 2 1zgy X-RAY 293K 7 15976031 Y.LI,M.CHOI,K.SUINO,A.KOVACH,J.DAUGHERTY,S.A.KLIEWER,H.E.XU 2005 PROC.NATL.ACAD.SCI.USA 102 9505 x-ray 1zgy B 115 131 100 2 115 117 130 131 1 1zgy_1 3424 Hetero dimer 1zgyA P37231 IID00041 1zgyB P97947 IID50220 1zgyA-1zgyB 3 1zh7 X-RAY 293K 7 15976031 Y.LI,M.CHOI,K.SUINO,A.KOVACH,J.DAUGHERTY,S.A.KLIEWER,H.E.XU 2005 PROC.NATL.ACAD.SCI.USA 102 9505 x-ray 1zh7 C 16 26 100 0 x-ray 1zh7 D 16 26 100 0 1 1zh7_1 1668 Hetero dimer 1zh7C P97947 IID50220 1zh7A P45448 IID50211 1zh7C-1zh7A 2 1zh7_2 1668 Hetero dimer 1zh7D P97947 IID50220 1zh7B P45448 IID50211 1zh7D-1zh7B 54-260 1-53 2628 PF00104 68->241 1.5e-19 Ligand-binding domain of nuclear hormone receptor hmm pfm 5011 1hg4A_ 18->257 1.8e-51 hmm scp 9845 1pzlA 15->258 7e-34 rps scp